Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 2 | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1B (muscle) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 1B (muscle) | 738 aa | 617 aa | 28.0 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 2 | 658 aa | 629 aa | 30.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0405 | 0.2734 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0405 | 0.2734 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0406 | 0.2736 | 0.5 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0405 | 0.2734 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0406 | 0.2736 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0406 | 0.2736 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0406 | 0.2736 | 0.5 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0405 | 0.2734 | 0.5 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0406 | 0.2736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 1 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0405 | 0.2734 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0252 | 0 | 0.5 |
Toxoplasma gondii | cathepsin CPC1 | 0.0405 | 0.2734 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0405 | 0.2734 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0405 | 0.2734 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1881 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.2237 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 2.9705 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | = 13.8263 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.