Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | complement factor D (adipsin) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | complement factor D (adipsin) | 253 aa | 280 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2638 | 1 |
Trichomonas vaginalis | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium leprae | Probable guanylate kinase Gmk (GMP kinase). | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | MAGUK homolog | 0.0043 | 0.0338 | 0.0338 |
Leishmania major | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | membrane associated guanylate kinase, WW and PDZ | 0.0091 | 0.2539 | 0.6065 |
Trichomonas vaginalis | sap-102, putative | 0.0036 | 0 | 0.5 |
Plasmodium vivax | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | membrane associated guanylate kinase, WW and PDZ | 0.0091 | 0.2539 | 0.6065 |
Echinococcus multilocularis | MAGUK p55 subfamily | 0.0043 | 0.0338 | 0.0807 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0053 | 0.0805 | 0.3051 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0053 | 0.0805 | 0.3051 |
Brugia malayi | Guanylate kinase family protein | 0.0043 | 0.0338 | 0.1281 |
Trichomonas vaginalis | discs large, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | ATP-dependent RNA Helicase | 0.0043 | 0.0338 | 0.0338 |
Brugia malayi | ShTK domain containing protein | 0.0053 | 0.0805 | 0.3051 |
Schistosoma mansoni | maguk P55 subfamily member 35 | 0.0043 | 0.0338 | 0.0338 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0053 | 0.0805 | 0.3051 |
Onchocerca volvulus | 0.0053 | 0.0805 | 1 | |
Trypanosoma cruzi | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | peripheral plasma membrane protein CASK | 0.0043 | 0.0338 | 0.0807 |
Schistosoma mansoni | tyrosinase precursor | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | peripheral plasma membrane protein CASK | 0.0043 | 0.0338 | 0.1281 |
Trypanosoma brucei | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | MAGUK homolog | 0.0043 | 0.0338 | 0.0338 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0053 | 0.0805 | 0.3051 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0053 | 0.0805 | 0.3051 |
Mycobacterium ulcerans | guanylate kinase | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | MAGUK p55 subfamily | 0.0043 | 0.0338 | 0.0807 |
Echinococcus multilocularis | 55 kDa erythrocyte membrane protein | 0.0043 | 0.0338 | 0.0807 |
Plasmodium falciparum | guanylate kinase | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | membrane associated guanylate kinase inverted related | 0.0091 | 0.2539 | 0.2539 |
Chlamydia trachomatis | guanylate kinase | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | membrane associated guanylate kinase ww and pdz | 0.0127 | 0.4186 | 1 |
Mycobacterium tuberculosis | Probable guanylate kinase Gmk | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2539 | 0.9625 |
Echinococcus multilocularis | 0.0127 | 0.4186 | 1 | |
Wolbachia endosymbiont of Brugia malayi | guanylate kinase | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0805 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0338 | 0.1281 |
Echinococcus multilocularis | membrane associated guanylate kinase ww and pdz | 0.0091 | 0.2539 | 0.6065 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0805 | 0.3051 |
Echinococcus granulosus | disks large 3 | 0.0043 | 0.0338 | 0.0807 |
Entamoeba histolytica | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | 55 kDa erythrocyte membrane protein | 0.0043 | 0.0338 | 0.0807 |
Brugia malayi | Peripheral plasma membrane protein CASK | 0.0043 | 0.0338 | 0.1281 |
Brugia malayi | PDZ domain containing protein | 0.0093 | 0.2638 | 1 |
Echinococcus multilocularis | disks large 3 | 0.0043 | 0.0338 | 0.0807 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0053 | 0.0805 | 0.3051 |
Echinococcus multilocularis | peripheral plasma membrane protein CASK | 0.0043 | 0.0338 | 0.0807 |
Schistosoma mansoni | membrane associated guanylate kinase inverted related | 0.0127 | 0.4186 | 0.4186 |
Schistosoma mansoni | maguk P55 subfamily member 26 | 0.0043 | 0.0338 | 0.0338 |
Toxoplasma gondii | guanylate kinase family protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | guanylate kinase, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | guanylate kinase | 0.0043 | 0.0338 | 0.1281 |
Echinococcus granulosus | MAGUK p55 subfamily | 0.0043 | 0.0338 | 0.0807 |
Onchocerca volvulus | 0.0053 | 0.0805 | 1 | |
Schistosoma mansoni | cell polarity protein | 0.0043 | 0.0338 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0805 | 0.3051 |
Onchocerca volvulus | 0.0053 | 0.0805 | 1 | |
Echinococcus granulosus | membrane associated guanylate kinase ww and pdz | 0.0091 | 0.2539 | 0.6065 |
Echinococcus granulosus | MAGUK p55 subfamily | 0.0043 | 0.0338 | 0.0807 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0053 | 0.0805 | 0.3051 |
Brugia malayi | Guanylate kinase family protein | 0.0043 | 0.0338 | 0.1281 |
Echinococcus granulosus | 3'partial|membrane associated guanylate kinase ww and pdz | 0.0091 | 0.2539 | 0.6065 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0053 | 0.0805 | 0.3051 |
Echinococcus granulosus | MAGUK p55 subfamily | 0.0043 | 0.0338 | 0.0807 |
Leishmania major | guanylate kinase-like protein | 0.0036 | 0 | 0.5 |
Giardia lamblia | Guanylate kinase | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | MAGUK p55 subfamily | 0.0043 | 0.0338 | 0.0807 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 nM | BindingDB_Patents: In Vitro Assay. Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at various concentrations for 1 hour at room temperature in 0.1 M Hepes buffer, pH 7.5, containing 1 mM MgCl2, 1 M NaCl and 0.05% CHAPS. A synthetic substrate Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine are added to final concentrations of 200 µM and 25 µM, respectively. The increase in fluorescence is recorded at excitation of 485 nm and emission at 535 nm in a microplate spectrofluorimeter. IC50 values are calculated from percentage of inhibition of complement factor D-activity as a function of test compound concentration. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.