Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0021 | 0.0391 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.0021 | 0.0391 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0016 | 0.024 | 0.6145 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0028 | 0.0636 | 1 |
Onchocerca volvulus | 0.0021 | 0.0391 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.024 | 0.024 |
Brugia malayi | FXNA | 0.0021 | 0.0391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.6542 | 0.6542 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0021 | 0.0391 | 0.0391 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0021 | 0.0391 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0391 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0231 | 0.0231 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0021 | 0.0391 | 0.0158 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0391 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0391 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0021 | 0.0391 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0021 | 0.0391 | 0.0249 |
Schistosoma mansoni | nicalin (M28 family) | 0.0021 | 0.0391 | 0.0249 |
Toxoplasma gondii | hypothetical protein | 0.0021 | 0.0391 | 0.5 |
Brugia malayi | nicalin | 0.0021 | 0.0391 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0021 | 0.0391 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0021 | 0.0391 | 1 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0391 | 0.0158 |
Brugia malayi | leucyl aminopeptidase | 0.0021 | 0.0391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0391 | 0.0391 |
Brugia malayi | intermediate filament protein | 0.0016 | 0.024 | 0.6145 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0021 | 0.0391 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0021 | 0.0391 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0021 | 0.0391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0391 | 0.0391 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0021 | 0.0391 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0391 | 0.0158 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0391 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0016 | 0.024 | 0.024 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0203 | 0.6297 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0021 | 0.0391 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0021 | 0.0391 | 0.0249 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0.0391 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0028 | 0.0636 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0016 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.9087 | 0.9087 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0391 | 0.0391 |
Leishmania major | glutaminyl cyclase, putative | 0.0021 | 0.0391 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0391 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0309 | 0.9755 | 1 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0021 | 0.0391 | 0.0249 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.