Detailed information for compound 214359

Basic information

Technical information
  • TDR Targets ID: 214359
  • Name: [2-tetradecanoyloxy-5-[2-(2,4,6-trimethylpyri din-1-ium-1-yl)ethyl]phenyl] tetradecanoate h exafluorophosphate
  • MW: 824.011 | Formula: C44H72F6NO4P
  • H donors: 0 H acceptors: 2 LogP: 19.25 Rotable bonds: 31
    Rule of 5 violations (Lipinski): 2
  • SMILES: F[P-](F)(F)(F)(F)F.CCCCCCCCCCCCCC(=O)Oc1cc(ccc1OC(=O)CCCCCCCCCCCCC)CC[n+]1c(C)cc(cc1C)C
  • InChi: 1S/C44H72NO4.F6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-43(46)48-41-31-30-40(32-33-45-38(4)34-37(3)35-39(45)5)36-42(41)49-44(47)29-27-25-23-21-19-17-15-13-11-9-7-2;1-7(2,3,4,5)6/h30-31,34-36H,6-29,32-33H2,1-5H3;/q+1;-1
  • InChiKey: FFXFLOFAXILRSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tetradecanoic acid [2-(1-oxotetradecoxy)-5-[2-(2,4,6-trimethyl-1-pyridin-1-iumyl)ethyl]phenyl] ester hexafluorophosphate
  • myristic acid [2-tetradecanoyloxy-5-[2-(2,4,6-trimethylpyridin-1-ium-1-yl)ethyl]phenyl] ester hexafluorophosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0102 0.018 0.0142
Brugia malayi Cell death protein 3 precursor 0.1019 0.5495 0.6841
Echinococcus granulosus glycine receptor subunit beta 0.0412 0.1976 0.2462
Brugia malayi Cation transporter family protein 0.0306 0.1363 0.1689
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Echinococcus multilocularis caspase 8 0.0306 0.1365 0.1692
Onchocerca volvulus 0.0202 0.0762 0.1222
Echinococcus multilocularis geminin 0.0195 0.0719 0.0885
Schistosoma mansoni histamine h1 receptor 0.0202 0.0762 0.0939
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.078 0.4108 0.7843
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0412 0.1976 0.2453
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0412 0.1976 0.2453
Loa Loa (eye worm) hypothetical protein 0.0478 0.236 0.2355
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1353 0.7425 0.9248
Onchocerca volvulus 0.0202 0.0762 0.1222
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0329 0.1498 0.2859
Brugia malayi G-protein coupled receptor 0.0202 0.0762 0.0939
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0306 0.1363 0.1698
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Onchocerca volvulus 0.0202 0.0762 0.1222
Trichomonas vaginalis conserved hypothetical protein 0.1519 0.8385 1
Echinococcus granulosus tm gpcr rhodopsin 0.0202 0.0762 0.0949
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.032 0.1447 0.1794
Loa Loa (eye worm) hypothetical protein 0.0412 0.1976 0.1971
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus multilocularis apoptotic protease activating factor 1 0.0713 0.3721 0.463
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0199 0.0741 0.0924
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Echinococcus granulosus voltage dependent calcium channel 0.0199 0.0741 0.0924
Onchocerca volvulus 0.0202 0.0762 0.1222
Onchocerca volvulus 0.0713 0.3721 0.671
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0612 0.3134 0.3129
Echinococcus multilocularis serotonin receptor 0.0473 0.233 0.2894
Echinococcus granulosus biogenic amine 5HT receptor 0.0473 0.233 0.2902
Giardia lamblia Fructose-bisphosphate aldolase 0.0674 0.3493 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0202 0.0762 0.0939
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Echinococcus granulosus carbonic anhydrase 0.0612 0.3134 0.3904
Loa Loa (eye worm) ACC-1 protein 0.0306 0.1363 0.1358
Echinococcus granulosus serotonin receptor 0.0202 0.0762 0.0949
Loa Loa (eye worm) hypothetical protein 0.0199 0.0741 0.0735
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0202 0.0762 0.0939
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0306 0.1363 0.1689
Brugia malayi hypothetical protein 0.0136 0.0378 0.046
Entamoeba histolytica hypothetical protein 0.017 0.0577 0.0722
Onchocerca volvulus 0.0388 0.1837 0.3216
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Schistosoma mansoni voltage-gated potassium channel 0.0349 0.1612 0.1999
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0202 0.0762 0.0949
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0306 0.1365 0.1692
Mycobacterium ulcerans carbonic anhydrase 0.1519 0.8385 1
Mycobacterium ulcerans carbonic anhydrase 0.1451 0.7996 0.9525
Echinococcus multilocularis neuropeptides capa receptor 0.0202 0.0762 0.0939
Onchocerca volvulus 0.0202 0.0762 0.1222
Loa Loa (eye worm) hypothetical protein 0.0276 0.119 0.1184
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.1363 0.1689
Echinococcus multilocularis nAChR subunit 0.017 0.0577 0.0709
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus granulosus caspase 2 0.1019 0.5495 0.6845
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0199 0.0741 0.0924
Trypanosoma cruzi metacaspase, putative 0.0306 0.1365 0.165
Schistosoma mansoni neuropeptide receptor 0.0202 0.0762 0.0939
Echinococcus multilocularis G protein coupled receptor 139 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0732 0.3832 0.4773
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Echinococcus granulosus carbonic anhydrase 0.0612 0.3134 0.3904
