Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.5176 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0269 | 0.5176 | 1 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0269 | 0.5176 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0269 | 0.5176 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.5176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0049 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1338 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 0.2242 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 55.9882 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.