Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0675 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0675 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0675 | 1 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | 0.0101 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | 0.0101 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0101 | 0 | 0.5 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0101 | 0 | 0.5 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0675 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0101 | 0 | 0.5 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0101 | 0 | 0.5 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 0 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0675 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.3 | The inotropic effect tested in vitro by using isolated blood-perfused dog heart preparations | ChEMBL. | 1331445 |
Activity (functional) | = 4.3 | The chronotropic effect tested in vitro by using isolated blood-perfused dog heart preparations | ChEMBL. | 1331445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.