Loa Loa (eye worm) G-protein coupled receptor 0.0202 0.0762 0.0756
Echinococcus multilocularis g protein coupled receptor 0.0202 0.0762 0.0939
Echinococcus multilocularis transmembrane protease serine 3 0.0102 0.018 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0202 0.0762 0.0939
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0306 0.1363 0.1689
Brugia malayi Trypsin family protein 0.0102 0.018 0.0213
Loa Loa (eye worm) G-protein coupled receptor 0.0202 0.0762 0.0756
Onchocerca volvulus 0.0202 0.0762 0.1222
Onchocerca volvulus 0.0102 0.018 0.0142
Echinococcus granulosus nAChR subunit 0.017 0.0577 0.0719
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0329 0.1498 0.1606
Echinococcus granulosus glycine receptor subunit alpha 1 0.0412 0.1976 0.2462
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0388 0.1837 0.228
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.1363 0.1689
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Brugia malayi Carboxylesterase family protein 0.0131 0.0352 0.0427
Onchocerca volvulus 0.0202 0.0762 0.1222
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0289 0.1267 0.1501
Treponema pallidum fructose-bisphosphate aldolase 0.0674 0.3493 0.5
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0088 0.0104 0.0118
Onchocerca volvulus 0.0202 0.0762 0.1222
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0072 0.0009 0.0011
Onchocerca volvulus Nischarin homolog 0.0458 0.2245 0.3972
Onchocerca volvulus Putative sulfate transporter 0.0205 0.0777 0.125
Echinococcus multilocularis neuropeptide FF receptor 2 0.0202 0.0762 0.0939
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0242 0.0991 0.1234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0102 0.018 0.0224
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Trypanosoma brucei C-8 sterol isomerase, putative 0.0819 0.4332 0.5368
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0306 0.1363 0.1689
Echinococcus granulosus tachykinin peptides receptor 99D 0.0202 0.0762 0.0949
Onchocerca volvulus 0.0202 0.0762 0.1222
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.01 0.0174 0.0205
Echinococcus granulosus acetylcholinesterase 0.0131 0.0352 0.0438
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Schistosoma mansoni alpha-1 adrenergic receptor 0.0202 0.0762 0.0939
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0136 0.0378 0.0471
Trypanosoma brucei metacaspase 5, putative 0.0306 0.1365 0.165
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1365 0.1619
Echinococcus multilocularis acetylcholinesterase 0.0131 0.0352 0.0427
Loa Loa (eye worm) melatonin receptor type 1A 0.0202 0.0762 0.0756
Schistosoma mansoni carbonic anhydrase 0.1451 0.7996 0.996
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Echinococcus multilocularis enteropeptidase 0.0102 0.018 0.0213
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0072 0.0009 0.0011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0612 0.3134 0.3897
Onchocerca volvulus 0.0306 0.1363 0.2337
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0732 0.3832 0.4767
Brugia malayi Serotonin/octopamine receptor family protein 7 0.086 0.4569 0.5687
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0084 0.0077 0.007
Schistosoma mansoni hypothetical protein 0.0102 0.018 0.0213
Echinococcus multilocularis voltage gated potassium channel 0.01 0.0174 0.0206
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.1363 0.1689
Onchocerca volvulus 0.0202 0.0762 0.1222
Schistosoma mansoni nAChR subunit 0.0306 0.1363 0.1689
Echinococcus granulosus sodium:myo inositol cotransporter 0.0088 0.0104 0.0129
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0412 0.1976 0.2462
Echinococcus multilocularis glycoprotein Antigen 5 0.0102 0.018 0.0213
Brugia malayi hypothetical protein 0.0713 0.3721 0.4629
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0378 0.046
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0202 0.0762 0.0939
Onchocerca volvulus 0.0136 0.0378 0.0509
Loa Loa (eye worm) hypothetical protein 0.0088 0.0104 0.0097
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0306 0.1363 0.1689
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0202 0.0762 0.0939
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.017 0.0577 0.0709
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0202 0.0762 0.0939
Plasmodium vivax hypothetical protein, conserved 0.0306 0.1365 0.5
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0102 0.018 0.0224
Echinococcus multilocularis voltage dependent calcium channel 0.0199 0.0741 0.0914
Brugia malayi Carboxylesterase family protein 0.0131 0.0352 0.0427
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0202 0.0762 0.0939
Echinococcus granulosus neuropeptide Y receptor 0.0202 0.0762 0.0949
Brugia malayi hypothetical protein 0.0458 0.2245 0.2789
Echinococcus multilocularis high affinity choline transporter 1 0.0801 0.4232 0.5266
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.1363 0.1689
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0306 0.1363 0.1689
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus multilocularis serotonin receptor 0.0473 0.233 0.2894
