Detailed information for compound 210779

Basic information

Technical information
  • TDR Targets ID: 210779
  • Name: N-[(2S)-3-[cyclopentylmethyl-(4-methoxyphenyl )sulfonylamino]-2-hydroxypropyl]-N-phenethyl- 2-phenylacetamide
  • MW: 564.735 | Formula: C32H40N2O5S
  • H donors: 1 H acceptors: 4 LogP: 5.3 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)S(=O)(=O)N(CC1CCCC1)C[C@H](CN(C(=O)Cc1ccccc1)CCc1ccccc1)O
  • InChi: 1S/C32H40N2O5S/c1-39-30-16-18-31(19-17-30)40(37,38)34(23-28-14-8-9-15-28)25-29(35)24-33(21-20-26-10-4-2-5-11-26)32(36)22-27-12-6-3-7-13-27/h2-7,10-13,16-19,28-29,35H,8-9,14-15,20-25H2,1H3/t29-/m0/s1
  • InChiKey: ZUOLTJOTYNLDSA-LJAQVGFWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2S)-3-[cyclopentylmethyl-(4-methoxyphenyl)sulfonyl-amino]-2-hydroxy-propyl]-N-phenethyl-2-phenyl-acetamide
  • N-[(2S)-3-[cyclopentylmethyl-(4-methoxyphenyl)sulfonyl-amino]-2-hydroxy-propyl]-N-phenethyl-2-phenyl-ethanamide
  • N-[(2S)-3-[cyclopentylmethyl-(4-methoxyphenyl)sulfonylamino]-2-hydroxypropyl]-2-phenyl-N-(2-phenylethyl)acetamide
  • N-[(2S)-3-[cyclopentylmethyl-(4-methoxyphenyl)sulfonyl-amino]-2-hydroxy-propyl]-2-phenyl-N-(2-phenylethyl)acetamide
  • N-[(2S)-3-[cyclopentylmethyl-(4-methoxyphenyl)sulfonyl-amino]-2-hydroxy-propyl]-2-phenyl-N-(2-phenylethyl)ethanamide
  • AIDS-082050
  • AIDS082050
  • N-((2S)-3-{(Cyclopentylmethyl)[(4-methoxyphenyl)sulfonyl]amino}-2-hydroxypropyl)-2-phenyl-N-(2-phenylethyl)acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0754 0.4905 1
Echinococcus granulosus voltage dependent calcium channel subunit 0.0357 0.229 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0354 0.0722
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0154 0.0674
Brugia malayi hypothetical protein 0.0027 0.012 0.0244
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0008
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0375 0.1638
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0008
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0156 0.0967 0.0967
Echinococcus multilocularis global transcription activator snf2l2 0.0071 0.0414 0.1807
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.012 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0154 0.0674
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0034
Brugia malayi Cache domain containing protein 0.0072 0.0416 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0044 0.0232 0.0473
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0025 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0012 0.0023 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0154 0.0674
Echinococcus multilocularis hypothetical protein 0.0019 0.0066 0.0286
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0232 0.1473 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.0084 0.0495 0.0495
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0154 0.0315
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0034
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0357 0.229 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0016
Echinococcus granulosus calpain 5 0.0019 0.0066 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0235 0.1026
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.1094 0.2231
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0034
Brugia malayi N-terminal motif family protein 0.0175 0.1094 0.2231
Onchocerca volvulus 0.0044 0.0232 0.0473
Loa Loa (eye worm) hypothetical protein 0.0072 0.0416 0.0848
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0232 0.0473
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0034
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0034
Leishmania major hypothetical protein, conserved 0.0232 0.1473 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0235 0.1026
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0017 0.1388
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.0386
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0235 0.0235
Leishmania major hypothetical protein, conserved 0.0027 0.012 0.0386
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0232 0.1473 0.2961
Brugia malayi calpain family protein 1 0.0062 0.0354 0.0722
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.0025 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0175 0.1094 0.2231
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0232 0.1473 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0034
Echinococcus multilocularis calpain 0.0019 0.0066 0.0286
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0066 0.0066
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0235 0.0479
Schistosoma mansoni hypothetical protein 0.0032 0.0154 0.0154
Schistosoma mansoni helicase 0.0071 0.0414 0.0414
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0008
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0754 0.4905 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0016
Echinococcus granulosus voltage dependent calcium channel subunit 0.0162 0.1011 0.4413
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0025 0.0051
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0078 0.0459 0.0459
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0025 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0016
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0754 0.4905 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0023 0.0098
Echinococcus multilocularis Chromo domain 0.0012 0.0025 0.0109
Loa Loa (eye worm) BRM protein 0.0037 0.0187 0.0381
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0025 0.0108
Onchocerca volvulus 0.001 0.0008 0.0016
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0754 0.4905 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0399 0.0814
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0754 0.4905 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0754 0.4905 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.0399 0.0814
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0232 0.1473 1
Plasmodium vivax calpain, putative 0.0019 0.0066 0.4737
