TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 280.28 | Formula: C12H16N4O4
H donors: 6 H acceptors: 6 LogP: -1.7 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H]1N[C@H](C([C@H]1O)O)c1c(C)nc2c1nc[nH]c2O
InChi: 1S/C12H16N4O4/c1-4-6(7-9(15-4)12(20)14-3-13-7)8-11(19)10(18)5(2-17)16-8/h3,5,8,10-11,16-20H,2H2,1H3,(H,13,14)/t5-,8+,10+,11?/m1/s1
InChiKey: ITTNZSXWLCIQSE-QISFDGGSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	purine nucleoside phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	Purine nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium ulcerans	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	ko:K03783 purine-nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	purine nucleoside phosphorylase	289 aa	255 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.1171	0.1171
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.1171	0.1171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.1171	0.1171
Echinococcus granulosus	nmda type glutamate receptor	0.0104	0.593	0.593
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0154	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.1171	0.1171
Echinococcus multilocularis	serotonin receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.1171	0.1171
Leishmania major	methylthioadenosine phosphorylase, putative	0.0032	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.1171	0.1171
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.1171	0.1585
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.1171	0.1585
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0032	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	amine GPCR	0.0046	0.1171	0.1171
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.1171	0.1171
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0	0.5
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus granulosus	g protein coupled receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.1171	0.1171
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.1171	0.1585
Echinococcus granulosus	glutamate receptor NMDA	0.0078	0.3784	0.3784
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0154	1	1
Brugia malayi	AKH receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.1171	0.1171
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0032	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	amine GPCR	0.0046	0.1171	0.1171
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	histamine h1 receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.1171	0.1171
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus granulosus	hypothetical protein	0.0046	0.1171	0.1171
Treponema pallidum	purine nucleoside phosphorylase (deoD)	0.0032	0	0.5
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Brugia malayi	G protein-coupled receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.1171	0.1585
Schistosoma mansoni	amine GPCR	0.0046	0.1171	0.1171
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.1171	0.1171
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.1171	0.1171
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.0046	0.1171	0.1171
Echinococcus multilocularis	nmda type glutamate receptor	0.0082	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Entamoeba histolytica	hypothetical protein	0.0032	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.1171	0.1171
Echinococcus granulosus	allatostatin A receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.1171	0.1585
Schistosoma mansoni	biogenic amine receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	glutamate receptor NMDA	0.0089	0.4695	0.4695
Schistosoma mansoni	biogenic amine receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	1	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Brugia malayi	neuropeptide F receptor	0.0046	0.1171	0.1171
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0154	1	1
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.1171	0.1585
Schistosoma mansoni	adenoreceptor	0.0046	0.1171	0.1171
Brugia malayi	Serotonin receptor	0.0046	0.1171	0.1171
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.1171	0.1171
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	hypothetical protein	0.0046	0.1171	0.1171
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.1171	0.1171
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	g protein coupled receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.1171	0.1171
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.1171	0.1171
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus granulosus	somatostatin receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.1171	0.1171
Echinococcus multilocularis	somatostatin receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0032	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0	0.5
Brugia malayi	larval opioid receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.1171	0.1171
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.1171	0.1585
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	hypothetical protein	0.0046	0.1171	0.1171
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.1171	0.1171
Plasmodium falciparum	purine nucleoside phosphorylase	0.0032	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Schistosoma mansoni	hypothetical protein	0.0046	0.1171	0.1171
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.1171	0.1171
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.1171	0.1171
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.1171	0.1171
Echinococcus granulosus	neuropeptide receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Schistosoma mansoni	myosin xvIII	0.0046	0.1171	0.1171
Toxoplasma gondii	phosphorylase family protein	0.0032	0	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.1171	0.1171
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0032	0	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Brugia malayi	sulfakinin receptor protein	0.0046	0.1171	0.1171