Loa Loa (eye worm) hypothetical protein 0.0306 0.1365 0.136
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0202 0.0762 0.0939
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0202 0.0762 0.0939
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Echinococcus granulosus g protein coupled receptor 0.0202 0.0762 0.0949
Echinococcus granulosus GA binding protein alpha chain 0.0084 0.0077 0.0096
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus granulosus somatostatin receptor 0.0202 0.0762 0.0949
Brugia malayi hypothetical protein 0.0102 0.018 0.0213
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.0577 0.0709
Echinococcus granulosus glutamate NMDA receptor subunit 0.0139 0.0398 0.0496
Echinococcus granulosus enteropeptidase 0.0102 0.018 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.1519 0.8385 1
Brugia malayi ORL1-like opioid receptor 0.0202 0.0762 0.0939
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0199 0.0741 0.0914
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0242 0.0991 0.1224
Schistosoma mansoni acetylcholine receptor-related 0.0136 0.0378 0.046
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0202 0.0762 0.0756
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.032 0.1447 0.1793
Echinococcus multilocularis voltage dependent calcium channel 0.0199 0.0741 0.0914
Echinococcus multilocularis g protein coupled receptor 0.0202 0.0762 0.0939
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0306 0.1363 0.1689
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0072 0.0009 0.0003
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.1363 0.1689
Schistosoma mansoni hypothetical protein 0.0202 0.0762 0.0939
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Schistosoma mansoni carbonic anhydrase-related 0.0612 0.3134 0.3897
Loa Loa (eye worm) hypothetical protein 0.017 0.0577 0.0571
Schistosoma mansoni hypothetical protein 0.0202 0.0762 0.0939
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0412 0.1976 0.2453
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0199 0.0741 0.0914
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0612 0.3134 0.3897
Brugia malayi Tachykinin-like peptides receptor 99D 0.0202 0.0762 0.0939
Schistosoma mansoni hypothetical protein 0.0195 0.0719 0.0885
Echinococcus multilocularis G-protein coupled receptor, putative 0.0202 0.0762 0.0939
Schistosoma mansoni sodium/solute symporter 0.0088 0.0104 0.0118
Echinococcus granulosus Mastin 0.0102 0.018 0.0224
Schistosoma mansoni carbonic anhydrase-related 0.0612 0.3134 0.3897
Schistosoma mansoni biogenic amine (5HT) receptor 0.0202 0.0762 0.0939
Schistosoma mansoni biogenic amine receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0378 0.046
Echinococcus multilocularis GA binding protein alpha chain 0.0084 0.0077 0.0085
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Schistosoma mansoni caspase-7 (C14 family) 0.1019 0.5495 0.6841
Echinococcus multilocularis caspase 0.0306 0.1365 0.1692
Loa Loa (eye worm) acetylcholinesterase 1 0.0131 0.0352 0.0345
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1457 0.8028 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0072 0.0009 0.0011
Schistosoma mansoni nAChR subunit 0.0306 0.1363 0.1689
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1457 0.8028 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0202 0.0762 0.0939
Trypanosoma cruzi metacaspase 5, putative 0.0306 0.1365 0.165
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0202 0.0762 0.0949
Onchocerca volvulus 0.0202 0.0762 0.1222
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1457 0.8028 1
Echinococcus granulosus neuropeptides capa receptor 0.0202 0.0762 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1365 0.1619
Echinococcus granulosus hypothetical protein 0.1 0.5384 0.6706
Brugia malayi Dopamine receptor protein 2 0.0202 0.0762 0.0939
Schistosoma mansoni carbonic anhydrase-related 0.0612 0.3134 0.3897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Onchocerca volvulus Neuropeptide F receptor homolog 0.0202 0.0762 0.1222
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0306 0.1363 0.1689
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0139 0.0398 0.0485
Echinococcus multilocularis carbonic anhydrase 0.0612 0.3134 0.3897
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0975 0.5238 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0202 0.0762 0.0949
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0088 0.0104 0.0118
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Onchocerca volvulus 0.0102 0.018 0.0142
Echinococcus granulosus hyperpolarization activated cyclic 0.0072 0.0009 0.0011
Brugia malayi RE15519p 0.0202 0.0762 0.0939
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0306 0.1365 0.4164
Echinococcus granulosus alpha 1A adrenergic receptor 0.0202 0.0762 0.0949
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0306 0.1365 0.1701
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0412 0.1976 0.2453
Schistosoma mansoni hypothetical protein 0.0713 0.3721 0.4629
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0674 0.3493 0.4369
Loa Loa (eye worm) hypothetical protein 0.0102 0.018 0.0174