Echinococcus granulosus calpain A 0.0019 0.0066 0.0286
Loa Loa (eye worm) hypothetical protein 0.0101 0.061 0.1244
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0016
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0008
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0066 0.0066
Echinococcus granulosus Chromo domain 0.0012 0.0025 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0034
Loa Loa (eye worm) hypothetical protein 0.0062 0.0354 0.0722
Loa Loa (eye worm) hypothetical protein 0.0027 0.012 0.0244
Brugia malayi calpain 5 0.0019 0.0066 0.0134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0154 0.0674
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0034
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.0025 0.0051
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.012 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0235 0.1026
Loa Loa (eye worm) hypothetical protein 0.0044 0.0232 0.0473
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0034
Loa Loa (eye worm) calpain family protein 1 0.0062 0.0354 0.0722
Echinococcus granulosus global transcription activator snf2l2 0.0071 0.0414 0.1807
Entamoeba histolytica hypothetical protein 0.0105 0.0636 0.1179
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0754 0.4905 1
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0016
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0025 0.0108
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.012 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.0386
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0162 0.1011 0.4413
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0008
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0232 0.1012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0034
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0008
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.012 0.0386
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0105 0.0636 0.1179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0016
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0016
Echinococcus multilocularis GPCR, family 2 0.0032 0.0154 0.0674
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0754 0.4905 1
Schistosoma mansoni hypothetical protein 0.0032 0.0154 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0016
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0375 0.0375
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.061 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.061 0.1244
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0754 0.4905 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0754 0.4905 1
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0008
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0354 0.0354
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0066 0.0286
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.1772 0.1772
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Schistosoma mansoni calpain (C02 family) 0.0019 0.0066 0.0066
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0016
Brugia malayi calpain family protein 1 0.0062 0.0354 0.0722
Echinococcus multilocularis calpain A 0.0066 0.0375 0.1638
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.037 0.2378 0.4779
Echinococcus multilocularis calpain 5 0.0019 0.0066 0.0286
Schistosoma mansoni hypothetical protein 0.0069 0.0399 0.0399
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0025 0.0108
Echinococcus granulosus BRK domain containing protein 0.0012 0.0025 0.0108
Echinococcus multilocularis BRK domain 0.0012 0.0025 0.0108
Brugia malayi calpain 7 0.0019 0.0066 0.0134
Echinococcus granulosus calpain 0.0019 0.0066 0.0286
Loa Loa (eye worm) BRM protein 0.0046 0.0244 0.0497
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.0032 0.0154 0.0154
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) calpain 5 0.0019 0.0066 0.0134
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0008
Onchocerca volvulus 0.0754 0.4905 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0375 0.1638
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.061 0.1244
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0023 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0235 0.0235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0235 0.1026
Echinococcus granulosus GPCR family 2 0.0032 0.0154 0.0674
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0016
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0016
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0066 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0235 0.0479
Schistosoma mansoni serine-rich repeat protein 0.0084 0.0495 0.0495
Loa Loa (eye worm) calpain 0.0019 0.0066 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0235 0.0235
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0754 0.4905 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0154 0.0315
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0025 0.0108
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0232 0.1473 0.2961
Echinococcus granulosus calpain A 0.0066 0.0375 0.1638
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0754 0.4905 1
Schistosoma mansoni hypothetical protein 0.0032 0.0154 0.0154
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0154 0.0315
Brugia malayi BRM protein 0.0071 0.0414 0.0844
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.012 1
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0029 0.2425
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0375 0.0375
Brugia malayi hypothetical protein 0.0017 0.0057 0.0117
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0521 0.3375 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0034
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0154 0.0315
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0016

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 20 nM Binding affinity to HIV-1 protease was determined ChEMBL. 9934484
Ki (binding) = 20 nM Binding affinity to HIV-1 protease was determined ChEMBL. 9934484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.