TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 511.6 | Formula: C23H29N9O3S
H donors: 3 H acceptors: 7 LogP: 0.57 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Cc1nc(N)nc(n1)c1cc(cnc1Nc1ccc(cc1)NC(=O)C)CN1CCN(CC1)S(=O)(=O)C
InChi: 1S/C23H29N9O3S/c1-15-26-22(30-23(24)27-15)20-12-17(14-31-8-10-32(11-9-31)36(3,34)35)13-25-21(20)29-19-6-4-18(5-7-19)28-16(2)33/h4-7,12-13H,8-11,14H2,1-3H3,(H,25,29)(H,28,33)(H2,24,26,27,30)
InChiKey: HSJJSEHEYMTWQC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0226	0.0807	0.0687
Loa Loa (eye worm)	TWK-28 protein	0.0103	0.0309	0.027
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0103	0.0309	0.7576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0027	0.0005
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.0386	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0058	0.0128	0.1869
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0128	0.281
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.0358	0.911
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0103	0.0309	0.7576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.004	0.0356
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0072	0.1248
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0103	0.0309	0.7576
Trypanosoma cruzi	target of rapamycin kinase 3	0.0047	0.0083	0.1243
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0103	0.0309	0.0184
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0043	0.0069	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Mycobacterium ulcerans	transmembrane cation transporter	0.0103	0.0309	0.5
Giardia lamblia	GTOR	0.0058	0.0128	0.372
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0058	0.0128	0.4139
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0051	0.0671
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0027	0.0005
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0103	0.0309	0.7576
Schistosoma mansoni	calcium-activated potassium channel	0.0103	0.0309	0.0242
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0226	0.0807	0.0687
Echinococcus granulosus	calcium activated potassium channel variant	0.0103	0.0309	0.0184
Echinococcus granulosus	potassium channel subfamily K 8	0.0103	0.0309	0.0184
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.0386	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0058	0.0128	0.1869
Onchocerca volvulus		0.0103	0.0309	0.5
Schistosoma mansoni	hypothetical protein	0.2504	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.0128	0.1869
Loa Loa (eye worm)	hypothetical protein	0.0398	0.1501	0.1467
Loa Loa (eye worm)	hypothetical protein	0.2504	1	1
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0103	0.0309	0.7576
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.0218	0.4706
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0056	0.0121	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Toxoplasma gondii	ion channel protein	0.0103	0.0309	1
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0103	0.0309	0.5
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0058	0.0128	0.1976
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Echinococcus multilocularis	small conductance calcium activated potassium	0.2504	1	1
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0103	0.0309	0.0184
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.0309	0.7857
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0103	0.0309	0.7576
Schistosoma mansoni	calcium-activated potassium channel	0.2004	0.7979	0.7965
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.0309	0.7857
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Onchocerca volvulus		0.0103	0.0309	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0043	0.0069	0.2221
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.004	0.0356
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0043	0.0069	0.0817
Echinococcus granulosus	twik family of potassium channels	0.0103	0.0309	0.0184
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0083	0.1562
Schistosoma mansoni	hypothetical protein	0.0103	0.0309	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trypanosoma cruzi	hypothetical protein, conserved	0.0103	0.0309	0.7774
Plasmodium vivax	potassium channel, putative	0.0103	0.0309	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.0309	0.7857
Leishmania major	calcium/potassium channel (CAKC), putative	0.0103	0.0309	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0058	0.0128	0.1976
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0027	0.0005
Plasmodium falciparum	potassium channel	0.0103	0.0309	0.5
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Leishmania major	potassium channel subunit-like protein	0.0103	0.0309	1
Echinococcus multilocularis	potassium channel subfamily K 8	0.0103	0.0309	0.0184
Onchocerca volvulus		0.0103	0.0309	0.5
Onchocerca volvulus		0.0103	0.0309	0.5
Loa Loa (eye worm)	hypothetical protein	0.1056	0.4156	0.4132
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0103	0.0309	0.7774
Leishmania major	ion transport protein-like protein	0.0103	0.0309	1
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0103	0.0309	0.7774
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0072	0.1248
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0058	0.0128	0.4139
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0058	0.0128	0.2533
Schistosoma mansoni	calcium-activated potassium channel	0.2504	1	1
Echinococcus multilocularis	calcium activated potassium channel variant	0.0103	0.0309	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.0315	0.7764
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Echinococcus granulosus	potassium channel subfamily K 8	0.0103	0.0309	0.0184
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.0309	0.7857
Loa Loa (eye worm)	uncoordinated protein 58	0.0103	0.0309	0.027
Onchocerca volvulus		0.0103	0.0309	0.5
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0058	0.0128	0.2533
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.0386	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0218	0.0091
Giardia lamblia	Hypothetical protein	0.0103	0.0309	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0103	0.0309	0.7576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0128	0.281
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.0237	0.5839
