TDR Targets

Basic information

Technical information

TDR Targets ID: 219059
Name: 3-[2-(3-phenylphenyl)phenyl]propanoic acid
MW: 302.366 | Formula: C21H18O2
H donors: 1 H acceptors: 2 LogP: 4.93 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCc1ccccc1c1cccc(c1)c1ccccc1
InChi: 1S/C21H18O2/c22-21(23)14-13-17-9-4-5-12-20(17)19-11-6-10-18(15-19)16-7-2-1-3-8-16/h1-12,15H,13-14H2,(H,22,23)
InChiKey: UFXYBZCEZHXISE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[2-(3-phenylphenyl)phenyl]propionic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin E receptor 3 (subtype EP3)	Starlite/ChEMBL	References
Homo sapiens	prostaglandin E receptor 4 (subtype EP4)	Starlite/ChEMBL	References
Homo sapiens	prostaglandin E receptor 2 (subtype EP2), 53kDa	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Echinococcus granulosus	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0014	0.0582	0.2583
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0305	0.1355
Toxoplasma gondii	protein kinase, putative	0.0132	0.6612	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Loa Loa (eye worm)	sugar transporter	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0014	0.0597	0.0903
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Brugia malayi	putative neuropeptide receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0009	0.0305	0.1355
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Toxoplasma gondii	sugar transporter ST1	0.0007	0.0201	0.0305
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0009	0.0305	0.1355
Brugia malayi	Dopamine receptor protein 2	0.0009	0.0305	0.1355
Plasmodium falciparum	hexose transporter	0.0047	0.2253	0.2253
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0009	0.0305	0.1355
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0305	0.1355
Brugia malayi	Dopamine receptor	0.0009	0.0305	0.1355
Toxoplasma gondii	lysine-tRNA ligase	0.001	0.0399	0.0603
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0009	0.0305	1
Brugia malayi	major facilitator superfamily protein	0.0007	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0007	0.0201	0.0894
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Leishmania major	lysyl-tRNA synthetase, putative	0.001	0.0399	0.5689
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0047	0.2253	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0009	0.0318	1
Echinococcus multilocularis	General substrate transporter	0.004	0.1918	0.851
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Onchocerca volvulus		0.0009	0.0305	1
Schistosoma mansoni	opsin-like receptor	0.0009	0.0305	0.1355
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0014	0.0597	0.0597
Plasmodium falciparum	proline--tRNA ligase	0.0016	0.0701	0.0701
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0009	0.0305	0.1355
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0014	0.0597	0.0903
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0076	0.3724	0.5632
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0305	0.1355
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0606	0.269
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0007	0.0201	0.5052
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0606	0.8651
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	synaptic vesicle 2 protein	0.0007	0.0201	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.001	0.0399	0.5689
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.001	0.0399	0.1769
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Brugia malayi	Sugar transporter family protein	0.0007	0.0201	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0016	0.0701	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0009	0.0305	0.1355
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0305	0.1355
Brugia malayi	larval opioid receptor	0.0009	0.0305	0.1355
Schistosoma mansoni	amine GPCR	0.0009	0.0305	0.1355
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0014	0.0582	0.9752
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0305	0.1355
Brugia malayi	GnHR receptor homolog	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trypanosoma brucei	glucose transporter 1E	0.0015	0.0606	0.8651
Trypanosoma brucei	glucose transporter 2A	0.0015	0.0606	0.8651
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0014	0.0597	0.0597
Echinococcus multilocularis	somatostatin receptor	0.0009	0.0305	0.1355
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0076	0.3724	0.3724
Brugia malayi	neuropeptide F receptor	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Echinococcus granulosus	solute carrier family 22	0.0007	0.0201	0.0894
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0014	0.0582	0.2583
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Echinococcus multilocularis	serotonin receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	melatonin receptor type 1A	0.0009	0.0305	0.1355
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0201	0.0894
Schistosoma mansoni	glucose transporter	0.0007	0.0201	0.0894
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0014	0.0582	0.2583
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0305	0.1355
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Echinococcus granulosus	7TM GPCR rhodopsin	0.0009	0.0305	0.1355
Schistosoma mansoni	amine GPCR	0.0009	0.0305	0.1355
Brugia malayi	RE15519p	0.0009	0.0305	0.1355
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0009	0.0305	0.1355
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0047	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0076	0.3724	0.3724
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	neuropeptide FF receptor 2	0.0009	0.0305	0.1355
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trypanosoma cruzi	hexose transporter, putative	0.0007	0.0201	0.2874
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0047	0.2253	1
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0305	0.1355
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0009	0.0318	0.5469
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0005	0.0119	0.2978
