Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1384 | 0.0846 | 0.5531 |
Echinococcus multilocularis | peroxidasin | 0.0701 | 0.0307 | 0.0168 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0541 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.1384 | 0.0846 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.3633 | 0.2622 | 0.2622 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.062 | 0.0242 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0927 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.1384 | 0.0846 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.7713 | 0.5845 | 0.5845 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.3633 | 0.2622 | 1 |
Schistosoma mansoni | pyruvate carboxylase | 0.1384 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.3506 | 0.2522 | 0.2285 |
Schistosoma mansoni | peroxidasin | 0.0701 | 0.0307 | 0.0307 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.1384 | 0.0846 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.0492 | 0.0142 | 0.1676 |
Chlamydia trachomatis | biotin carboxylase | 0.1257 | 0.0745 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.1384 | 0.0846 | 0.3226 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1384 | 0.0846 | 0.3226 |
Onchocerca volvulus | 1.2973 | 1 | 1 | |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.1384 | 0.0846 | 1 |
Trypanosoma brucei | unspecified product | 0.091 | 0.0471 | 0.1798 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0492 | 0.0142 | 0.0927 |
Toxoplasma gondii | pyruvate carboxylase | 0.1384 | 0.0846 | 0.3226 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.3633 | 0.2622 | 0.2516 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.062 | 0.0242 | 0.5 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.1384 | 0.0846 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.3633 | 0.2622 | 0.2516 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0492 | 0.0142 | 0.1676 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 1.2973 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0541 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.3633 | 0.2622 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0492 | 0.0142 | 0.0142 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.1384 | 0.0846 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1384 | 0.0846 | 0.3226 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.1384 | 0.0846 | 0.0714 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.3633 | 0.2622 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.1384 | 0.0846 | 1 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0492 | 0.0142 | 0.1676 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.1384 | 0.0846 | 0.0714 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1384 | 0.0846 | 0.5531 |
Loa Loa (eye worm) | hypothetical protein | 1.2973 | 1 | 1 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.0492 | 0.0142 | 0.0541 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2629 | 0.1829 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1384 | 0.0846 | 0.0846 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.1384 | 0.0846 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2629 | 0.1829 | 1 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0492 | 0.0142 | 0.0541 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1384 | 0.0846 | 0.0846 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0492 | 0.0142 | 0.1676 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.3506 | 0.2522 | 0.2285 |
Echinococcus granulosus | peroxidasin | 0.0701 | 0.0307 | 0.0168 |
Schistosoma mansoni | peroxidasin | 0.0701 | 0.0307 | 0.0307 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.2249 | 0.1529 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.5261 | 0.3908 | 0.3908 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.3633 | 0.2622 | 1 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0492 | 0.0142 | 0.1676 |
Leishmania major | carboxylase, putative | 0.1384 | 0.0846 | 0.3226 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0492 | 0.0142 | 0.1676 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0927 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0492 | 0.0142 | 0.1676 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 400000 nM | BindingDB_Patents: Inhibition Assay. The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay (Greenlee et al., J Pharmacol Exp Ther, 1978). Our first studies were with highly purified human CYP2A6 that provided a convenient and relatively high-throughput measure of CYP2A6 inhibition. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.