Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, theta | No references | |
Homo sapiens | protein kinase C, alpha | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0059 | 0.2135 | 0.2085 |
Echinococcus granulosus | protein kinase c iota type | 0.004 | 0.1042 | 0.2505 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0089 | 0.3972 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0073 | 0.2993 | 0.7495 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.3972 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0059 | 0.2135 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0042 | 0.1133 | 0.2736 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0059 | 0.2135 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0042 | 0.1133 | 0.1076 |
Brugia malayi | intracellular kinase | 0.0059 | 0.2135 | 0.8112 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0059 | 0.2135 | 0.53 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0059 | 0.2135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1484 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.8582 | 0.8573 |
Echinococcus granulosus | protein kinase shaggy | 0.0059 | 0.2135 | 0.53 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0059 | 0.2135 | 0.2085 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0059 | 0.2135 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0059 | 0.2135 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0042 | 0.1133 | 0.2736 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Brugia malayi | protein kinase C II. | 0.0042 | 0.1133 | 0.4188 |
Brugia malayi | Protein kinase c protein 2 | 0.0067 | 0.2617 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Schistosoma mansoni | atypical protein kinase C | 0.004 | 0.1042 | 0.2505 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Entamoeba histolytica | protein kinase, putative | 0.0059 | 0.2135 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Echinococcus granulosus | protein kinase C gamma type | 0.0073 | 0.2993 | 0.7495 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0059 | 0.2135 | 0.53 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2463 | 0.2415 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0059 | 0.2135 | 0.53 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.1484 | 0.3636 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.3972 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0089 | 0.3972 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.004 | 0.1042 | 0.2505 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.2135 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.1484 | 0.3636 |
Onchocerca volvulus | 0.0167 | 0.8582 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.1133 | 0.2736 |
Trypanosoma brucei | protein kinase, putative | 0.0059 | 0.2135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.8582 | 0.8573 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.005 | 0.1638 | 0.1584 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.8582 | 0.8573 |
Giardia lamblia | Kinase, CMGC GSK | 0.0059 | 0.2135 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0059 | 0.2135 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.2135 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0059 | 0.2135 | 0.53 |
Trichomonas vaginalis | AGC family protein kinase | 0.0024 | 0.0063 | 0.0295 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.1484 | 0.3636 |
Giardia lamblia | Kinase, CMGC GSK | 0.0059 | 0.2135 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0059 | 0.2135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9561 | 0.9558 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 nM | In Vitro Inhibition Activity Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2.1 nM | In Vitro Inhibition Activity Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.