Detailed information for compound 206556

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.342 | Formula: C19H17Cl2N5O2S--
  • H donors: 1 H acceptors: 5 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS(=O)(=O)c1ccc2c(c1)c(NCc1ccccc1)nc(n2)n1cncc1.[Cl-].[Cl-]
  • InChi: 1S/C19H17N5O2S.2ClH/c1-27(25,26)15-7-8-17-16(11-15)18(21-12-14-5-3-2-4-6-14)23-19(22-17)24-10-9-20-13-24;;/h2-11,13H,12H2,1H3,(H,21,22,23);2*1H/p-2
  • InChiKey: LZDXQGDLZHJYJN-UHFFFAOYSA-L  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0554 0.1791
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1767 0.5715
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.1367 0.1367
Loa Loa (eye worm) hypothetical protein 0.0039 0.0813 0.0813
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0288 1 1
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0074 0.2102 0.2102
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0343 0.1109
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Onchocerca volvulus Cathepsin L homolog 0.0054 0.1367 1
Giardia lamblia Cathepsin B precursor 0.0101 0.3093 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Echinococcus granulosus heat shock protein 90 0.0026 0.0343 0.0343
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0554 0.4054
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.1235 0.3994
Onchocerca volvulus 0.0054 0.1367 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0343 0.0343
Entamoeba histolytica cysteine protease, putative 0.0054 0.1367 1
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0589 0.0138
Loa Loa (eye worm) fibroinase 0.0054 0.1367 0.1367
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0343 0.1109
Onchocerca volvulus Cathepsin F homolog 0.0054 0.1367 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0248 0.0802
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0554 0.0554
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0589 0.431
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.1367 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1367 0.1367
Echinococcus multilocularis heat shock protein 0.0033 0.0589 0.0589
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0589 0.0138
Echinococcus granulosus cathepsin l1 0.0054 0.1367 0.1367
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.2102 0.2102
Echinococcus multilocularis heat shock protein 90 0.0026 0.0343 0.0343
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0813 0.5946
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.1367 0.1367
Trypanosoma brucei cysteine peptidase C (CPC) 0.0101 0.3093 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0582 0.1883
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Echinococcus multilocularis endoplasmin 0.0026 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0288 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.1367 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.2102 0.6796
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1367 0.1367
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.2102 0.6096
Brugia malayi Cathepsin L-like precursor 0.0039 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0554 0.4054
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Toxoplasma gondii cathepsin B 0.0101 0.3093 1
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0589 0.1904
Echinococcus granulosus heat shock protein 0.0033 0.0589 0.0589
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0554 0.4054
Brugia malayi Cathepsin L-like precursor 0.0054 0.1367 0.1367
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0554 0.4054
Trichomonas vaginalis heat shock protein, putative 0.002 0.0122 0.0395
Plasmodium vivax vivapain-2 0.0054 0.1367 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Echinococcus multilocularis cathepsin b 0.0288 1 1
Echinococcus multilocularis heat shock protein 90 0.0033 0.0589 0.0589
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0582 0.0582
Echinococcus granulosus cathepsin l1 0.0039 0.0813 0.0813
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0554 0.0554
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0554 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1767 0.5715
Brugia malayi cathepsin L-like precursor 0.0039 0.0813 0.0813
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0343 0.1109
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0094 0.0094
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.1367 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.1367 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0582 0.1883
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0582 0.0582
Echinococcus granulosus cathepsin b 0.0288 1 1
Brugia malayi Cathepsin L-like precursor 0.0054 0.1367 0.1367
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1767 0.5715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Brugia malayi Cathepsin L-like precursor 0.0054 0.1367 0.1367
Echinococcus granulosus cathepsin L 0.0032 0.0554 0.0554
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0589 0.1904
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0248 0.1815
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0589 0.1904
Echinococcus granulosus endoplasmin 0.0026 0.0343 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.1367 0.1367
Schistosoma mansoni endoplasmin 0.0033 0.0589 0.0589
Echinococcus granulosus cysteine protease 0.0032 0.0554 0.0554
Onchocerca volvulus 0.0054 0.1367 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Loa Loa (eye worm) ctsf protein 0.0054 0.1367 0.1367
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.3093 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Loa Loa (eye worm) hypothetical protein 0.0039 0.0813 0.0813
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0813 0.0813
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0554 0.0554
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Schistosoma mansoni endoplasmin 0.0033 0.0589 0.0589
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.2102 0.2102
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.2102 0.6796
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.2102 0.2102
Plasmodium vivax vivapain-1 0.0032 0.0554 0.4054
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0582 0.0582
Echinococcus multilocularis cysteine protease 0.0054 0.1367 0.1367
Toxoplasma gondii cathepsin CPL 0.0054 0.1367 0.4419
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.003 0.0494 1
Plasmodium vivax vivapain-2 0.0054 0.1367 1
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Onchocerca volvulus 0.0054 0.1367 1
Treponema pallidum heat shock protein 90 0.0026 0.0343 0.5
Leishmania major cysteine peptidase A (CPA) 0.0054 0.1367 0.3723
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0554 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0248 0.0802
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0554 0.0554
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0589 0.0589
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0589 0.0589
