Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.3448 | 0.5946 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0101 | 0.2444 | 0.2444 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0188 | 0.5599 | 1 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Onchocerca volvulus | 0.0188 | 0.5599 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0161 | 0.4622 | 0.4622 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0188 | 0.5599 | 0.5467 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0041 | 0.0292 | 0.0522 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0101 | 0.2444 | 0.2444 |
Brugia malayi | Cathepsin L-like precursor | 0.0059 | 0.0943 | 0.067 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Schistosoma mansoni | cathepsin C | 0.0041 | 0.0292 | 0.0292 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0101 | 0.2444 | 0.2216 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Schistosoma mansoni | cathepsin S (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0188 | 0.5599 | 0.5467 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0188 | 0.5599 | 1 |
Toxoplasma gondii | cathepsin CPC1 | 0.0041 | 0.0292 | 0.0522 |
Echinococcus multilocularis | cathepsin b | 0.0309 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Echinococcus multilocularis | geminin | 0.0161 | 0.4622 | 0.4622 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.3448 | 0.325 |
Plasmodium vivax | vivapain-3 | 0.0101 | 0.2444 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Plasmodium vivax | vivapain-2 | 0.0188 | 0.5599 | 1 |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0101 | 0.2444 | 0.2444 |
Echinococcus granulosus | cathepsin L | 0.0101 | 0.2444 | 0.2444 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0063 | 0.1073 | 0.1073 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0309 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0101 | 0.2444 | 0.2216 |
Echinococcus granulosus | cathepsin b | 0.0309 | 1 | 1 |
Onchocerca volvulus | 0.0188 | 0.5599 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0059 | 0.0943 | 0.067 |
Echinococcus multilocularis | cathepsin b | 0.0309 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0188 | 0.5599 | 0.5467 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0059 | 0.0943 | 0.067 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0188 | 0.5599 | 0.5467 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0129 | 0.3448 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0124 | 0.3295 | 0.5658 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.3448 | 0.325 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0188 | 0.5599 | 1 |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0124 | 0.3295 | 0.3295 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0101 | 0.2444 | 0.4054 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0033 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Echinococcus granulosus | cathepsin b | 0.0309 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0101 | 0.2444 | 0.2444 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0101 | 0.2444 | 0.2216 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.5599 | 0.5467 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0188 | 0.5599 | 0.5599 |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Onchocerca volvulus | 0.0188 | 0.5599 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0033 | 0 | 0.5 |
Onchocerca volvulus | 0.0188 | 0.5599 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0188 | 0.5599 | 1 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0063 | 0.1073 | 0.1073 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0188 | 0.5599 | 0.5599 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0101 | 0.2444 | 0.4054 |
Brugia malayi | cathepsin L-like precursor | 0.0129 | 0.3448 | 0.325 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0101 | 0.2444 | 0.4054 |
Loa Loa (eye worm) | ctsf protein | 0.0188 | 0.5599 | 0.5467 |
Echinococcus multilocularis | cysteine protease | 0.0188 | 0.5599 | 0.5599 |
Schistosoma mansoni | cathepsin s | 0.0059 | 0.0943 | 0.0943 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0188 | 0.5599 | 0.5599 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0943 | 0.067 |
Schistosoma mansoni | cathepsin B (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Echinococcus multilocularis | caspase | 0.0063 | 0.1073 | 0.1073 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.3448 | 0.5946 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0063 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.3448 | 0.325 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0101 | 0.2444 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.5599 | 0.5467 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0101 | 0.2444 | 0.2216 |
Echinococcus granulosus | cathepsin l1 | 0.0129 | 0.3448 | 0.3448 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0124 | 0.3295 | 0.5884 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0188 | 0.5599 | 0.5599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0059 | 0.0943 | 0.067 |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0059 | 0.0943 | 0.067 |
Toxoplasma gondii | cathepsin B | 0.0124 | 0.3295 | 0.5884 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0101 | 0.2444 | 0.2216 |
