Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | rac gtpase activating protein | 0.0192 | 0.0864 | 0.0844 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1761 | 1 | 1 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0192 | 0.0864 | 0.6414 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1569 | 0.888 | 0.8877 |
Entamoeba histolytica | protein kinase, putative | 0.0274 | 0.1337 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0192 | 0.0864 | 0.0844 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0192 | 0.0864 | 0.1057 |
Entamoeba histolytica | p21-activated kinase | 0.0055 | 0.0065 | 0.0345 |
Brugia malayi | diacylglycerol kinase | 0.0192 | 0.0864 | 0.0999 |
Echinococcus granulosus | cyclin dependent kinase | 0.0051 | 0.0042 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0506 | 0.269 | 0.3291 |
Trichomonas vaginalis | STE family protein kinase | 0.0055 | 0.0065 | 0.0323 |
Giardia lamblia | Kinase, STE STE20 | 0.0055 | 0.0065 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0518 | 0.2762 | 0.2746 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0192 | 0.0864 | 0.0844 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0051 | 0.0042 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0051 | 0.0042 | 0.0177 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1761 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.02 | 0.0907 | 0.1109 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0051 | 0.0042 | 0.0052 |
Trichomonas vaginalis | STE family protein kinase | 0.0055 | 0.0065 | 0.0323 |
Schistosoma mansoni | unc-13 (munc13) | 0.0232 | 0.1097 | 0.1077 |
Echinococcus granulosus | protein kinase c iota type | 0.0466 | 0.2457 | 0.2441 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1761 | 1 | 1 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0232 | 0.1097 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0274 | 0.1337 | 0.1318 |
Brugia malayi | protein kinase C3,putative | 0.02 | 0.0907 | 0.105 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0274 | 0.1337 | 0.1318 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0055 | 0.0065 | 0.0043 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0051 | 0.0042 | 0.002 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0274 | 0.1337 | 0.1318 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0055 | 0.0065 | 0.0043 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.02 | 0.0907 | 0.0887 |
Entamoeba histolytica | protein kinase, putative | 0.0274 | 0.1337 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0051 | 0.0042 | 0.002 |
Brugia malayi | Hr1 repeat family protein | 0.0274 | 0.1337 | 0.156 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.0042 | 0.002 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0192 | 0.0864 | 0.635 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0055 | 0.0065 | 0.0043 |
Trichomonas vaginalis | STE family protein kinase | 0.0055 | 0.0065 | 0.0323 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.02 | 0.0907 | 0.105 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0055 | 0.0065 | 0.0043 |
Entamoeba histolytica | hypothetical protein | 0.0048 | 0.0022 | 0.0023 |
Echinococcus granulosus | protein kinase c eta type | 0.0192 | 0.0864 | 0.0844 |
Brugia malayi | protein kinase C II. | 0.0506 | 0.269 | 0.3166 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0274 | 0.1337 | 0.1318 |
Schistosoma mansoni | unc-13 (munc13) | 0.0232 | 0.1097 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0192 | 0.0864 | 0.0844 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0055 | 0.0065 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0266 | 0.1294 | 0.9677 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0192 | 0.0864 | 0.0844 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.0042 | 0.0154 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0274 | 0.1337 | 0.1636 |
Schistosoma mansoni | serine/threonine protein kinase | 0.02 | 0.0907 | 0.0887 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0051 | 0.0042 | 0.0052 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0274 | 0.1337 | 0.1636 |
Brugia malayi | Protein kinase domain containing protein | 0.0274 | 0.1337 | 0.156 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0192 | 0.0864 | 0.0844 |
Loa Loa (eye worm) | raf kinase | 0.0192 | 0.0864 | 0.1057 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0274 | 0.1337 | 0.1318 |
Schistosoma mansoni | protein kinase C | 0.0232 | 0.1097 | 0.1077 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0192 | 0.0864 | 0.0844 |
Schistosoma mansoni | vav2 | 0.0192 | 0.0864 | 0.0844 |
Brugia malayi | Protein kinase domain containing protein | 0.0274 | 0.1337 | 0.156 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0566 | 0.304 | 0.3582 |
Schistosoma mansoni | serine/threonine protein kinase | 0.02 | 0.0907 | 0.0887 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0274 | 0.1337 | 0.1318 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0274 | 0.1337 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1337 | 0.1636 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.0042 | 0.0154 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0192 | 0.0864 | 0.1057 |
Entamoeba histolytica | protein kinase, putative | 0.0274 | 0.1337 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 0.1337 | 0.1318 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0051 | 0.0042 | 0.0177 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0192 | 0.0864 | 0.0844 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0192 | 0.0864 | 0.0999 |
Echinococcus granulosus | N chimaerin | 0.0192 | 0.0864 | 0.0844 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0506 | 0.269 | 0.2674 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.0042 | 0.002 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0274 | 0.1337 | 0.1636 |
Entamoeba histolytica | protein kinase, putative | 0.0055 | 0.0065 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Entamoeba histolytica | protein kinase, putative | 0.0055 | 0.0065 | 0.0345 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0051 | 0.0042 | 0.0052 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0051 | 0.0042 | 0.5 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0048 | 0.0022 | 0.0027 |
Echinococcus granulosus | protein kinase C gamma type | 0.1569 | 0.888 | 0.8877 |
Brugia malayi | RhoGAP domain containing protein | 0.0192 | 0.0864 | 0.0999 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.1302 | 0.7329 | 0.8966 |
Echinococcus multilocularis | N chimaerin | 0.0192 | 0.0864 | 0.0844 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0055 | 0.0065 | 0.0043 |
Schistosoma mansoni | protein kinase | 0.0055 | 0.0065 | 0.0043 |