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0305	0.1355
Schistosoma mansoni	protein kinase	0.0014	0.0597	0.2648
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0305	0.1355
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0009	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trypanosoma cruzi	sugar transporter, putative	0.0007	0.0201	0.2874
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0606	0.269
Brugia malayi	Dopamine receptor protein 1	0.0009	0.0305	0.1355
Entamoeba histolytica	protein kinase, putative	0.0014	0.0597	1
Echinococcus granulosus	serotonin receptor	0.0009	0.0305	0.1355
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0014	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0305	0.1355
Brugia malayi	neuropeptide F receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0606	0.269
Echinococcus granulosus	General substrate transporter	0.004	0.1918	0.851
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0009	0.0305	0.1355
Brugia malayi	major facilitator superfamily protein	0.0007	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0047	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0198	1	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0007	0.0201	0.0894
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0305	0.1355
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0016	0.0701	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0007	0.0201	0.2874
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0305	0.1355
Schistosoma mansoni	sugar transporter	0.0007	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Brugia malayi	Cam kinase protein 1	0.0014	0.0597	0.2648
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.001	0.0399	0.5689
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Schistosoma mansoni	glucose transport protein	0.0047	0.2253	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	allatostatin A receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0305	0.1355
Schistosoma mansoni	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Giardia lamblia	Hexose transporter	0.0007	0.0201	0.346
Echinococcus granulosus	sex peptide receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0009	0.0305	0.1355
Giardia lamblia	Lysyl-tRNA synthetase	0.001	0.0399	0.6849
Brugia malayi	G-protein coupled receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0009	0.0305	0.1355
Schistosoma mansoni	hypothetical protein	0.0009	0.0305	0.1355
Giardia lamblia	Sugar-proton symporter	0.0007	0.0201	0.346
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0015	0.0606	0.8651
Onchocerca volvulus		0.0009	0.0305	1
Leishmania major	glucose transporter, lmgt3	0.0015	0.0606	0.8651
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Brugia malayi	Melatonin receptor type 1A	0.0009	0.0305	0.1355
Echinococcus granulosus	orexin receptor type 2	0.0009	0.0305	0.1355
Trypanosoma cruzi	hexose transporter	0.0015	0.0606	0.8651
Echinococcus multilocularis	g-protein coupled receptor	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0597	0.2648
Brugia malayi	lysyl-tRNA synthetase	0.001	0.0399	0.1769
Echinococcus granulosus	solute carrier family 22	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Mycobacterium ulcerans	sugar transporter	0.0007	0.0201	0.5052
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0009	0.0305	0.1355
Brugia malayi	Major Facilitator Superfamily protein	0.0007	0.0201	0.0894
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0305	0.1355
Leishmania major	myo-inositol/proton symporter (MIT)	0.0007	0.0201	0.2874
Leishmania major	protein kinase, putative	0.0014	0.0597	0.8517
Loa Loa (eye worm)	hypothetical protein	0.001	0.0399	0.1769
Giardia lamblia	Prolyl-tRNA synthetase	0.0014	0.0582	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0014	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0448	0.1987
Toxoplasma gondii	sugar transporter ST2	0.0007	0.0201	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Echinococcus multilocularis	serotonin receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0014	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0016	0.0701	1
Brugia malayi	hypothetical protein	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0009	0.0305	0.1355
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0009	0.0318	1
Onchocerca volvulus		0.0009	0.0305	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0014	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0009	0.0305	0.1355
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0305	0.1355
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0014	0.0597	0.8517
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0016	0.0701	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0009	0.0305	0.1355
Schistosoma mansoni	amine GPCR	0.0009	0.0305	0.1355
Echinococcus multilocularis	solute carrier family 22	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0014	0.0582	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0047	0.2253	0.3408
Schistosoma mansoni	protein kinase	0.0014	0.0597	0.2648
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.001	0.0399	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0305	0.1355
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	dro:myosuppressin receptor	0.0009	0.0305	0.1355
Toxoplasma gondii	transporter, major facilitator family protein	0.0007	0.0201	0.0305
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0582	0.2583
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Chlamydia trachomatis	proline--tRNA ligase	0.0005	0.0119	0.2978
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Trypanosoma brucei	sugar transporter, putative	0.0007	0.0201	0.2874
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0009	0.0305	0.1355
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0014	0.0597	0.0597
Leishmania major	hypothetical protein, conserved	0.0007	0.0201	0.2874
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0007	0.0201	1
Schistosoma mansoni	sugar transporter	0.0007	0.0201	0.0894
