TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 351.445 | Formula: C20H25N5O
H donors: 2 H acceptors: 4 LogP: 2.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OCCC1CCN(CC1)c1ncnc(c1C#Cc1ccc(nc1)N)CC
InChi: 1S/C20H25N5O/c1-2-18-17(5-3-16-4-6-19(21)22-13-16)20(24-14-23-18)25-10-7-15(8-11-25)9-12-26/h4,6,13-15,26H,2,7-12H2,1H3,(H2,21,22)
InChiKey: YYUGXMIVWRYUSI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0289	0.0272
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0047	0.1357	0.7154
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0289	0.0719
Loa Loa (eye worm)	hypothetical protein	0.01	0.3628	0.4545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1356	0.297
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.7982	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.2784	0.2834
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0289	0.0129
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0047	0.1357	0.7154
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0043	0.1202	0.2633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1356	0.297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0897	0.1965
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0058	0.183	0.3778
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0289	0.0121
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1356	0.297
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0902	0.1668
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.3532	0.7652
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1142	0.1431
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0029	0.0608	0.264
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0058	0.183	0.3778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0289	0.0633
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.01	0.3628	0.7869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0897	0.1965
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0289	0.0719
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.195	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.4564	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0058	0.183	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.1236	0.2708
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0289	0.0633
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0226	0.9014	0.9587
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0058	0.183	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.183	0.3778
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0026	0.0474	0.1836
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0763	0.1672
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0763	0.1672
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.2784	0.2834
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0058	0.183	1
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.0235	0.9395	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0289	0.0272
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0902	0.113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.183	0.4009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.1236	0.2708
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0043	0.1202	0.2633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0761	0.1668
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0058	0.183	0.3778
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0043	0.1202	0.2633
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.0235	0.9395	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.4564	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1356	0.297
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0226	0.9014	0.9587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.1236	0.2708
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0019	0.017	0.0372
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.3812	0.8289
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0058	0.183	0.18
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.4265	0.9319
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0289	0.0633
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.4564	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0019	0.017	0.0372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1356	0.297
Loa Loa (eye worm)	hypothetical protein	0.008	0.2784	0.3488
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.4564	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0289	0.0129
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0289	0.0719
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0883	0.1935
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.183	0.4009
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0043	0.1202	0.2348
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0019	0.017	0.1372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.1236	0.2708
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0058	0.183	0.1689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0897	0.1965
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0289	0.0633
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.4564	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0289	0.0362
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0763	0.1672
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0019	0.017	0.5
Giardia lamblia	GTOR	0.0058	0.183	0.9047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0761	0.1668
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0133	0.0292
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0019	0.017	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0289	0.0719
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.1236	0.2708
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1016	0.2227
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0058	0.183	0.18
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.1067	0.2337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0289	0.0633
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.4564	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.1491	0.3267
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.2982	0.6533
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0043	0.1202	0.6215
Onchocerca volvulus		0.01	0.3628	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0056	0.1752	0.3601
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0019	0.017	0.0212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.1202	0.2348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0761	0.1668
Trypanosoma cruzi	target of rapamycin kinase 3	0.0047	0.1357	0.2703
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.1202	0.2348
Loa Loa (eye worm)	phosphatidylinositol 3	0.0058	0.183	0.2292
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0883	0.1935
Entamoeba histolytica	hypothetical protein	0.0098	0.3532	0.7652
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.2982	0.6533
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.183	0.4009
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.2784	0.5949
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.1236	0.2708
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0058	0.183	0.3778
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0019	0.017	0.0372
Schistosoma mansoni	hypothetical protein	0.0249	1	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0019	0.017	0.1372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0763	0.1672
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0226	0.9014	0.8997
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0044	0.1236	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0043	0.1202	0.105
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0289	0.0272
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0058	0.183	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.1236	0.2708
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0043	0.1202	0.2348
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.4564	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5 nM	BindingDB_Patents: Kinase Activity Assay. The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Fluorescent Protein) and paired with a corresponding Tb-labeled phospho-specific antibody. The assay itself is divided into two phases: the reaction phase and the detection phase. In the reaction phase, all components required for the kinase reaction are added to the well, including the labeled protein substrate. The reaction is allowed to incubate for 60 minutes. After the reaction, EDTA is added to stop the kinase reaction, and terbium-labeled antibody is added to bind phosphorylated product. Because the terbium chelate is stable at the EDTA concentrations used to stop a kinase assay, the antibody and EDTA can be pre-mixed prior to addition to minimize pipetting steps. Binding of the terbium labeled antibody to the fluorophore-labeled phosphorylated product brings the terbium and GFP into proximity, resulting in an increase in TR-FRET.	ChEMBL.	No reference
IC50 (binding)	= 35 nM	Filter-Binding-Assay	BINDINGDB.	No reference
IC50 (binding)	= 35 nM	Filter-Binding-Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3670157

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1967982