Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8749 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0246 | 0.8564 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0246 | 0.8564 | 0.5 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0246 | 0.8564 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.5999 | 0.7005 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7066 | 0.8251 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.5999 | 0.849 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.5999 | 0.6857 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0991 | 0.6407 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.0381 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0.0381 | 0.0445 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0246 | 0.8564 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7066 | 0.8251 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1392 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1547 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.0381 | 0.0436 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0073 | 0.0084 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0991 | 0.1157 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1392 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0943 | 0.1335 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8749 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1392 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0991 | 0.1403 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.0381 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1547 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1547 | 0.2189 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.0381 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0991 | 0.1157 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.0381 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0991 | 0.1133 |
Echinococcus granulosus | geminin | 0.0205 | 0.7066 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1547 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.5822 | 0.824 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0991 | 0.1403 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0246 | 0.8564 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0991 | 0.1157 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0991 | 0.1403 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.5999 | 0.6857 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0991 | 0.1157 |
Echinococcus multilocularis | geminin | 0.0205 | 0.7066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0991 | 0.1133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.