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0154	1	1
Chlamydia trachomatis	AMP nucleosidase	0.0032	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.1171	0.1171
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0032	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.1171	0.1171
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Schistosoma mansoni	opsin-like receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.1171	0.1171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Schistosoma mansoni	neuropeptide receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.1171	0.1171
Brugia malayi	neuropeptide F receptor	0.0046	0.1171	0.1171
Brugia malayi	putative neuropeptide receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.1171	0.1171
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.1171	0.1585
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.1171	0.1171
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	1	1
Schistosoma mansoni	amine GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.1171	0.1171
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0154	1	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0032	0	0.5
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.7389	0.7389
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Brugia malayi	RE15519p	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0122	0.7389	0.7389
Brugia malayi	Dopamine receptor protein 2	0.0046	0.1171	0.1171
Echinococcus granulosus	serotonin receptor	0.0046	0.1171	0.1171
Brugia malayi	G-protein coupled receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Trypanosoma brucei	uridine phosphorylase	0.0032	0	0.5
Echinococcus granulosus	nmda type glutamate receptor	0.0082	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.1171	0.1171
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0046	0.1171	0.1585
Echinococcus granulosus	neuropeptide receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	1	1
Brugia malayi	ORL1-like opioid receptor	0.0046	0.1171	0.1171
Brugia malayi	G-protein coupled receptor	0.0046	0.1171	0.1171
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.1171	0.1171
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.1171	0.1171
Brugia malayi	Serotonin receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	amine GPCR	0.0046	0.1171	0.1171
Echinococcus multilocularis	serotonin receptor	0.0046	0.1171	0.1171
Brugia malayi	GnHR receptor homolog	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	nmda type glutamate receptor	0.0104	0.593	0.593
Brugia malayi	Dopamine receptor	0.0046	0.1171	0.1171
Treponema pallidum	uridine phosphorylase (udp)	0.0032	0	0.5
Echinococcus granulosus	orexin receptor type 2	0.0046	0.1171	0.1171
Echinococcus multilocularis	glutamate receptor NMDA	0.0078	0.3784	0.3784
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	sex peptide receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Schistosoma mansoni	opsin-like receptor	0.0046	0.1171	0.1171
Brugia malayi	Dopamine receptor protein 1	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.1171	0.1171
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.1171	0.1171
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	sex peptide receptor	0.0046	0.1171	0.1171
Leishmania major	nucleoside phosphorylase-like protein	0.0032	0	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.1171	0.1171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Toxoplasma gondii	phosphorylase family protein	0.0032	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0	0.5
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0154	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.1171	0.1171
Schistosoma mansoni	opsin-like receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	neuropeptide receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.1171	0.1585
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.1171	0.1171
Schistosoma mansoni	neuropeptide receptor	0.0046	0.1171	0.1171
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Echinococcus granulosus	g protein coupled receptor	0.0046	0.1171	0.1171
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.1171	0.1171
Treponema pallidum	pfs protein (pfs)	0.0032	0	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.1171	0.1585
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0122	0.7389	1
Schistosoma mansoni	hypothetical protein	0.0046	0.1171	0.1171
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.1171	0.1171
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.7389	0.7389
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.1171	0.1171
Echinococcus granulosus	fmrfamide receptor	0.0046	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.1171	0.1171
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1171	0.1585
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.1171	0.1171
Schistosoma mansoni	biogenic amine receptor	0.0046	0.1171	0.1171
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.1171	0.1171
Brugia malayi	follicle stimulating hormone receptor	0.0046	0.1171	0.1171
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171
Brugia malayi	hypothetical protein	0.0046	0.1171	0.1171

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)		Inhibition of human purine nucleoside phosphorylase; Slow onset inhibition - Not determined.	ChEMBL.	12852771
Ki (binding)	= 10.1 nM	Inhibition of human purine nucleoside phosphorylase; Initial rate.	ChEMBL.	12852771
Ki (binding)	= 10.1 nM	Inhibition of human purine nucleoside phosphorylase; Initial rate.	ChEMBL.	12852771
ND (binding)	0	Inhibition of human purine nucleoside phosphorylase; Slow onset inhibition - Not determined.	ChEMBL.	12852771

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL114003

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 200972