Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 259 aa | 254 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0189 | 0 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0467 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0467 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0467 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.4536 | 0.4536 |
Leishmania major | adenine aminohydrolase | 0.0467 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0467 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0189 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.4536 | 0.4536 |
Schistosoma mansoni | adenosine deaminase-related | 0.0467 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0467 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0467 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0467 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0467 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0467 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0467 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0467 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0467 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0467 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0467 | 1 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0189 | 0 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0467 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.4536 | 0.4536 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.4536 | 0.4536 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0467 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -7.03 | Log of inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone. | ChEMBL. | 15214782 |
IC50 (binding) | = 93 nM | Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone. | ChEMBL. | 15214782 |
IC50 (binding) | = 93 nM | Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone. | ChEMBL. | 15214782 |
Log IC50 (binding) | = 7.03 | Log of inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone. | ChEMBL. | 15214782 |
logP (ADMET) | = 5.35 | Partition coefficient (logP) | ChEMBL. | 15214782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.