Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1B (muscle) | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 2 | 658 aa | 629 aa | 30.7 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 1B (muscle) | 738 aa | 617 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | aspartyl proteinase, putative | 0.0322 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0406 | 0.1337 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0406 | 0.1337 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0322 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 0.7858 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0322 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0949 | 1 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0406 | 0.1337 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0322 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0322 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0406 | 0.1337 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0322 | 0 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0322 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0814 | 0.7858 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0322 | 0 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0406 | 0.1337 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0322 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0395 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.0542 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 5.4374 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 15.5078 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | = 20.7543 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.