TDR Targets

Basic information

Technical information

TDR Targets ID: 1923430
Name: N-(9-methylpurin-6-yl)benzamide
MW: 253.259 | Formula: C13H11N5O
H donors: 1 H acceptors: 4 LogP: 1.22 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)Nc1ncnc2c1ncn2C
InChi: 1S/C13H11N5O/c1-18-8-16-10-11(14-7-15-12(10)18)17-13(19)9-5-3-2-4-6-9/h2-8H,1H3,(H,14,15,17,19)
InChiKey: QIAGWBDCSUYAHR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(9-methyl-6-purinyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin B precursor	0.0317	0.008	0.0062
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0754	0.0218	0.0213
Loa Loa (eye worm)	hypothetical protein	0.057	0.016	0.733
Echinococcus granulosus	cathepsin L cysteine proteinase	0.057	0.016	0.7293
Brugia malayi	cathepsin L-like cysteine proteinase	0.0121	0.0018	0.0719
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0121	0.0018	0.0013
Trypanosoma cruzi	cysteine peptidase, putative	0.057	0.016	0.7083
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0038	0.1725
Echinococcus multilocularis	cathepsin b	0.0754	0.0218	1
Brugia malayi	Cathepsin L-like precursor	0.0182	0.0038	0.1609
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0303	0.0076	0.2872
Brugia malayi	Papain family cysteine protease containing protein	0.057	0.016	0.7293
Plasmodium vivax	unspecified product	0.0182	0.0038	0.0019
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.057	0.016	0.0141
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0182	0.0038	0.1609
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.057	0.016	0.733
Brugia malayi	Papain family cysteine protease containing protein	0.0121	0.0018	0.0719
Entamoeba histolytica	cysteine proteinase 1, putative	0.0303	0.0076	0.4054
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0072	0.0003	0.0138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0388	0.0102	0.0162
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0317	0.008	0.0127
Entamoeba histolytica	cysteine proteinase, putative	0.0388	0.0102	0.5946
Brugia malayi	Cathepsin L-like precursor	0.057	0.016	0.7293
Trypanosoma cruzi	cysteine peptidase, putative	0.057	0.016	0.7083
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0121	0.0018	0.0013
Onchocerca volvulus		0.057	0.016	1
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0018	0.0027
Schistosoma mansoni	cathepsin s	0.0182	0.0038	0.0032
Plasmodium vivax	vivapain-2	0.057	0.016	0.0141
Onchocerca volvulus	Cathepsin L homolog	0.057	0.016	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.057	0.016	0.733
Loa Loa (eye worm)	fibroinase	0.057	0.016	0.733
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	3.1833	1	1
Onchocerca volvulus	Cathepsin F homolog	0.057	0.016	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0388	0.0102	0.4628
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0754	0.0218	0.0213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Plasmodium falciparum	dipeptidyl aminopeptidase 3	1.2154	0.3806	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0102	0.4702
Onchocerca volvulus		0.057	0.016	1
Leishmania major	cathepsin L-like protease	0.057	0.016	1
Onchocerca volvulus		0.057	0.016	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0102	0.4702
Giardia lamblia	Dipeptidyl-peptidase I precursor	1.2154	0.3806	0.3794
Echinococcus granulosus	cathepsin L	0.0303	0.0076	0.3384
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0018	0.0027
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Plasmodium vivax	vivapain-3	0.0303	0.0076	0.0057
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0303	0.0076	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0018	0.0846
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0121	0.0018	0.0013
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	3.1833	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0121	0.0018	0.0719
Onchocerca volvulus		0.0388	0.0102	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0018	0.0846
Onchocerca volvulus		0.057	0.016	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Loa Loa (eye worm)	ctsf protein	0.057	0.016	0.733
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0018	0.0846
Leishmania major	cathepsin L-like protease	0.057	0.016	1
Plasmodium vivax	vivapain-1	0.0303	0.0076	0.0057
Schistosoma mansoni	cathepsin F (C01 family)	0.057	0.016	0.0155
Echinococcus granulosus	cathepsin l cysteine peptidase	0.057	0.016	0.7293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Giardia lamblia	Dipeptidyl-peptidase I precursor	1.2154	0.3806	0.3794
Trypanosoma cruzi	cruzipain precursor, putative	0.057	0.016	0.7083
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Brugia malayi	Papain family cysteine protease containing protein	0.0303	0.0076	0.3384
