Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Cryptosporidium parvum | dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 181 aa | 174 aa | 31.6 % |
Cryptosporidium hominis | chain A, crystal structure of Dhfr | Dihydrofolate reductase | 181 aa | 199 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.2894 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0425 | 0.0624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0624 | 0.0624 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0425 | 0.0624 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0425 | 0.0624 | 1 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0425 | 0.0624 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0425 | 0.0624 | 1 |
Schistosoma mansoni | 4-hydroxyphenylpyruvate dioxygenase | 0.0425 | 0.0624 | 1 |
Toxoplasma gondii | glyoxalase I, putative | 0.0425 | 0.0624 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0425 | 0.0624 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.026 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0425 | 0.0624 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0425 | 0.0624 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0425 | 0.0624 | 1 |
Onchocerca volvulus | Putative protein | 0.2894 | 1 | 1 |
Brugia malayi | lactoylglutathione lyase | 0.0425 | 0.0624 | 0.0624 |
Echinococcus granulosus | dihydrofolate reductase | 0.026 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0425 | 0.0624 | 1 |
Schistosoma mansoni | gynecophoral canal protein | 0.0425 | 0.0624 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0425 | 0.0624 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0425 | 0.0624 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0425 | 0.0624 | 1 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0425 | 0.0624 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0425 | 0.0624 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0425 | 0.0624 | 1 |
Toxoplasma gondii | glyoxalase family protein | 0.0425 | 0.0624 | 1 |
Plasmodium vivax | glyoxalase I, putative | 0.0425 | 0.0624 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0425 | 0.0624 | 1 |
Plasmodium vivax | glyoxalase I, putative | 0.0425 | 0.0624 | 1 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0425 | 0.0624 | 1 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.0425 | 0.0624 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0425 | 0.0624 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0425 | 0.0624 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.0006 | 0.5 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0425 | 0.0624 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.026 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.57 | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 11.6 | Selectivity ratio of IC50 for rat liver DHFR to IC50 for Toxoplasma gondii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.69 mM | Inhibition of Mycobacterium avium DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.69 mM | Inhibition of Mycobacterium avium DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 2.69 mM | Inhibition of Toxoplasma gondii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 2.69 mM | Inhibition of Toxoplasma gondii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 31.3 mM | Inhibition of rat liver DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 31.3 mM | Inhibition of rat liver DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 112 mM | Inhibition of Pneumocystis carinii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 112 mM | Inhibition of Pneumocystis carinii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.6 uM | Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (M. avium) | ChEMBL. | 15214795 |
IC50 (binding) | = 0.6 uM | Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (M. avium) | ChEMBL. | 15214795 |
IC50 (binding) | = 2.69 uM | Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (T. gondii) | ChEMBL. | 15214795 |
IC50 (binding) | = 2.69 uM | Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (T. gondii) | ChEMBL. | 15214795 |
IC50 (binding) | = 2.69 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 31.3 uM | Inhibitory concentration against Dihydrofolate reductase from rat liver | ChEMBL. | 15214795 |
IC50 (binding) | = 31.3 uM | Inhibitory concentration against Dihydrofolate reductase from rat liver | ChEMBL. | 15214795 |
IC50 (binding) | = 31.3 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 112 uM | Inhibition of Dihydrofolate reductase from Pneumocystis carinii (P. carinii) | ChEMBL. | 15214795 |
IC50 (binding) | = 112 uM | Inhibition of Dihydrofolate reductase from Pneumocystis carinii (P. carinii) | ChEMBL. | 15214795 |
Ratio IC50 (binding) | = 0.28 | Selectivity ratio of IC50 for rat liver DHFR to IC50 for Pneumocystis carinii DHFR | ChEMBL. | 17552508 |
Ratio IC50 (binding) | = 45.4 | Selectivity ratio of IC50 for rat liver DHFR to IC50 for Mycobacterium avium DHFR | ChEMBL. | 17552508 |
Selectivity ratio (binding) | = 0.28 | Selectivity ratio [(IC50 rlDHFR)/(IC50 pcDHFR) | ChEMBL. | 15214795 |
Selectivity ratio (binding) | = 11.6 | Selectivity ratio (IC50rlDHFR)/(IC50 tgDHFR) | ChEMBL. | 15214795 |
Selectivity ratio (binding) | = 56.4 | Selectivity ratio (IC50 rlDHFR)/(IC50 maDHFR) | ChEMBL. | 15214795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.