Leishmania major metacaspase, putative 0.0306 0.1365 0.165
Brugia malayi G protein-coupled receptor 0.0202 0.0762 0.0939
Brugia malayi Sodium:solute symporter family protein 0.0088 0.0104 0.0118
Echinococcus granulosus rhodopsin orphan GPCR 0.0202 0.0762 0.0949
Schistosoma mansoni glutamate receptor NMDA 0.0139 0.0398 0.0485
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0674 0.3493 0.4369
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0306 0.1363 0.1689
Brugia malayi Trypsin family protein 0.0102 0.018 0.0213
Loa Loa (eye worm) LGC-31 protein 0.0306 0.1363 0.1358
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0102 0.018 0.0174
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0306 0.1363 0.1698
Onchocerca volvulus 0.0202 0.0762 0.1222
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0412 0.1976 0.1971
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0202 0.0762 0.0756
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0136 0.0378 0.046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Echinococcus multilocularis sex peptide receptor 0.0202 0.0762 0.0939
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0136 0.0378 0.046
Leishmania major carbonic anhydrase family protein, putative 0.1451 0.7996 0.996
Echinococcus granulosus neuropeptide receptor A26 0.0202 0.0762 0.0949
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Brugia malayi GH02984p 0.0801 0.4232 0.5266
Onchocerca volvulus 0.0306 0.1363 0.2337
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.1363 0.1689
Echinococcus granulosus rhodopsin orphan GPCR 0.0202 0.0762 0.0949
Loa Loa (eye worm) hypothetical protein 0.0801 0.4232 0.4228
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Onchocerca volvulus 0.0202 0.0762 0.1222
Loa Loa (eye worm) hypothetical protein 0.0388 0.1837 0.1832
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0306 0.1363 0.1358
Echinococcus multilocularis neuropeptide receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0202 0.0762 0.0939
Echinococcus granulosus carboxylesterase 5A 0.0131 0.0352 0.0438
Leishmania major carbonic anhydrase-like protein 0.1457 0.8028 1
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0908 0.4849 0.9256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Brugia malayi G-protein coupled receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0306 0.1363 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1365 0.1619
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0388 0.1837 0.1832
Loa Loa (eye worm) hypothetical protein 0.0131 0.0352 0.0345
Leishmania major C-8 sterol isomerase-like protein 0.0819 0.4332 0.5368
Schistosoma mansoni opsin-like receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0819 0.4332 0.4328
Loa Loa (eye worm) hypothetical protein 0.0102 0.018 0.0174
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus granulosus rhodopsin orphan GPCR 0.0202 0.0762 0.0949
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Brugia malayi hypothetical protein 0.0136 0.0378 0.046
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0306 0.1365 0.4164
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus granulosus 7TM GPCR rhodopsin 0.0202 0.0762 0.0949
Schistosoma mansoni amine GPCR 0.0202 0.0762 0.0939
Schistosoma mansoni neuropeptide receptor 0.0202 0.0762 0.0939
Onchocerca volvulus Putative nachr subunit 0.0306 0.1363 0.2337
Echinococcus multilocularis carbonic anhydrase II 0.1457 0.8028 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0306 0.1363 0.1698
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0612 0.3134 0.3897
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.1363 0.1689
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Echinococcus granulosus 7tm_1 domain containing protein 0.0202 0.0762 0.0949
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Onchocerca volvulus Cell death protein 3 homolog 0.1019 0.5495 1
Loa Loa (eye worm) hypothetical protein 0.1019 0.5495 0.5492
Trypanosoma cruzi metacaspase, putative 0.0306 0.1365 0.165
Echinococcus multilocularis glycine receptor subunit beta 0.0412 0.1976 0.2453
Echinococcus granulosus rhodopsin orphan GPCR 0.0202 0.0762 0.0949
Loa Loa (eye worm) calcium channel 0.0199 0.0741 0.0735
Echinococcus multilocularis g protein coupled receptor 0.0202 0.0762 0.0939
Echinococcus granulosus voltage gated potassium channel 0.01 0.0174 0.0216
Echinococcus granulosus neuropeptide receptor 0.0202 0.0762 0.0949
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0329 0.1498 0.0763
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0306 0.1363 0.1689
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0072 0.0009 0.0011
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0306 0.1363 0.1698
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0102 0.018 0.0213
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0306 0.1365 0.4164
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Brugia malayi larval opioid receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Brugia malayi follicle stimulating hormone receptor 0.0202 0.0762 0.0939
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Entamoeba histolytica carbonic anhydrase, putative 0.1451 0.7996 1
