Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.1066 | 0.6927 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0045 | 0.0127 | 0.0183 |
Echinococcus multilocularis | acetylcholinesterase | 0.1062 | 0.69 | 0.9962 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0045 | 0.0127 | 0.0183 |
Brugia malayi | Carboxylesterase family protein | 0.1062 | 0.69 | 0.9962 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0184 | 0.0184 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0044 | 0.0123 | 0.0177 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0112 | 0.0574 | 0.1501 |
Onchocerca volvulus | 0.0179 | 0.1023 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0173 | 0.0977 | 0.1411 |
Echinococcus granulosus | neuroligin | 0.0179 | 0.1023 | 0.1477 |
Loa Loa (eye worm) | carboxylesterase | 0.0179 | 0.1023 | 0.1477 |
Echinococcus granulosus | acetylcholinesterase | 0.1062 | 0.69 | 0.9962 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0184 | 0.0184 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0173 | 0.0977 | 0.1411 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.0757 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1062 | 0.69 | 0.9962 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.1066 | 0.6927 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0184 | 0.0266 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0112 | 0.0574 | 0.1501 |
Loa Loa (eye worm) | carboxylesterase | 0.1062 | 0.69 | 0.9962 |
Toxoplasma gondii | thioredoxin reductase | 0.0044 | 0.0123 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0101 | 0.0499 | 0.1252 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.1066 | 0.6927 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0184 | 0.0266 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0179 | 0.1023 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0179 | 0.1023 | 0.1023 |
Onchocerca volvulus | 0.0179 | 0.1023 | 1 | |
Trypanosoma brucei | trypanothione reductase | 0.0044 | 0.0123 | 0.0177 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0101 | 0.0499 | 0.1252 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0278 | 0.1678 | 0.1678 |
Brugia malayi | Choline O-acetyltransferase | 0.0173 | 0.0977 | 0.1411 |
Schistosoma mansoni | gliotactin | 0.0179 | 0.1023 | 0.1023 |
Leishmania major | trypanothione reductase | 0.0044 | 0.0123 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0977 | 0.1411 |
Echinococcus multilocularis | neuroligin | 0.0179 | 0.1023 | 0.1477 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0179 | 0.1023 | 0.1023 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0101 | 0.0499 | 0.1252 |
Echinococcus granulosus | carboxylesterase 5A | 0.1062 | 0.69 | 0.9962 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.1066 | 0.6927 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0179 | 0.1023 | 0.1023 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.1066 | 0.6927 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1066 | 0.6927 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.1066 | 0.6927 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0179 | 0.1023 | 0.1477 |
Schistosoma mansoni | choline o-acyltransferase | 0.0173 | 0.0977 | 0.0977 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.0123 | 0.0177 |
Leishmania major | N-myristoyl transferase, putative | 0.1066 | 0.6927 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.1066 | 0.6927 | 0.6927 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0701 | 0.4492 | 0.5876 |
Brugia malayi | Thioredoxin reductase | 0.0044 | 0.0123 | 0.0177 |
Brugia malayi | Carboxylesterase family protein | 0.1062 | 0.69 | 0.9962 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0179 | 0.1023 | 0.1023 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.0757 | 0.1092 |
Onchocerca volvulus | 0.0179 | 0.1023 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0184 | 0.0266 |
Echinococcus multilocularis | acetylcholinesterase | 0.1062 | 0.69 | 0.9962 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.1066 | 0.6927 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0184 | 0.0266 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1066 | 0.6927 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0184 | 0.0266 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0101 | 0.0499 | 0.1252 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0112 | 0.0574 | 0.1501 |
Loa Loa (eye worm) | glutathione reductase | 0.0044 | 0.0123 | 0.0177 |
Brugia malayi | Carboxylesterase family protein | 0.0179 | 0.1023 | 0.1477 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0179 | 0.1023 | 0.1477 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0112 | 0.0574 | 1 |
Mycobacterium tuberculosis | Possible exported protein | 0.0496 | 0.3133 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0179 | 0.1023 | 0.2993 |
Brugia malayi | Choline O-acetyltransferase | 0.0173 | 0.0977 | 0.1411 |
Brugia malayi | Carboxylesterase family protein | 0.0179 | 0.1023 | 0.1477 |
Echinococcus granulosus | choline O acetyltransferase | 0.0173 | 0.0977 | 0.1411 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0184 | 0.0184 |
Brugia malayi | Carboxylesterase family protein | 0.0179 | 0.1023 | 0.1477 |
Echinococcus granulosus | acetylcholinesterase | 0.1062 | 0.69 | 0.9962 |
Onchocerca volvulus | 0.0179 | 0.1023 | 1 | |
Brugia malayi | glutathione reductase | 0.0044 | 0.0123 | 0.0177 |
Loa Loa (eye worm) | carboxylesterase | 0.0179 | 0.1023 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.1062 | 0.69 | 0.9962 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.1066 | 0.6927 | 1 |
Brugia malayi | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1023 | 0.1477 |
Giardia lamblia | CDC72 | 0.1066 | 0.6927 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0179 | 0.1023 | 0.1023 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1062 | 0.69 | 0.69 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1062 | 0.69 | 0.9962 |
Loa Loa (eye worm) | hypothetical protein | 0.1062 | 0.69 | 0.9962 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0179 | 0.1023 | 0.1477 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.0757 | 0.1092 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0179 | 0.1023 | 0.1477 |
Mycobacterium tuberculosis | Probable reductase | 0.0101 | 0.0499 | 0.1252 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0179 | 0.1023 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0179 | 0.1023 | 0.1477 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0101 | 0.0499 | 0.1252 |
Brugia malayi | N-myristoyltransferase 2 | 0.1066 | 0.6927 | 1 |
Trypanosoma brucei | N-myristoyltransferase | 0.1066 | 0.6927 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0179 | 0.1023 | 0.2993 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0179 | 0.1023 | 0.1477 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0184 | 0.0266 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0179 | 0.1023 | 0.1023 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0179 | 0.1023 | 0.2993 |
Onchocerca volvulus | 0.0179 | 0.1023 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.6 nM | Binding affinity to HIV protease | ChEMBL. | 1433192 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.