Brugia malayi	Cathepsin L-like precursor	0.0388	0.0102	0.4628
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Trypanosoma cruzi	cysteine proteinase, putative	0.0303	0.0076	0.2872
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.057	0.016	0.0141
Echinococcus granulosus	cathepsin L cysteine protease	0.0303	0.0076	0.3384
Schistosoma mansoni	cathepsin F (C01 family)	0.0388	0.0102	0.0097
Brugia malayi	fibroinase precursor	0.0121	0.0018	0.0719
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.057	0.016	0.7293
Echinococcus multilocularis	cathepsin L	0.0121	0.0018	0.0719
Echinococcus multilocularis	cysteine protease	0.057	0.016	0.7293
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0018	0.0846
Onchocerca volvulus		0.057	0.016	1
Entamoeba histolytica	cysteine proteinase, putative	0.0303	0.0076	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.057	0.016	0.0141
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	3.1833	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0121	0.0018	0.0846
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0121	0.0018	0.0013
Brugia malayi	Papain family cysteine protease containing protein	0.0121	0.0018	0.0719
Entamoeba histolytica	cysteine proteinase, putative	0.0303	0.0076	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0018	0.0846
Echinococcus multilocularis	cysteine protease	0.057	0.016	0.7293
Brugia malayi	Cathepsin L-like precursor	0.057	0.016	0.7293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Brugia malayi	Papain family cysteine protease containing protein	0.0121	0.0018	0.0719
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	3.1833	1	1
Toxoplasma gondii	cathepsin CPC2	1.2154	0.3806	0.3756
Schistosoma mansoni	cathepsin F (C01 family)	0.057	0.016	0.0155
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0303	0.0076	0.0071
Entamoeba histolytica	cysteine proteinase, putative	0.057	0.016	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0018	0.0027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0018	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0121	0.0018	0.0027
Entamoeba histolytica	cysteine proteinase 2	0.0303	0.0076	0.4054
Loa Loa (eye worm)	cathepsin B	0.0317	0.008	0.3677
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0018	0.0027
Echinococcus multilocularis	cathepsin L cysteine protease	0.057	0.016	0.7293
Echinococcus multilocularis	cathepsin b	0.0754	0.0218	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0018	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0018	0.0027
Schistosoma mansoni	cathepsin S (C01 family)	0.0121	0.0018	0.0013
Trypanosoma cruzi	cysteine peptidase, putative	0.057	0.016	0.7083
Loa Loa (eye worm)	hypothetical protein	0.0754	0.0218	1
Brugia malayi	Cathepsin L-like precursor	0.057	0.016	0.7293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0121	0.0018	0.0027
Leishmania major	cathepsin L-like protease	0.057	0.016	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0754	0.0218	0.0213
Schistosoma mansoni	cathepsin C	0.0121	0.0018	0.0013
Brugia malayi	Cathepsin L-like precursor	0.057	0.016	0.7293
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0388	0.0102	0.4212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0317	0.008	0.0525
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0121	0.0018	0.0846
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0303	0.0076	0.0071
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	1.98	0.6213	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0182	0.0038	0.0959
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0121	0.0018	0.0027
Toxoplasma gondii	cathepsin CPC1	3.1833	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0121	0.0018	0.0013
Plasmodium falciparum	dipeptidyl aminopeptidase 2	3.1833	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0121	0.0018	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0038	0.1725
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	1.2154	0.3806	0.3794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0388	0.0102	0.0162
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0121	0.0018	0.0027
Brugia malayi	Cathepsin L-like precursor	0.0388	0.0102	0.4628
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0317	0.008	0.3093
Brugia malayi	cathepsin L-like precursor	0.0388	0.0102	0.4628
Onchocerca volvulus	Cathepsin L homolog	0.057	0.016	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0121	0.0018	0.0013
Entamoeba histolytica	cysteine proteinase, putative	0.0303	0.0076	0.4054
Toxoplasma gondii	preprocathepsin c precursor, putative	3.1833	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.057	0.016	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0121	0.0018	0.0846
