Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peripheral plasma membrane protein CASK | 0.0074 | 0.0424 | 0.0424 |
Schistosoma mansoni | maguk P55 subfamily member 35 | 0.0074 | 0.0424 | 0.0807 |
Mycobacterium tuberculosis | Probable guanylate kinase Gmk | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | membrane associated guanylate kinase ww and pdz | 0.0157 | 0.3183 | 0.3183 |
Loa Loa (eye worm) | guanylate kinase | 0.0074 | 0.0424 | 0.1281 |
Wolbachia endosymbiont of Brugia malayi | guanylate kinase | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | MAGUK homolog | 0.0074 | 0.0424 | 0.0807 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.3307 | 1 |
Mycobacterium leprae | Probable guanylate kinase Gmk (GMP kinase). | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | MAGUK p55 subfamily | 0.0074 | 0.0424 | 0.0424 |
Echinococcus multilocularis | MAGUK p55 subfamily | 0.0074 | 0.0424 | 0.0424 |
Echinococcus multilocularis | MAGUK p55 subfamily | 0.0074 | 0.0424 | 0.0424 |
Trypanosoma cruzi | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | peripheral plasma membrane protein CASK | 0.0074 | 0.0424 | 0.1281 |
Echinococcus granulosus | MAGUK p55 subfamily | 0.0074 | 0.0424 | 0.0424 |
Chlamydia trachomatis | guanylate kinase | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | 0.0218 | 0.5248 | 0.5248 | |
Leishmania major | guanylate kinase-like protein | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.036 | 1 | 1 |
Schistosoma mansoni | ATP-dependent RNA Helicase | 0.0074 | 0.0424 | 0.0807 |
Brugia malayi | Peripheral plasma membrane protein CASK | 0.0074 | 0.0424 | 0.1281 |
Toxoplasma gondii | guanylate kinase family protein | 0.0062 | 0 | 0.5 |
Brugia malayi | PDZ domain containing protein | 0.016 | 0.3307 | 1 |
Echinococcus granulosus | membrane associated guanylate kinase ww and pdz | 0.0218 | 0.5248 | 0.5248 |
Schistosoma mansoni | membrane associated guanylate kinase inverted related | 0.0218 | 0.5248 | 1 |
Plasmodium falciparum | guanylate kinase | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | membrane associated guanylate kinase inverted related | 0.0157 | 0.3183 | 0.6065 |
Brugia malayi | Guanylate kinase family protein | 0.0074 | 0.0424 | 0.1281 |
Trypanosoma brucei | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Mycobacterium ulcerans | guanylate kinase | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | disks large 3 | 0.0074 | 0.0424 | 0.0424 |
Echinococcus granulosus | 55 kDa erythrocyte membrane protein | 0.0074 | 0.0424 | 0.0424 |
Echinococcus granulosus | membrane associated guanylate kinase ww and pdz | 0.0157 | 0.3183 | 0.3183 |
Trichomonas vaginalis | sap-102, putative | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | 3'partial|membrane associated guanylate kinase ww and pdz | 0.0157 | 0.3183 | 0.3183 |
Trichomonas vaginalis | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | MAGUK p55 subfamily | 0.0074 | 0.0424 | 0.0424 |
Echinococcus granulosus | peripheral plasma membrane protein CASK | 0.0074 | 0.0424 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.3183 | 0.9625 |
Onchocerca volvulus | 0.0074 | 0.0424 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0424 | 0.1281 |
Schistosoma mansoni | maguk P55 subfamily member 26 | 0.0074 | 0.0424 | 0.0807 |
Trichomonas vaginalis | discs large, putative | 0.0062 | 0 | 0.5 |
Giardia lamblia | Guanylate kinase | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | cell polarity protein | 0.0074 | 0.0424 | 0.0807 |
Entamoeba histolytica | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | membrane associated guanylate kinase, WW and PDZ | 0.0157 | 0.3183 | 0.3183 |
Schistosoma mansoni | MAGUK homolog | 0.0074 | 0.0424 | 0.0807 |
Trichomonas vaginalis | calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Brugia malayi | Guanylate kinase family protein | 0.0074 | 0.0424 | 0.1281 |
Leishmania major | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | 55 kDa erythrocyte membrane protein | 0.0074 | 0.0424 | 0.0424 |
Plasmodium vivax | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | disks large 3 | 0.0074 | 0.0424 | 0.0424 |
Trypanosoma brucei | guanylate kinase, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | MAGUK p55 subfamily | 0.0074 | 0.0424 | 0.0424 |
Echinococcus granulosus | membrane associated guanylate kinase, WW and PDZ | 0.0157 | 0.3183 | 0.3183 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 nM | BindingDB_Patents: Competitive Binding Assay. hNK3 receptor binding experiment were performed using [3H]SR142801 (Catalog No. TRK1035, specific activity: 74.0 Ci/mmol, Amersham, GE Healthcare UK limited, Buckinghamshire, UK) and membrane isolated from HEK293 cells transiently expressing recombinant human NK3 receptor. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.