Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | References | |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0645 | 0.9691 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.1302 | 0.1343 |
Brugia malayi | Matrixin family protein | 0.0293 | 0.2827 | 0.2917 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.1302 | 0.1343 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.1302 | 0.1343 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0645 | 0.9691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0631 | 0.9415 | 0.9715 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0147 | 0 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0147 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.044 | 0.5697 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.1302 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.1302 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0268 | 0.2356 | 0.2431 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.1302 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0268 | 0.2356 | 0.1978 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.1302 | 0.1343 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.1302 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.1302 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0147 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0293 | 0.2827 | 0.2917 |
Brugia malayi | Hemopexin family protein | 0.0172 | 0.0471 | 0.0486 |
Onchocerca volvulus | Matrilysin homolog | 0.0268 | 0.2356 | 0.1978 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.1302 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.044 | 0.5697 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.92 | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 7.18 | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 15 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase II | ChEMBL. | 11020282 |
Ki (binding) | = 15 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase II | ChEMBL. | 11020282 |
Ki (binding) | = 20 nM | Inhibitory activity against bCA -IV | ChEMBL. | 11020282 |
Ki (binding) | = 20 nM | Inhibitory activity against bCA -IV | ChEMBL. | 11020282 |
Ki (binding) | = 29 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase I | ChEMBL. | 11020282 |
Ki (binding) | = 29 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase I | ChEMBL. | 11020282 |
Ki (binding) | = 66 nM | Inhibitory activity against Matrix metalloproteinase-2 | ChEMBL. | 11020282 |
Ki (binding) | = 66 nM | Inhibitory activity against Matrix metalloproteinase-2 | ChEMBL. | 11020282 |
Ki (binding) | = 78 nM | Inhibitory activity against Clostridium histolyticum collagenase (ChC) was determined | ChEMBL. | 11020282 |
Ki (binding) | = 78 nM | Inhibitory activity against Clostridium histolyticum collagenase (ChC) was determined | ChEMBL. | 11020282 |
Ki (binding) | = 111 nM | Inhibitory activity against Matrix metalloproteinase-8 | ChEMBL. | 11020282 |
Ki (binding) | = 111 nM | Inhibitory activity against Matrix metalloproteinase-8 | ChEMBL. | 11020282 |
Ki (binding) | = 120 nM | Inhibitory activity against Matrix metalloproteinase-9 | ChEMBL. | 11020282 |
Ki (binding) | = 120 nM | Inhibitory activity against Matrix metalloproteinase-9 | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against matrix metalloproteinase-1 | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against matrix metalloproteinase-1 | ChEMBL. | 11020282 |
log(1/Ki) (binding) | = 6.92 | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17275314 |
log(1/Ki) (binding) | = 7.18 | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17275314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.