Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast activation protein, alpha | References | |
Homo sapiens | dipeptidyl-peptidase 8 | References | |
Homo sapiens | dipeptidyl-peptidase 4 | References | |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | Dipeptidyl peptidase 9 | fibroblast activation protein, alpha | 735 aa | 597 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.005 | 0.0246 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0278 | 0.5323 | 0.5261 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.005 | 0.0246 | 0.0025 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0278 | 0.5323 | 0.5261 |
Brugia malayi | prolyl oligopeptidase family protein | 0.005 | 0.0246 | 0.0117 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.005 | 0.0246 | 0.0025 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0278 | 0.5323 | 1 |
Plasmodium falciparum | peptidase, putative | 0.005 | 0.0246 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0489 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.005 | 0.0246 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0278 | 0.5323 | 0.5217 |
Brugia malayi | prolyl oligopeptidase family protein | 0.005 | 0.0246 | 0.0117 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0489 | 1 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.005 | 0.0246 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0131 | 0.0131 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0278 | 0.5323 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.005 | 0.0246 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.005 | 0.0246 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.005 | 0.0246 | 0.0117 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0489 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.005 | 0.0246 | 0.0117 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0278 | 0.5323 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0246 | 0.0246 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0278 | 0.5323 | 0.5261 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.005 | 0.0246 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.174 | 0.174 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.005 | 0.0246 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0278 | 0.5323 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0278 | 0.5323 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.005 | 0.0246 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0489 | 1 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.005 | 0.0246 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.005 | 0.0246 | 0.0025 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0489 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0161 | 0.2724 | 0.2628 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.005 | 0.0246 | 0.0117 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.005 | 0.0246 | 0.0246 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.005 | 0.0246 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.005 | 0.0246 | 0.0117 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.005 | 0.0246 | 0.0117 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0246 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0211 | 0.3829 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2724 | 0.2724 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable peptidase | 0.005 | 0.0246 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.005 | 0.0246 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.005 | 0.0246 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.005 | 0.0246 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.005 | 0.0246 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.005 | 0.0246 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.14 nM | Inhibition of human DPP4 | ChEMBL. | 27106708 |
IC50 (binding) | = 4100 nM | Inhibition of human FAP | ChEMBL. | 27106708 |
IC50 (binding) | = 5000 nM | Inhibition of DPP8 (unknown origin) | ChEMBL. | 27106708 |
IC50 (binding) | = 0.6 uM | Inhibition of human ERG | ChEMBL. | 27106708 |
IC50 (ADMET) | > 50 uM | Inhibition of CYP2C9 (unknown origin) | ChEMBL. | 27106708 |
IC50 (ADMET) | > 50 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 27106708 |
IC50 (ADMET) | > 70 uM | Inhibition of CYP2D6 (unknown origin) | ChEMBL. | 27106708 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.