Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.1297 | 0.1297 |
Brugia malayi | hypothetical protein | 0.0188 | 0.571 | 0.571 |
Echinococcus granulosus | jun protein | 0.0097 | 0.2669 | 0.3087 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0018 | 0.0053 | 0.0053 |
Echinococcus granulosus | single minded 2 | 0.0041 | 0.0827 | 0.0913 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.2065 | 0.2022 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0018 | 0.0053 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0761 | 0.0711 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0054 | 0.0054 |
Onchocerca volvulus | 0.0056 | 0.1297 | 0.5456 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0826 | 0.0912 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0481 | 0.0481 |
Leishmania major | cytochrome p450-like protein | 0.0018 | 0.0053 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0272 | 0.8522 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.137 | 0.137 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0097 | 0.2669 | 0.3087 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0761 | 0.0761 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0481 | 0.0481 |
Brugia malayi | hypothetical protein | 0.0272 | 0.8522 | 0.8522 |
Brugia malayi | bZIP transcription factor family protein | 0.0097 | 0.2669 | 0.2669 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0761 | 0.0761 |
Brugia malayi | PAS domain containing protein | 0.0056 | 0.1313 | 0.1313 |
Echinococcus multilocularis | jun protein | 0.0097 | 0.2669 | 0.3087 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0481 | 0.0503 |
Loa Loa (eye worm) | glutaminase 2 | 0.0317 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.0317 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0481 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.8522 | 0.8522 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0018 | 0.0053 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0056 | 0.1313 | 0.1265 |
Trypanosoma brucei | cytochrome P450, putative | 0.0018 | 0.0053 | 0.5 |
Echinococcus granulosus | lamin | 0.0031 | 0.0481 | 0.0503 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0053 | 0.0053 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0041 | 0.0827 | 0.0913 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.137 | 0.137 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0826 | 0.0826 |
Loa Loa (eye worm) | glutaminase | 0.0317 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0317 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0826 | 0.0776 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0826 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0481 | 0.0481 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0826 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0826 | 0.0912 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.0053 | 0.0053 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0481 | 0.0481 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1297 | 0.1249 |
Brugia malayi | hypoxia-induced factor 1 | 0.0173 | 0.5225 | 0.5225 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.0053 | 0.0053 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0481 | 0.0503 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.1297 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0054 | 0.0054 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0053 | 0.0053 |
Schistosoma mansoni | single-minded | 0.0056 | 0.1313 | 0.1265 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.137 | 0.137 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0097 | 0.2669 | 0.3087 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0173 | 0.5225 | 0.5225 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0462 | 0.0462 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0826 | 0.0776 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0481 | 0.0428 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0481 | 0.0503 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0481 | 0.0481 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0272 | 0.8522 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0317 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0826 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0481 | 0.0428 |
Mycobacterium ulcerans | putative regulatory protein | 0.0041 | 0.0827 | 0.0778 |
Schistosoma mansoni | jun-related protein | 0.0079 | 0.2065 | 0.2022 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.137 | 0.137 |
Onchocerca volvulus | 0.0076 | 0.1977 | 1 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0054 | 0.0054 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0481 | 0.0503 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.045 | 0.045 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0826 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0481 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.258 | 0.258 |
Onchocerca volvulus | 0.0041 | 0.0827 | 0.2319 | |
Brugia malayi | hypothetical protein | 0.0076 | 0.1977 | 0.1977 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.045 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.571 | 0.571 |
Brugia malayi | bHLH-PAS transcription factor | 0.0041 | 0.0827 | 0.0827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.