Schistosoma mansoni ets-related 0.0254 0.1064 0.1316
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0102 0.018 0.0213
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0199 0.0741 0.0924
Schistosoma mansoni biogenic amine receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0102 0.018 0.0174
Echinococcus granulosus apoptotic protease activating factor 1 0.0713 0.3721 0.4636
Loa Loa (eye worm) acetylcholine receptor protein 0.0136 0.0378 0.0372
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0072 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0072 0.0009 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0174 0.0205
Brugia malayi hypothetical protein 0.0674 0.3495 0.4348
Echinococcus granulosus glycoprotein Antigen 5 0.0102 0.018 0.0224
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Echinococcus multilocularis nAChR subunit 0.0306 0.1363 0.1689
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0202 0.0762 0.0939
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0202 0.0762 0.0939
Schistosoma mansoni growth hormone secretagogue receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0473 0.233 0.2325
Echinococcus multilocularis g-protein coupled receptor 0.0202 0.0762 0.0939
Schistosoma mansoni nAChR subunit 0.0306 0.1363 0.1689
Echinococcus multilocularis glycine receptor subunit beta 0.0412 0.1976 0.2453
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Schistosoma mansoni opsin-like receptor 0.0202 0.0762 0.0939
Onchocerca volvulus 0.017 0.0577 0.0879
Plasmodium vivax metacaspase 1, putative 0.0306 0.1365 0.5
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Onchocerca volvulus 0.0136 0.0378 0.0509
Echinococcus granulosus glycine receptor subunit beta 0.0412 0.1976 0.2462
Loa Loa (eye worm) hypothetical protein 0.0473 0.233 0.2325
Echinococcus multilocularis neuropeptide receptor 0.0202 0.0762 0.0939
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Schistosoma mansoni amine GPCR 0.0202 0.0762 0.0939
Echinococcus multilocularis carbonic anhydrase 0.0612 0.3134 0.3897
Echinococcus granulosus high affinity choline transporter 1 0.0801 0.4232 0.5271
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0202 0.0762 0.0949
Onchocerca volvulus 0.0306 0.1363 0.2337
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0202 0.0762 0.0756
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0202 0.0762 0.0939
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0819 0.4332 0.5391
Loa Loa (eye worm) hypothetical protein 0.0612 0.3134 0.3129
Onchocerca volvulus 0.0102 0.018 0.0142
Echinococcus granulosus nAChR subunit 0.0306 0.1363 0.1698
Brugia malayi Cation transporter family protein 0.0412 0.1976 0.2453
Brugia malayi GnHR receptor homolog 0.0202 0.0762 0.0939
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0242 0.0991 0.1224
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Schistosoma mansoni biogenic amine (5HT) receptor 0.0473 0.233 0.2894
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.017 0.0577 0.0709
Brugia malayi Cation transporter family protein 0.0388 0.1837 0.228
Trypanosoma cruzi metacaspase 5, putative 0.0306 0.1365 0.165
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0072 0.0009 0.0003
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0306 0.1363 0.1698
Echinococcus granulosus tm gpcr rhodopsin 0.1353 0.7425 0.9248
Loa Loa (eye worm) hypothetical protein 0.0713 0.3721 0.3717
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Echinococcus granulosus g protein coupled receptor 0.0202 0.0762 0.0949
Schistosoma mansoni gabp alpha 0.0084 0.0077 0.0085
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0236 0.0961 0.1835
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0202 0.0762 0.0756
Echinococcus granulosus neuropeptide Y receptor 0.0202 0.0762 0.0949
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus multilocularis neuropeptide receptor A26 0.0202 0.0762 0.0939
Schistosoma mansoni myosin xvIII 0.0202 0.0762 0.0939
Schistosoma mansoni nAChR subunit 0.0306 0.1363 0.1689
Schistosoma mansoni hypothetical protein 0.0195 0.0719 0.0885
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.007 0 0.5
Onchocerca volvulus 0.0102 0.018 0.0142
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0306 0.1363 0.1689
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0202 0.0762 0.0939
Brugia malayi Trypsin family protein 0.0102 0.018 0.0213
Brugia malayi putative neuropeptide receptor NPR1 0.0202 0.0762 0.0939
Schistosoma mansoni neuropeptide F-like receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) GABA receptor subunit 0.0276 0.119 0.1184
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0202 0.0762 0.0939
Brugia malayi Ets-domain containing protein 0.0084 0.0077 0.0085
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.017 0.0577 0.0709
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0202 0.0762 0.0939
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0199 0.0741 0.0913
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1457 0.8028 0.8027
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0202 0.0762 0.0939
