Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | high affinity choline transporter 1 | 0.0046 | 0.0623 | 0.0623 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1302 | 0.5 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.0623 | 0.0623 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.2753 | 0.3691 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.0362 | 0.0362 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.3909 | 0.3909 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0046 | 0.0623 | 0.4786 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1302 | 0.1746 |
Echinococcus multilocularis | solute carrier family 5 | 0.0181 | 0.7457 | 0.7457 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0362 | 0.0362 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1302 | 0.1302 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.6679 | 0.8956 |
Schistosoma mansoni | inositol transporter | 0.0181 | 0.7457 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1302 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.3909 | 0.3909 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1228 | 0.1228 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0672 | 0.0672 |
Schistosoma mansoni | sodium/solute symporter | 0.0046 | 0.0623 | 0.0836 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0362 | 0.0485 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0181 | 0.7457 | 0.7457 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0673 | 0.0673 |
Echinococcus granulosus | solute carrier family 5 | 0.0181 | 0.7457 | 0.7457 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0181 | 0.7457 | 0.7457 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0181 | 0.7457 | 0.7457 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0362 | 0.0485 |
Brugia malayi | Sodium:solute symporter family protein | 0.0046 | 0.0623 | 0.0623 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1302 | 0.1746 |
Plasmodium falciparum | phd finger protein, putative | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.6679 | 0.6679 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0181 | 0.7457 | 0.7457 |
Echinococcus granulosus | geminin | 0.0166 | 0.6679 | 0.6679 |
Schistosoma mansoni | high-affinity choline transporter | 0.0046 | 0.0623 | 0.0836 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.6679 | 0.8956 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0672 | 0.0901 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.3909 | 0.3909 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0623 | 0.0623 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1302 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0181 | 0.7457 | 0.7457 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.0623 | 0.0623 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0672 | 0.0901 |
Schistosoma mansoni | inositol transporter | 0.0181 | 0.7457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0623 | 0.0623 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1302 | 0.1302 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.183 | 0.183 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0046 | 0.0623 | 0.0623 |
Onchocerca volvulus | 0.0046 | 0.0623 | 0.9273 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1302 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.0362 | 0.0362 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0673 | 0.0673 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1302 | 0.5 |
Brugia malayi | GH02984p | 0.0046 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0.0672 | 1 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1302 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0034 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 460 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using hSGLT2. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.