Echinococcus multilocularis	cathepsin L	0.0303	0.0076	0.3384
Brugia malayi	Cathepsin L-like precursor	0.057	0.016	0.7293
Giardia lamblia	Cathepsin B precursor	0.0317	0.008	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0121	0.0018	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0018	0.0846
Echinococcus granulosus	cysteine protease	0.0303	0.0076	0.3384
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.057	0.016	0.0255
Echinococcus granulosus	cathepsin b	0.0754	0.0218	1
Echinococcus granulosus	cathepsin l1	0.0388	0.0102	0.4628
Loa Loa (eye worm)	cysteine protease	0.057	0.016	0.733
Trypanosoma cruzi	cysteine peptidase, putative	0.057	0.016	0.7083
Toxoplasma gondii	cathepsin CPL	0.057	0.016	0.008
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0754	0.0218	1
Giardia lamblia	Encystation-specific protease	1.2154	0.3806	0.3794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Onchocerca volvulus		0.057	0.016	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0303	0.0076	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.057	0.016	0.0255
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0121	0.0018	0.0719
Echinococcus multilocularis	cathepsin L cysteine protease	0.057	0.016	0.7293
Trypanosoma cruzi	cysteine proteinase, putative	0.0303	0.0076	0.2872
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0018	0.0027
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Giardia lamblia	Cathepsin B precursor	0.0317	0.008	0.0062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Trypanosoma cruzi	cysteine protease, putative	0.0303	0.0076	0.2872
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0754	0.0218	1
Brugia malayi	Cathepsin L-like precursor	0.057	0.016	0.7293
Onchocerca volvulus		0.057	0.016	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0038	0.1725
Echinococcus granulosus	cathepsin l1	0.057	0.016	0.7293
Plasmodium vivax	unspecified product	0.0303	0.0076	0.0057
Echinococcus granulosus	cathepsin L	0.0121	0.0018	0.0719
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0121	0.0018	0.0719
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0121	0.0018	0.0719
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0182	0.0038	0.1609
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0121	0.0018	0.0013
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0121	0.0018	0.0013
Trypanosoma cruzi	cysteine peptidase, putative	0.0182	0.0038	0.0959
Leishmania major	cysteine peptidase A (CPA)	0.057	0.016	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0102	0.4702
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0121	0.0018	0.0013
Trypanosoma cruzi	cysteine peptidase, putative	0.0303	0.0076	0.2872
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0754	0.0218	0.0213
Entamoeba histolytica	cysteine proteinase, putative	0.0303	0.0076	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0018	0.0027
Leishmania major	cathepsin L-like protease	0.057	0.016	1
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.057	0.016	1
Brugia malayi	cathepsin L precursor	0.0121	0.0018	0.0719
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0182	0.0038	0.1725
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0018	0.0027
Echinococcus granulosus	cathepsin b	0.0754	0.0218	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0303	0.0076	0.0071
Entamoeba histolytica	cysteine protease, putative	0.0303	0.0076	0.4054
Entamoeba histolytica	cysteine protease, putative	0.057	0.016	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0317	0.008	0.0075
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.057	0.016	0.7293
Brugia malayi	Papain family cysteine protease containing protein	0.0303	0.0076	0.3384
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0121	0.0018	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0018	0.0027
Leishmania major	cathepsin L-like protease	0.057	0.016	1
Leishmania major	cathepsin L-like protease	0.057	0.016	1
Plasmodium vivax	vivapain-2	0.057	0.016	0.0141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.057	0.016	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0303	0.0076	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.057	0.016	0.0255
Leishmania major	cathepsin L-like protease	0.057	0.016	1
Leishmania major	cathepsin L-like protease	0.057	0.016	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 3.7 %	Inhibition of BRD4 bromodomain-1 (unknown origin) at 100 uM by europium based LANCE TR-FRET assay	ChEMBL.	25678016
Inhibition (binding)	< 50 %	Inhibition of BRD4 bromodomain-1 (unknown origin) at 300 uM by europium based LANCE TR-FRET assay	ChEMBL.	25678016

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3398342

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1923430