Onchocerca volvulus 0.0202 0.0762 0.1222
Schistosoma mansoni amine GPCR 0.0202 0.0762 0.0939
Loa Loa (eye worm) fli-1 protein 0.0254 0.1064 0.1059
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0199 0.0741 0.0914
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.032 0.1447 0.1441
Loa Loa (eye worm) carbonic anhydrase 3 0.1457 0.8028 0.8027
Loa Loa (eye worm) hypothetical protein 0.086 0.4569 0.4566
Echinococcus granulosus G protein coupled receptor 139 0.0202 0.0762 0.0949
Loa Loa (eye worm) hypothetical protein 0.017 0.0577 0.0571
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0306 0.1363 0.1689
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0289 0.1267 0.1501
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0199 0.0741 0.0913
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus multilocularis somatostatin receptor 0.0202 0.0762 0.0939
Echinococcus multilocularis fmrfamide receptor 0.0202 0.0762 0.0939
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.1363 0.1689
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0079 0.0049 0.005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.0577 0.0709
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0819 0.4332 0.5368
Schistosoma mansoni adenoreceptor 0.0202 0.0762 0.0939
Brugia malayi neuropeptide F receptor 0.0202 0.0762 0.0939
Brugia malayi Ets-domain containing protein 0.0084 0.0077 0.0085
Echinococcus granulosus orexin receptor type 2 0.0202 0.0762 0.0949
Echinococcus granulosus sex peptide receptor 0.0202 0.0762 0.0949
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0306 0.1363 0.1698
Echinococcus multilocularis carboxylesterase 5A 0.0131 0.0352 0.0427
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0202 0.0762 0.0939
Schistosoma mansoni nAChR subunit 0.0136 0.0378 0.046
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0102 0.018 0.0213
Loa Loa (eye worm) hypothetical protein 0.0458 0.2245 0.224
Loa Loa (eye worm) hypothetical protein 0.086 0.4569 0.4566
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Schistosoma mansoni inositol transporter 0.0088 0.0104 0.0118
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0612 0.3134 0.3897
Echinococcus multilocularis orexin receptor type 2 0.0202 0.0762 0.0939
Echinococcus granulosus rhodopsin orphan GPCR 0.0202 0.0762 0.0949
Brugia malayi Trypsin-like protease protein 5 0.0102 0.018 0.0213
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Echinococcus multilocularis neuropeptides capa receptor 0.0202 0.0762 0.0939
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0079 0.0049 0.0061
Echinococcus multilocularis nischarin 0.0469 0.2309 0.2868
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0242 0.0991 0.0985
Brugia malayi G protein-coupled receptor F59B2.13 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.017 0.0577 0.0571
Brugia malayi hypothetical protein 0.0136 0.0378 0.046
Loa Loa (eye worm) hypothetical protein 0.0674 0.3495 0.3491
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0306 0.1363 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1365 0.1619
Echinococcus multilocularis allatostatin A receptor 0.0202 0.0762 0.0939
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Loa Loa (eye worm) hypothetical protein 0.017 0.0577 0.0571
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0306 0.1363 0.1358
Loa Loa (eye worm) ACC-1 protein 0.0306 0.1363 0.1358
Trypanosoma cruzi metacaspase, putative 0.0306 0.1365 0.165
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Plasmodium falciparum carbonic anhydrase 0.0612 0.3134 1
Echinococcus granulosus nischarin 0.0469 0.2309 0.2876
Brugia malayi Melatonin receptor type 1A 0.0202 0.0762 0.0939
Loa Loa (eye worm) TYRA-2 protein 0.0202 0.0762 0.0756
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.007 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1365 0.1619
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Onchocerca volvulus 0.0388 0.1837 0.3216
Echinococcus granulosus neuropeptide s receptor 0.0202 0.0762 0.0949
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0202 0.0762 0.0939
Echinococcus granulosus neuropeptide FF receptor 2 0.0202 0.0762 0.0949
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0199 0.0741 0.0913
Schistosoma mansoni multidrug resistance protein 0.0079 0.0049 0.005
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0136 0.0378 0.0372
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0732 0.3832 0.4767
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0202 0.0762 0.0939
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0202 0.0762 0.0939
Echinococcus multilocularis neuropeptide s receptor 0.0202 0.0762 0.0939
Echinococcus granulosus rhodopsin orphan GPCR 0.0202 0.0762 0.0949
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0088 0.0104 0.0129
Loa Loa (eye worm) hypothetical protein 0.0102 0.018 0.0174
Echinococcus granulosus sodium:glucose cotransporter 0.0088 0.0104 0.0129
Echinococcus granulosus sodium:glucose cotransporter 2 0.0088 0.0104 0.0129
Echinococcus granulosus caspase 8 0.0306 0.1365 0.1701
Brugia malayi putative neuropeptide receptor 0.0202 0.0762 0.0939