Echinococcus multilocularis	neuropeptide receptor A26	0.0009	0.0305	0.1355
Loa Loa (eye worm)	sugar transporter	0.0047	0.2253	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0007	0.0201	0.0894
Echinococcus multilocularis	orexin receptor type 2	0.0009	0.0305	0.1355
Trypanosoma cruzi	hexose transporter, putative	0.0008	0.027	0.386
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0014	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0606	0.269
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0009	0.0305	0.1355
Echinococcus granulosus	calcium dependent protein kinase	0.0013	0.0552	0.2448
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0014	0.0597	0.2648
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0007	0.0201	0.6328
Echinococcus multilocularis	neuropeptide s receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Brugia malayi	G protein-coupled receptor F59B2.13	0.0009	0.0305	0.1355
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0016	0.0701	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Schistosoma mansoni	neuropeptide f receptor 76f	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Brugia malayi	Serotonin receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0305	0.1355
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0014	0.0597	0.0597
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0015	0.0606	0.8651
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Plasmodium vivax	hexose transporter	0.0047	0.2253	0.2253
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0047	0.2253	1
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0009	0.0305	0.1355
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0009	0.0305	0.1355
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Plasmodium falciparum	protein kinase 7	0.0132	0.6612	0.6612
Schistosoma mansoni	glucose transport protein	0.0047	0.2253	1
Leishmania major	glucose transporter, lmgt1	0.0015	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0014	0.0597	0.2648
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0597	0.2648
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0014	0.0597	0.2648
Trichomonas vaginalis	sugar transport protein, putative	0.0007	0.0201	0.0894
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0009	0.0305	0.1355
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0014	0.0597	0.2648
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0016	0.0701	0.106
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.001	0.0399	1
Echinococcus granulosus	solute carrier family 22	0.0007	0.0201	0.0894
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0014	0.0597	0.0597
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0014	0.0582	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Brugia malayi	G-protein coupled receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0305	0.1355
Brugia malayi	AKH receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	neuropeptide receptor A26	0.0009	0.0305	0.1355
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0305	0.1355
Plasmodium vivax	proline--tRNA ligase, putative	0.0016	0.0701	0.0701
Plasmodium vivax	sugar transporter, putative	0.0007	0.0201	0.0201
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0014	0.0597	0.0597
Echinococcus granulosus	somatostatin receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0582	0.2583
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0007	0.0201	0.0201
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0014	0.0597	0.0903
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0047	0.2253	1
Brugia malayi	G protein-coupled receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0305	0.1355
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0015	0.0606	0.8651
Echinococcus multilocularis	lysyl tRNA synthetase	0.001	0.0399	0.1769
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0009	0.0305	0.1355
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Echinococcus granulosus	fmrfamide receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0047	0.2253	1
Schistosoma mansoni	opsin-like receptor	0.0009	0.0305	0.1355
Brugia malayi	Sugar transporter family protein	0.0047	0.2253	1
Brugia malayi	Major Facilitator Superfamily protein	0.0007	0.0201	0.0894
Loa Loa (eye worm)	TYRA-2 protein	0.0009	0.0305	0.1355
Brugia malayi	sulfakinin receptor protein	0.0009	0.0305	0.1355
Schistosoma mansoni	amine GPCR	0.0009	0.0305	0.1355
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0305	0.1355
Chlamydia trachomatis	lysine--tRNA ligase	0.001	0.0399	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0013	0.0552	0.2448
Echinococcus granulosus	7tm_1 domain containing protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Brugia malayi	Major Facilitator Superfamily protein	0.0007	0.0201	0.0894
Echinococcus granulosus	neuropeptide s receptor	0.0009	0.0305	0.1355
Treponema pallidum	prolyl-tRNA synthetase	0.0005	0.0119	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0007	0.0201	0.0894
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0009	0.0305	0.1355
Entamoeba histolytica	protein kinase, putative	0.0014	0.0597	1
Brugia malayi	ORL1-like opioid receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0047	0.2253	1
Leishmania major	glucose transporter, lmgt2	0.0015	0.0606	0.8651
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	solute carrier family 22	0.0007	0.0201	0.0894
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0007	0.0201	0.0894
Schistosoma mansoni	adenoreceptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0606	0.269
Onchocerca volvulus		0.0009	0.0305	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0007	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0015	0.0606	0.8651
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	G protein coupled receptor 139	0.0009	0.0305	0.1355
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Schistosoma mansoni	amine GPCR	0.0009	0.0305	0.1355
Mycobacterium ulcerans	integral membrane transport protein	0.0007	0.0201	0.5052
Echinococcus multilocularis	G protein coupled receptor 139	0.0009	0.0305	0.1355
