Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.4117 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.173 | 0.4202 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0179 | 0.5273 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0039 | 0.0048 | 0.5 |
Brugia malayi | Beta-glucuronidase precursor | 0.0098 | 0.2238 | 0.2548 |
Echinococcus granulosus | beta galactosidase | 0.0129 | 0.3408 | 0.6795 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0096 | 0.2178 | 0.4343 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.2544 | 0.6179 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.5015 | 0.5015 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0062 | 0.0896 | 0.1788 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.5273 | 0.6002 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.0896 | 0.102 |
Echinococcus multilocularis | acetylcholinesterase | 0.0096 | 0.2178 | 0.4343 |
Brugia malayi | manba-prov protein | 0.0168 | 0.489 | 0.5566 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.5015 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.8786 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.4117 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.8786 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.0896 | 0.102 |
Brugia malayi | Carboxylesterase family protein | 0.0096 | 0.2178 | 0.2479 |
Schistosoma mansoni | beta-mannosidase | 0.0071 | 0.1222 | 0.2967 |
Echinococcus granulosus | acetylcholinesterase | 0.0096 | 0.2178 | 0.4343 |
Loa Loa (eye worm) | carboxylesterase | 0.0096 | 0.2178 | 0.2178 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.173 | 0.173 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0062 | 0.0896 | 0.1788 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0062 | 0.0896 | 0.1788 |
Mycobacterium ulcerans | hypothetical protein | 0.0114 | 0.2853 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0103 | 0.2418 | 0.3609 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0096 | 0.2178 | 0.529 |
Schistosoma mansoni | beta-galactosidase | 0.0129 | 0.3408 | 0.8277 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.8786 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0217 | 0.6701 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.017 | 0.4936 | 0.9843 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.4936 | 0.4936 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0272 | 0.8786 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0272 | 0.8786 | 0.8786 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.017 | 0.4936 | 0.9843 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.173 | 0.345 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.5273 | 0.6002 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.173 | 0.1969 |
Echinococcus multilocularis | beta mannosidase | 0.0071 | 0.1222 | 0.2436 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.3408 | 0.3408 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.5015 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.173 | 0.345 |
Echinococcus granulosus | beta mannosidase | 0.0071 | 0.1222 | 0.2436 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.6213 | 0.7071 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0114 | 0.2853 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.5273 | 0.6002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.5273 | 0.6002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.5634 | 0.6412 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.0896 | 0.2177 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0106 | 0.2544 | 1 |
Loa Loa (eye worm) | manba-prov protein | 0.0071 | 0.1222 | 0.1222 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0217 | 0.6701 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0096 | 0.2178 | 0.4343 |
Brugia malayi | Carboxylesterase family protein | 0.0096 | 0.2178 | 0.2479 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.5634 | 0.6412 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0204 | 0.6213 | 0.7071 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0098 | 0.2238 | 0.2238 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.5273 | 0.6002 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2178 | 0.2178 |
Echinococcus granulosus | acetylcholinesterase | 0.0096 | 0.2178 | 0.4343 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0896 | 0.0896 |
Schistosoma mansoni | jumonji domain containing protein | 0.0062 | 0.0896 | 0.2177 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0103 | 0.2418 | 0.3609 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2178 | 0.2178 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0106 | 0.2544 | 0.2896 |
Echinococcus multilocularis | beta galactosidase | 0.0129 | 0.3408 | 0.6795 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0062 | 0.0896 | 0.1788 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0048 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.0896 | 0.2177 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0106 | 0.2544 | 0.2544 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.3408 | 0.3408 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0204 | 0.6213 | 0.7071 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0217 | 0.6701 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.8786 | 1 |
Onchocerca volvulus | 0.0099 | 0.2297 | 0.1601 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0103 | 0.2418 | 0.3609 |
Trichomonas vaginalis | beta-mannosidase, putative | 0.0071 | 0.1222 | 0.139 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.8786 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.5015 | 0.5708 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0217 | 0.6701 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.5273 | 0.6002 |
Brugia malayi | hypothetical protein | 0.017 | 0.4936 | 0.5618 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.8786 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.5273 | 0.6002 |
Echinococcus granulosus | carboxylesterase 5A | 0.0096 | 0.2178 | 0.4343 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0096 | 0.2178 | 0.2178 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.5015 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.