Brugia malayi | Protein kinase domain containing protein | 0.0274 | 0.1337 | 0.156 |
Loa Loa (eye worm) | hypothetical protein | 0.1255 | 0.7054 | 0.8629 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.0042 | 0.0154 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0192 | 0.0864 | 0.0844 |
Plasmodium falciparum | protein kinase 5 | 0.0051 | 0.0042 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0051 | 0.0042 | 0.002 |
Brugia malayi | RhoGEF domain containing protein | 0.0192 | 0.0864 | 0.0999 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0192 | 0.0864 | 0.0844 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0274 | 0.1337 | 0.1318 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 0.1337 | 0.1318 |
Schistosoma mansoni | atypical protein kinase C | 0.0466 | 0.2457 | 0.2441 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0274 | 0.1337 | 0.1318 |
Schistosoma mansoni | protein kinase C mu | 0.0192 | 0.0864 | 0.0844 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0055 | 0.0065 | 0.0043 |
Brugia malayi | Protein kinase domain containing protein | 0.0051 | 0.0042 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.1447 | 0.8174 | 1 |
Schistosoma mansoni | protein kinase | 0.0055 | 0.0065 | 0.0043 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0048 | 0.0022 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0274 | 0.1337 | 0.156 |
Brugia malayi | Protein kinase c protein 2 | 0.1495 | 0.8449 | 1 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0192 | 0.0864 | 0.0844 |
Onchocerca volvulus | 0.0232 | 0.1097 | 1 | |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0274 | 0.1337 | 0.1318 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0192 | 0.0864 | 0.1057 |
Echinococcus multilocularis | protein kinase c eta type | 0.0192 | 0.0864 | 0.0844 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0274 | 0.1337 | 1 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0192 | 0.0864 | 0.0844 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0506 | 0.269 | 0.2674 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0192 | 0.0864 | 0.0844 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0051 | 0.0042 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1097 | 0.1342 |
Entamoeba histolytica | protein kinase, putative | 0.0274 | 0.1337 | 1 |
Echinococcus granulosus | unc 13 munc13 | 0.0232 | 0.1097 | 0.1077 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0051 | 0.0042 | 0.5 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0274 | 0.1337 | 0.1318 |
Toxoplasma gondii | AGC kinase | 0.0274 | 0.1337 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0051 | 0.0042 | 0.0024 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0192 | 0.0864 | 0.1057 |
Plasmodium vivax | protein kinase Crk2 | 0.0051 | 0.0042 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Entamoeba histolytica | hypothetical protein | 0.0192 | 0.0864 | 0.6414 |
Brugia malayi | diacylglycerol kinase | 0.0192 | 0.0864 | 0.0999 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0566 | 0.304 | 0.3719 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0232 | 0.1097 | 0.1077 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0192 | 0.0864 | 0.0844 |
Brugia malayi | Pleckstrin Homology Domain | 0.0192 | 0.0864 | 0.0999 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0232 | 0.1097 | 0.1077 |
Brugia malayi | Protein kinase domain | 0.0055 | 0.0065 | 0.005 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0051 | 0.0042 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0051 | 0.0042 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Schistosoma mansoni | protein kinase | 0.0055 | 0.0065 | 0.0043 |
Echinococcus granulosus | myotubularin protein 13 | 0.0192 | 0.0864 | 0.0844 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0051 | 0.0042 | 0.002 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.1255 | 0.7054 | 0.7047 |
Schistosoma mansoni | protein kinase C mu | 0.02 | 0.0907 | 0.0887 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0051 | 0.0042 | 0.002 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0506 | 0.269 | 0.2674 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.02 | 0.0907 | 0.1109 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0022 | 0.0027 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0051 | 0.0042 | 0.002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 0.1337 | 0.1318 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0274 | 0.1337 | 0.1636 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.1255 | 0.7054 | 0.7047 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0192 | 0.0864 | 0.6414 |
Entamoeba histolytica | protein kinase, putative | 0.0055 | 0.0065 | 0.0345 |
Brugia malayi | Protein kinase domain containing protein | 0.02 | 0.0907 | 0.105 |
Brugia malayi | C1-like domain containing protein | 0.02 | 0.0907 | 0.105 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0192 | 0.0864 | 0.0844 |
Schistosoma mansoni | serine/threonine kinase | 0.0274 | 0.1337 | 0.1318 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0051 | 0.0042 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.1337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0274 | 0.1337 | 0.1636 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.1255 | 0.7054 | 0.7047 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.02 | 0.0907 | 0.0887 |
Brugia malayi | Variant SH3 domain containing protein | 0.0192 | 0.0864 | 0.0999 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.1362 | 0.5 |
Brugia malayi | RhoGAP domain containing protein | 0.0192 | 0.0864 | 0.0999 |
Echinococcus granulosus | NDR protein kinase | 0.0274 | 0.1337 | 0.1318 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0864 | 0.1057 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0274 | 0.1337 | 0.1636 |
Entamoeba histolytica | protein kinase, putative | 0.0055 | 0.0065 | 0.0345 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0518 | 0.2762 | 0.2746 |
Echinococcus multilocularis | protein kinase c iota type | 0.0466 | 0.2457 | 0.2441 |
Trichomonas vaginalis | STE family protein kinase | 0.0055 | 0.0065 | 0.0323 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 0.1337 | 0.1318 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.0864 | 0.0844 |
Trichomonas vaginalis | STE family protein kinase | 0.0055 | 0.0065 | 0.0323 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of leucyl-tRNA synthetase (unknown origin) expressed in HEK293 cells assessed as inhibition of leucine-induced mTORC1-mediated S6 kinase phosphorylation pre-treated with compound followed by leucine stimulation for 10 mins by immunoblotting analysis | ChEMBL. | 27209231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.