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Giardia lamblia Cathepsin B precursor 0.0101 0.3093 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.1367 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Brugia malayi Endoplasmin precursor 0.0033 0.0589 0.0589
Loa Loa (eye worm) cysteine protease 0.0054 0.1367 0.1367
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0343 0.3862
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0813 0.0813
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1367 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Onchocerca volvulus 0.0054 0.1367 1
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0343 0.0343
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.1367 1
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Giardia lamblia Grp94/Hsp90 0.0026 0.0343 0.1109
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0288 1 1
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.1367 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.1367 0.4419
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0582 0.1883
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0554 0.4054
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.1367 0.1367
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.1367 0.1367
Brugia malayi Cathepsin L-like precursor 0.0054 0.1367 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0554 0.0554
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1367 0.1367
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0589 0.0589
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0248 0.1815
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0074 0.2102 0.2102
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0101 0.3093 0.3093
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Onchocerca volvulus 0.0054 0.1367 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Echinococcus granulosus heat shock protein 90 0.0033 0.0589 0.0589
Brugia malayi Cathepsin L-like precursor 0.0054 0.1367 0.1367
Brugia malayi Cathepsin L-like precursor 0.0054 0.1367 0.1367
Loa Loa (eye worm) cathepsin B 0.0101 0.3093 0.3093
Schistosoma mansoni heat shock protein 0.0033 0.0589 0.0589
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0589 0.1904
Loa Loa (eye worm) hypothetical protein 0.0033 0.0582 0.0582
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.1367 0.1367
Onchocerca volvulus 0.0039 0.0813 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0813 0.2627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0343 1
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Schistosoma mansoni heat shock protein 0.0033 0.0589 0.0589
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0554 0.0554
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Plasmodium vivax vivapain-3 0.0032 0.0554 0.4054
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.003 0.0494 1
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0589 0.0138
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0343 0.5
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.003 0.0494 1
Trichomonas vaginalis endoplasmin, putative 0.002 0.0122 0.0395
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.1367 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Echinococcus multilocularis cysteine protease 0.0054 0.1367 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Plasmodium falciparum endoplasmin, putative 0.002 0.0122 0.0894
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.1235 0.3994
Echinococcus granulosus cathepsin b 0.0288 1 1
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trypanosoma brucei heat shock protein, putative 0.0033 0.0589 0.0138
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0582 0.0582
Toxoplasma gondii hypothetical protein 0.0023 0.0248 0.0802
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0554 0.0554
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0589 0.431
Brugia malayi heat shock protein 90 0.0033 0.0589 0.0589
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0554 0.4054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0813 0.0813
Onchocerca volvulus Cathepsin L homolog 0.0054 0.1367 1
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Giardia lamblia Cathepsin B precursor 0.0101 0.3093 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0813 0.2627
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0582 0.0582
Onchocerca volvulus 0.0054 0.1367 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0343 0.1109
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0554 0.0554
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0554 0.0554
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0074 0.2102 0.2102
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0589 0.0589
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0554 0.1791
Brugia malayi Cathepsin L-like precursor 0.0039 0.0813 0.0813
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.1235 0.1235
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0039 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0023 0.0248 0.0248
Entamoeba histolytica cysteine protease, putative 0.0032 0.0554 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Leishmania major cathepsin L-like protease 0.0054 0.1367 0.3723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1367 0.4419
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1367 0.1367
Plasmodium vivax endoplasmin, putative 0.0033 0.0589 0.431
Toxoplasma gondii hypothetical protein 0.0065 0.1767 0.5715
Plasmodium falciparum heat shock protein 90 0.0033 0.0589 0.431
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.1367 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0554 0.0554
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0101 0.3093 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Plasmodium vivax unspecified product 0.0032 0.0554 0.4054
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.2102 0.6096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1367 0.4419
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.2102 0.6796
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.2102 0.6796
Loa Loa (eye worm) endoplasmin 0.0033 0.0589 0.0589
Onchocerca volvulus 0.0054 0.1367 1
Toxoplasma gondii hypothetical protein 0.0023 0.0248 0.0802
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 1 1
Echinococcus multilocularis cathepsin b 0.0288 1 1
Echinococcus multilocularis cathepsin L 0.0032 0.0554 0.0554
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.1367 0.1367
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.2102 0.6796
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0589 0.431
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0343 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1367 0.3201
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0589 0.0589
Leishmania major heat shock protein 83-1 0.0033 0.0589 0.0894
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.1367 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.3093 0.3093

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.11 uM Inhibitory activity against phosphodiesterase 5 from human platelets ChEMBL. 7658441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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