Plasmodium vivax | vivapain-1 | 0.0101 | 0.2444 | 0.4054 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0188 | 0.5599 | 0.5599 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0101 | 0.2444 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0129 | 0.3448 | 0.3448 |
Onchocerca volvulus | 0.0188 | 0.5599 | 1 | |
Onchocerca volvulus | 0.0129 | 0.3448 | 0.5946 | |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.5599 | 0.5467 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Echinococcus granulosus | cysteine protease | 0.0101 | 0.2444 | 0.2444 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0101 | 0.2444 | 0.4054 |
Echinococcus multilocularis | cathepsin L | 0.0041 | 0.0292 | 0.0292 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0188 | 0.5599 | 0.5599 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0101 | 0.2444 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0124 | 0.3295 | 0.2697 |
Echinococcus granulosus | caspase | 0.0063 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0943 | 0.067 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0309 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0041 | 0.0292 | 0.0292 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.5599 | 0.5467 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0101 | 0.2444 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0188 | 0.5599 | 0.5467 |
Schistosoma mansoni | subfamily C1A non-peptidase homologue (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0309 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0101 | 0.2444 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0309 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0309 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0124 | 0.3295 | 0.3093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0188 | 0.5599 | 0.5467 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0188 | 0.5599 | 0.5467 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0188 | 0.5599 | 0.5599 |
Trypanosoma cruzi | cysteine protease, putative | 0.0101 | 0.2444 | 0.2216 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0943 | 0.067 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0129 | 0.3448 | 0.325 |
Schistosoma mansoni | hypothetical protein | 0.0161 | 0.4622 | 0.4622 |
Loa Loa (eye worm) | fibroinase | 0.0188 | 0.5599 | 0.5467 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0101 | 0.2444 | 0.2216 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.3448 | 0.325 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Plasmodium vivax | unspecified product | 0.0101 | 0.2444 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.5599 | 0.5467 |
Echinococcus granulosus | caspase 3 | 0.0046 | 0.0463 | 0.0463 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0101 | 0.2444 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Entamoeba histolytica | cysteine protease, putative | 0.0188 | 0.5599 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0188 | 0.5599 | 0.5599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Echinococcus granulosus | geminin | 0.0161 | 0.4622 | 0.4622 |
Onchocerca volvulus | 0.0188 | 0.5599 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0188 | 0.5599 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0063 | 0.1073 | 0.1073 |
Toxoplasma gondii | cathepsin CPC2 | 0.0041 | 0.0292 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.3448 | 0.325 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0188 | 0.5599 | 1 |
Leishmania major | cathepsin L-like protease | 0.0188 | 0.5599 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0059 | 0.0943 | 0.067 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0102 | 0.2469 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0124 | 0.3295 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0188 | 0.5599 | 1 |
Plasmodium vivax | unspecified product | 0.0059 | 0.0943 | 0.1225 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.5599 | 0.5467 |
Giardia lamblia | Cathepsin B precursor | 0.0124 | 0.3295 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Onchocerca volvulus | 0.0188 | 0.5599 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0188 | 0.5599 | 0.5599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0129 | 0.3448 | 0.325 |
Giardia lamblia | Cathepsin B precursor | 0.0124 | 0.3295 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0033 | 0 | 0.5 |
Leishmania major | cysteine peptidase A (CPA) | 0.0188 | 0.5599 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0188 | 0.5599 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0188 | 0.5599 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0124 | 0.3295 | 0.3093 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0101 | 0.2444 | 0.2444 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0188 | 0.5599 | 0.5467 |
Onchocerca volvulus | Cathepsin F homolog | 0.0188 | 0.5599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0188 | 0.5599 | 0.5467 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0188 | 0.5599 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0188 | 0.5599 | 0.5599 |
Echinococcus multilocularis | caspase 3 | 0.0046 | 0.0463 | 0.0463 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.5599 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0041 | 0.0292 | 0.0292 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.5599 | 0.5467 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.