TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.418 | Formula: C19H23N5O3
H donors: 2 H acceptors: 5 LogP: 0.29 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CN(C2CCOCC2)c2c(N1)ncc(n2)c1ccc(nc1)C(O)(C)C
InChi: 1S/C19H23N5O3/c1-19(2,26)15-4-3-12(9-20-15)14-10-21-17-18(22-14)24(11-16(25)23-17)13-5-7-27-8-6-13/h3-4,9-10,13,26H,5-8,11H2,1-2H3,(H,21,23,25)
InChiKey: IBHHJGZOOHWZKC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0052	0.0926	0.0346
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.112	0.0552
Giardia lamblia	GTOR	0.0058	0.112	0.9047
Schistosoma mansoni	gliotactin	0.0052	0.0926	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0728	0.1562
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.3378	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0047	0.0729	0.6514
Brugia malayi	Carboxylesterase family protein	0.0052	0.0926	0.0346
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.3378	0.2955
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0043	0.0601	0.5364
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.2071	0.5839
Loa Loa (eye worm)	hypothetical protein	0.0309	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0056	0.1055	0.1637
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0629	0.1248
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0629	0.1248
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.2757	0.2294
Echinococcus multilocularis	carboxylesterase 5A	0.0309	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0058	0.112	0.2533
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.3378	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0629	0.1248
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0029	0.011	0.0985
Onchocerca volvulus		0.0052	0.0926	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.0926	0.0346
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0058	0.112	0.0213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0489	0.0803
Loa Loa (eye worm)	hypothetical protein	0.008	0.1907	0.1611
Brugia malayi	Carboxylesterase family protein	0.0052	0.0926	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0239	0.0005
Schistosoma mansoni	BC026374 protein (S09 family)	0.0052	0.0926	0.0346
Loa Loa (eye worm)	acetylcholinesterase 1	0.0309	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0926	0.0594
Loa Loa (eye worm)	carboxylesterase	0.0052	0.0926	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0309	1	1
Brugia malayi	Carboxylesterase family protein	0.0309	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.2071	0.5839
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.6201	0.6062
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0448	0.0671
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0058	0.112	0.0552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0349	0.0356
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0226	0.7053	0.6865
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0043	0.0601	0.1157
Echinococcus granulosus	carboxylesterase 5A	0.0309	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0043	0.0601	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0926	0.0594
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.112	0.281
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0728	0.1562
Trypanosoma cruzi	target of rapamycin kinase 3	0.0047	0.0729	0.1243
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.112	0.281
Echinococcus multilocularis	acetylcholinesterase	0.0309	1	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0058	0.112	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0058	0.112	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.0926	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0551	0.0205
Loa Loa (eye worm)	carboxylesterase	0.0309	1	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0058	0.112	0.1869
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.3131	0.911
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0728	0.1562
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.1907	0.1082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0728	0.1562
Trichomonas vaginalis	spcc417.12 protein, putative	0.0052	0.0926	0.2194
Loa Loa (eye worm)	carboxylesterase	0.0052	0.0926	0.0594
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0052	0.0926	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0239	0.0005
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.1907	0.139
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0349	0.0356
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0239	0.0005
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.0926	0.0346
Onchocerca volvulus		0.0052	0.0926	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0629	0.1248
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0058	0.112	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0052	0.0926	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0629	0.1248
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0629	0.1248
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0226	0.7053	0.6753
Entamoeba histolytica	hypothetical protein	0.0098	0.2525	0.6931
Brugia malayi	Carboxylesterase family protein	0.0052	0.0926	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0926	0.0594
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.1907	0.1082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0349	0.0356
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.1218	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0926	0.0594
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0728	0.1562
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0044	0.0629	0.5
Echinococcus granulosus	acetylcholinesterase	0.0309	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0043	0.0601	0.1157
Brugia malayi	Carboxylesterase family protein	0.0052	0.0926	0.0346
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0309	1	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0052	0.0926	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0338	0.032
Onchocerca volvulus		0.0052	0.0926	0.5
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0058	0.112	0.1869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0629	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0926	0.0594
Onchocerca volvulus		0.0052	0.0926	0.5
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0226	0.7053	0.6753
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0926	0.0594
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0058	0.112	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.3378	1
Onchocerca volvulus		0.0052	0.0926	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0058	0.112	0.2533
Echinococcus granulosus	acetylcholinesterase	0.0309	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.3378	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0043	0.0601	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0926	0.0594
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0239	0.0005
Schistosoma mansoni	acetylcholinesterase	0.0052	0.0926	0.0346
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.2525	0.6931
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.3378	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0058	0.112	0.0213
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.3378	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.112	0.281
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.084	0.1918
Mycobacterium ulcerans	carboxylesterase, LipT	0.0052	0.0926	0.5
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0052	0.0926	0.5
Echinococcus multilocularis	acetylcholinesterase	0.0309	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0058	0.112	0.0794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0338	0.032
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0052	0.0926	0.2194

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.185 uM	Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assay	ChEMBL.	26083478
IC50 (binding)	= 4.7 uM	Inhibition of PI3K-alpha (unknown origin) by mobility shift assay	ChEMBL.	26083478

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3586392

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1936779