Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0308 | 0.6156 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.047 | 1 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0308 | 0.6156 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0308 | 0.6156 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.047 | 1 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0308 | 0.6156 | 1 |
Onchocerca volvulus | 0.0308 | 0.6156 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.6156 | 0.6156 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0308 | 0.6156 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.047 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0308 | 0.6156 | 0.6156 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0308 | 0.6156 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.047 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0308 | 0.6156 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0308 | 0.6156 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0308 | 0.6156 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.047 | 1 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0308 | 0.6156 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.047 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.6156 | 0.6156 |
Plasmodium vivax | polyprenol reductase, putative | 0.0308 | 0.6156 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.047 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.047 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.047 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.047 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | Drug level assessed as recombinant human CYP3A5-mediated compound formation treated with lapatinib at 50 uM after 60 mins by GSH trapping assay in presence of NADPH | ChEMBL. | 22511346 | |
Drug metabolism (ADMET) | Drug level assessed as recombinant human CYP3A5-mediated compound formation treated with O-dealkylated lapatinib at 50 uM after 60 mins by GSH trapping assay in presence of NADPH | ChEMBL. | 22511346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.