Echinococcus granulosus neuropeptide receptor 0.0202 0.0762 0.0949
Schistosoma mansoni neuropeptide F-like receptor 0.0202 0.0762 0.0939
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0306 0.1363 0.1689
Echinococcus granulosus allatostatin A receptor 0.0202 0.0762 0.0949
Onchocerca volvulus 0.0202 0.0762 0.1222
Echinococcus multilocularis carbonic anhydrase 0.0612 0.3134 0.3897
Loa Loa (eye worm) hypothetical protein 0.0279 0.121 0.1205
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.017 0.0577 0.0571
Loa Loa (eye worm) hypothetical protein 0.0102 0.018 0.0174
Echinococcus multilocularis conserved hypothetical protein 0.0798 0.4214 0.5243
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0131 0.0352 0.0427
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0412 0.1976 0.2453
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0199 0.0741 0.0914
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0412 0.1976 0.2453
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1457 0.8028 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.032 0.1447 0.1803
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0174 0.0205
Schistosoma mansoni caspase-3 (C14 family) 0.0306 0.1365 0.1691
Echinococcus granulosus peptide allatostatin:somatostatin 0.0202 0.0762 0.0949
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0306 0.1365 0.1691
Echinococcus multilocularis dro:myosuppressin receptor 0.0202 0.0762 0.0939
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Schistosoma mansoni neurotransmitter gated ion channel 0.0136 0.0378 0.046
Loa Loa (eye worm) hypothetical protein 0.01 0.0174 0.0167
Brugia malayi excitatory GABA receptor EXP-1A 0.0306 0.1363 0.1689
Echinococcus granulosus glycine receptor subunit alpha 1 0.0412 0.1976 0.2462
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0612 0.3134 0.3897
Schistosoma mansoni hypothetical protein 0.0202 0.0762 0.0939
Loa Loa (eye worm) neuropeptide F receptor 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.0252 0.1051 0.1046
Brugia malayi Dopamine receptor protein 1 0.0202 0.0762 0.0939
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0276 0.119 0.1473
Schistosoma mansoni voltage-gated potassium channel 0.0349 0.1612 0.1999
Schistosoma mansoni neuropeptide receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Loa Loa (eye worm) hypothetical protein 0.0612 0.3134 0.3129
Schistosoma mansoni hypothetical protein 0.0612 0.3134 0.3897
Schistosoma mansoni neurotransmitter gated ion channel 0.017 0.0577 0.0709
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0202 0.0762 0.0939
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Onchocerca volvulus 0.0102 0.018 0.0142
Schistosoma mansoni amine GPCR 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Brugia malayi sulfakinin receptor protein 0.0674 0.3495 0.4348
Schistosoma mansoni neurotransmitter gated ion channel 0.0136 0.0378 0.046
Schistosoma mansoni neuropeptide receptor 0.0202 0.0762 0.0939
Schistosoma mansoni nAChR subunit 0.0306 0.1363 0.1689
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Schistosoma mansoni neuropeptide f receptor 76f 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Schistosoma mansoni hypothetical protein 0.0202 0.0762 0.0939
Echinococcus granulosus acetylcholinesterase 0.0131 0.0352 0.0438
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.1363 0.1689
Brugia malayi Dopamine receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Schistosoma mansoni biogenic amine receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Trypanosoma brucei metacaspase MCA3 0.0306 0.1365 0.165
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Echinococcus granulosus g-protein coupled receptor 0.0202 0.0762 0.0949
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Echinococcus multilocularis fmrfamide receptor 0.0202 0.0762 0.0939
Schistosoma mansoni cercarial elastase (S01 family) 0.0102 0.018 0.0213
Loa Loa (eye worm) trypsin family protein 0.0102 0.018 0.0174
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) carboxylesterase 0.0131 0.0352 0.0345
Schistosoma mansoni nAChR subunit 0.0306 0.1363 0.1689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Trypanosoma brucei metacaspase 0.0306 0.1365 0.165
Echinococcus granulosus carbonic anhydrase 0.0612 0.3134 0.3904
Trypanosoma brucei Metacaspase-4 0.0306 0.1365 0.165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0674 0.3493 0.4159
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.01 0.0174 0.0206
Schistosoma mansoni inositol transporter 0.0088 0.0104 0.0118
Echinococcus multilocularis solute carrier family 5 0.0088 0.0104 0.0118
Echinococcus multilocularis Mastin 0.0102 0.018 0.0213
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0088 0.0104 0.0118
Loa Loa (eye worm) neuropeptide F receptor 0.0202 0.0762 0.0756
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1365 0.1619
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0306 0.1363 0.1698
Brugia malayi Serotonin receptor 0.0202 0.0762 0.0939
Brugia malayi hypothetical protein 0.0202 0.0762 0.0939
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0378 0.046
Brugia malayi neuropeptide F receptor 0.0202 0.0762 0.0939
