Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0329 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0857 | 0.3998 | 0.3998 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.1939 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 0.1069 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0329 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Toxoplasma gondii | hypothetical protein | 0.0329 | 0.1069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.1224 | 0.1224 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0329 | 0.1069 | 0.1069 |
Plasmodium vivax | amine transporter, putative | 0.0329 | 0.1069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0255 | 0.0255 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1939 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 0.1069 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0329 | 0.1069 | 0.1069 |
Echinococcus granulosus | kinesin family 1 | 0.105 | 0.5071 | 0.4481 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0329 | 0.1069 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1939 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0329 | 0.1069 | 0.1069 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0857 | 0.3998 | 0.3998 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 0.1069 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0329 | 0.1069 | 0.1069 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Giardia lamblia | Kinesin-5 | 0.0136 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0857 | 0.3998 | 0.3998 |
Echinococcus multilocularis | kinesin family 1 | 0.105 | 0.5071 | 0.4481 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0329 | 0.1069 | 0.1069 |
Schistosoma mansoni | hypothetical protein | 0.0914 | 0.4313 | 0.4313 |
Echinococcus multilocularis | serotonin transporter | 0.1939 | 1 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0136 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1939 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.1939 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1939 | 1 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0329 | 0.1069 | 0.1069 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1939 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 0.1069 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0357 | 0.1224 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0357 | 0.1224 | 0.5 |
Brugia malayi | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Onchocerca volvulus | 0.1939 | 1 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.0329 | 0.1069 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0357 | 0.1224 | 0.1224 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0329 | 0.1069 | 0.1069 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0329 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1069 | 0.1069 |
Echinococcus granulosus | serotonin transporter | 0.1939 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 1 |
Plasmodium falciparum | transporter, putative | 0.0329 | 0.1069 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0329 | 0.1069 | 0.1069 |
Plasmodium falciparum | amino acid transporter, putative | 0.0329 | 0.1069 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0857 | 0.3998 | 0.3998 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0329 | 0.1069 | 0.1069 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0357 | 0.1224 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1939 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1939 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0329 | 0.1069 | 0.1069 |
Plasmodium vivax | hypothetical protein, conserved | 0.0329 | 0.1069 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration Streptococcus pneumoniae UC9912 | ChEMBL. | 9733498 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration against Staphylococcus epidermis UC12084 | ChEMBL. | 9733498 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration against Enterococcus faecalis UC9217 | ChEMBL. | 9733498 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus UC6685 | ChEMBL. | 9733498 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus UC9213 | ChEMBL. | 9733498 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.