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0009	0.0305	0.1355
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0014	0.0597	0.0597
Onchocerca volvulus		0.0009	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Onchocerca volvulus		0.0009	0.0305	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Brugia malayi	Serotonin receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0305	0.1355
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0305	0.1355
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.001	0.0399	0.6849
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0606	0.8651
Onchocerca volvulus		0.0009	0.0305	1
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Brugia malayi	follicle stimulating hormone receptor	0.0009	0.0305	0.1355
Schistosoma mansoni	glucose transport protein	0.0047	0.2253	1
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0007	0.0201	0.0894
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0007	0.0201	0.5052
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trypanosoma brucei	glucose transporter, putative	0.0015	0.0606	0.8651
Schistosoma mansoni	lysyl-tRNA synthetase	0.001	0.0399	0.1769
Onchocerca volvulus		0.0009	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0582	0.2583
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0606	0.8651
Echinococcus granulosus	lysyl tRNA synthetase	0.001	0.0399	0.1769
Plasmodium falciparum	lysine--tRNA ligase	0.001	0.0399	0.0399
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0305	0.1355
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0305	0.1355
Schistosoma mansoni	histamine h1 receptor	0.0009	0.0305	0.1355
Plasmodium vivax	lysine--tRNA ligase, putative	0.001	0.0399	0.0399
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0009	0.0305	0.1355
Schistosoma mansoni	myosin xvIII	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus granulosus	g-protein coupled receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0606	0.269
Onchocerca volvulus		0.0009	0.0305	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Schistosoma mansoni	opsin-like receptor	0.0009	0.0305	0.1355
Schistosoma mansoni	growth hormone secretagogue receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0009	0.0305	0.1355
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0014	0.0597	0.0597
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0007	0.0201	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0007	0.0201	0.0894
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0305	0.1355
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0014	0.0597	0.2648
Trypanosoma cruzi	glucose transporter, putative	0.0007	0.0201	0.2874
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0009	0.0305	0.1355
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0006	0.016	0.0709
Echinococcus multilocularis	allatostatin A receptor	0.0009	0.0305	0.1355
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Echinococcus multilocularis	sex peptide receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Brugia malayi	hypothetical protein	0.0007	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0009	0.0333	0.1477
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0009	0.0305	0.1355
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0014	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0009	0.0305	0.1355
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0007	0.0201	0.6328
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0047	0.2253	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0014	0.0597	0.2648
Trichomonas vaginalis	CAMK family protein kinase	0.0014	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0305	0.1355
Onchocerca volvulus		0.0009	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Toxoplasma gondii	sugar transporter ST3	0.0007	0.0201	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0201	0.0894
Schistosoma mansoni	lysyl-tRNA synthetase	0.001	0.0399	0.1769
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0009	0.0305	0.1355
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0009	0.0305	0.1355
Brugia malayi	putative neuropeptide receptor NPR1	0.0009	0.0305	0.1355
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0014	0.0582	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0007	0.0201	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0014	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Entamoeba histolytica	hypothetical protein	0.001	0.0399	0.6679
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0305	0.1355
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	sugar transporter, putative	0.0007	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0007	0.0201	0.0894
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0014	0.0582	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0305	0.1355
Trichomonas vaginalis	myo-inositol transporter, putative	0.0007	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0305	0.1355
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0009	0.0305	0.1355

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.75 uM	Affinity at human Prostanoid EP3 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786
Ki (binding)	= 0.75 uM	Affinity at human Prostanoid EP3 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786
Ki (binding)	= 6 uM	Affinity at human Prostanoid EP4 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786
Ki (binding)	= 6 uM	Affinity at human Prostanoid EP4 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786
Ki (binding)	= 8.1 uM	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786
Ki (binding)	= 8.1 uM	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786
Ki (binding)	= 34 uM	Affinity at human Prostanoid EP1 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786
Ki (binding)	= 34 uM	Affinity at human Prostanoid EP1 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL.	14552786

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL126472
PubChem: 9944231

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 219059