Onchocerca volvulus 0.0388 0.1837 0.3216
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0306 0.1363 0.1689
Echinococcus multilocularis neuropeptide Y receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0102 0.018 0.0174
Toxoplasma gondii hypothetical protein 0.0612 0.3134 1
Schistosoma mansoni hypothetical protein 0.0102 0.018 0.0213
Schistosoma mansoni high-affinity choline transporter 0.0801 0.4232 0.5266
Trypanosoma cruzi metacaspase, putative 0.0306 0.1365 0.165
Loa Loa (eye worm) hypothetical protein 0.0136 0.0378 0.0372
Brugia malayi hypothetical protein 0.0136 0.0378 0.046
Loa Loa (eye worm) hypothetical protein 0.0306 0.1363 0.1358
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Loa Loa (eye worm) hypothetical protein 0.017 0.0577 0.0571
Loa Loa (eye worm) hypothetical protein 0.017 0.0577 0.0571
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0202 0.0762 0.0939
Brugia malayi AKH receptor 0.0202 0.0762 0.0939
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0306 0.1363 0.1689
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1451 0.7996 1
Echinococcus granulosus fmrfamide receptor 0.0202 0.0762 0.0949
Echinococcus multilocularis acetylcholinesterase 0.0131 0.0352 0.0427
Schistosoma mansoni opsin-like receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0131 0.0352 0.0345
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0202 0.0762 0.0939
Echinococcus multilocularis rhodopsin orphan GPCR 0.0202 0.0762 0.0939
Brugia malayi Serotonin receptor 0.1225 0.6684 0.8324
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Schistosoma mansoni nAChR subunit 0.0306 0.1363 0.1689
Schistosoma mansoni carbonic anhydrase 0.0612 0.3134 0.3897
Echinococcus granulosus g protein coupled receptor 0.0202 0.0762 0.0949
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.086 0.4569 0.5687
Echinococcus granulosus solute carrier family 5 0.0088 0.0104 0.0129
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0136 0.0378 0.046
Schistosoma mansoni nAChR subunit 0.0136 0.0378 0.046
Echinococcus granulosus caspase 0.0306 0.1365 0.1701
Echinococcus granulosus glycine receptor subunit alpha 1 0.0412 0.1976 0.2462
Echinococcus granulosus neuropeptides capa receptor 0.0202 0.0762 0.0949
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0388 0.1837 0.228
Onchocerca volvulus 0.0136 0.0378 0.0509
Echinococcus granulosus dro:myosuppressin receptor 0.0202 0.0762 0.0949
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Onchocerca volvulus 0.0205 0.0777 0.125
Brugia malayi Trypsin family protein 0.0102 0.018 0.0213
Onchocerca volvulus 0.0202 0.0762 0.1222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0202 0.0762 0.0939
Trypanosoma brucei metacaspase MCA2 0.0306 0.1365 0.165
Brugia malayi Fli-1 protein 0.0254 0.1064 0.1316
Echinococcus granulosus potassium voltage gated channel subfamily H 0.01 0.0174 0.0216
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0412 0.1976 0.2453
Schistosoma mansoni amine GPCR 0.0202 0.0762 0.0939
Echinococcus granulosus carbonic anhydrase II 0.1457 0.8028 1
Schistosoma mansoni caspase-7 (C14 family) 0.0306 0.1365 0.1691
Loa Loa (eye worm) hypothetical protein 0.1123 0.6092 0.609
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0202 0.0762 0.1222
Echinococcus multilocularis neuropeptide Y receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0202 0.0762 0.0756
Trypanosoma brucei carbonic anhydrase-like protein 0.1457 0.8028 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0202 0.0762 0.0939
Loa Loa (eye worm) hypothetical protein 0.0418 0.2015 0.2009
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0136 0.0378 0.046
Echinococcus multilocularis caspase 2 0.1019 0.5495 0.6841
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0306 0.1363 0.1358
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1457 0.8028 1
Echinococcus granulosus transmembrane protease serine 3 0.0102 0.018 0.0224
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0306 0.1365 0.1691
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.018 0.0213
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.1365 0.1619
Loa Loa (eye worm) hypothetical protein 0.1123 0.6092 0.609
Onchocerca volvulus 0.017 0.0577 0.0879
Schistosoma mansoni voltage-gated cation channel 0.0199 0.0741 0.0913
Echinococcus granulosus tm gpcr rhodopsin 0.0202 0.0762 0.0949
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0202 0.0762 0.0949
Onchocerca volvulus 0.0202 0.0762 0.1222
Echinococcus granulosus rhodopsin orphan GPCR 0.0202 0.0762 0.0949
Brugia malayi hypothetical protein 0.0136 0.0378 0.046
Echinococcus granulosus geminin 0.0195 0.0719 0.0895
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1457 0.8028 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0136 0.0378 0.046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0202 0.0762 0.0949

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) A 0 Transfection efficiency of the compound in NCI-H23 lung cancer cell line was determined. ChEMBL. 15239653

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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