Toxoplasma gondii	ion channel protein	0.0103	0.0309	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.0309	0.7857
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0063	0.0023
Trypanosoma cruzi	ion transport protein, putative	0.0103	0.0309	0.7774
Trypanosoma cruzi	ion transport protein, putative	0.0103	0.0309	0.7774
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0218	0.0091
Onchocerca volvulus		0.0103	0.0309	0.5
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Echinococcus multilocularis	twik family of potassium channels	0.0103	0.0309	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0039	0.032
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0103	0.0309	0.7576
Loa Loa (eye worm)	hypothetical protein	0.0948	0.3719	0.3693
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.0386	1
Echinococcus granulosus	potassium channel subfamily K	0.0103	0.0309	0.0184
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0027	0.0005
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0103	0.0309	0.0184
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0072	0.1248
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0103	0.0309	0.7774
Mycobacterium ulcerans	ion transport protein	0.0103	0.0309	0.5
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0103	0.0309	0.7576
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.0386	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0029	0.0013	0.0408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0096	0.1918
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0056	0.0803
Brugia malayi	hypothetical protein	0.0103	0.0309	0.7576
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.0289	0.6931
Echinococcus multilocularis	twik family of potassium channels	0.0103	0.0309	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0083	0.1562
Brugia malayi	hypothetical protein	0.0103	0.0309	0.7576
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0103	0.0309	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0103	0.0309	0.027
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0103	0.0309	0.7576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0072	0.1248
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0103	0.0309	0.7576
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0128	0.281
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0047	0.0083	0.2697
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Echinococcus multilocularis	potassium channel subfamily K	0.0103	0.0309	0.0184
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0083	0.1562
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0072	0.1248
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.0237	0.5839
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0043	0.0069	0.1157
Schistosoma mansoni	calcium-activated potassium channel	0.0103	0.0309	0.0242
Trypanosoma cruzi	hypothetical protein, conserved	0.0103	0.0309	0.7774
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0072	0.1248
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0103	0.0309	0.7576
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0103	0.0309	0.7576
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.0709	0.0671
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0083	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0039	0.032
Onchocerca volvulus		0.0103	0.0309	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0103	0.0309	0.7576
Loa Loa (eye worm)	TWK-7 protein	0.0103	0.0309	0.027
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0103	0.0309	0.7576
Leishmania major	hypothetical protein, conserved	0.0103	0.0309	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.0386	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0103	0.0309	0.7576
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.0386	1
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0103	0.0309	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0083	0.1562
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0043	0.0069	0.1157
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0103	0.0309	0.7576
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0058	0.0128	0.006
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0103	0.0309	0.7576
Leishmania major	hypothetical protein, conserved	0.0103	0.0309	1
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0103	0.0309	0.7774
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0103	0.0309	0.0184
Loa Loa (eye worm)	hypothetical protein	0.008	0.0218	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0309	0.027
Loa Loa (eye worm)	phosphatidylinositol 3	0.0058	0.0128	0.0088
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0103	0.0309	0.027
Entamoeba histolytica	hypothetical protein	0.0098	0.0289	0.6931
Echinococcus multilocularis	potassium channel subfamily K 8	0.0103	0.0309	0.0184
Onchocerca volvulus		0.0103	0.0309	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0072	0.1248
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.004	0.0356
Schistosoma mansoni	twik family of potassium channels-related	0.0103	0.0309	0.0242
Echinococcus granulosus	twik family of potassium channels	0.0103	0.0309	0.0184
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.0139	0.4112
Plasmodium falciparum	potassium channel	0.0103	0.0309	0.5
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0226	0.0807	0.0743
Plasmodium vivax	potassium channel, putative	0.0103	0.0309	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 161 nM	BindingDB_Patents: In Vitro Inhibition Assay. The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vitro setting. Active mTOR phosphorylates eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) on residue threonine 46. This phosphorylation event can be detected with a phospho-specific terbium (Tb) labeled Ab, in turn bringing the Tb label in close proximity to the GFP tagged 4E-BP1 and allowing for time-resolved fluorescence resonance energy transfer (TR-FRET), which correlates 4E-BP1 phosphorylation levels with mTOR kinase activity.	ChEMBL.	No reference
Ki (binding)	= 103 nM	BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein.	ChEMBL.	No reference
Ki (binding)	= 103 nM	BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3646567

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2003637