Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.1225 | 0.0719 | 1 |
Loa Loa (eye worm) | STE/STE11/MEKK2 protein kinase | 0.0181 | 0.0027 | 0.0022 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0423 | 0.0188 | 0.1059 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1703 | 0.1035 | 0.5846 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 0.0207 | 0.108 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0197 | 0.0038 | 0.0076 |
Echinococcus multilocularis | partitioning defective protein 6 | 0.0176 | 0.0024 | 0.0133 |
Brugia malayi | Matrixin family protein | 0.125 | 0.0735 | 0.4485 |
Brugia malayi | Partitioning defective-6 homolog alpha | 0.0176 | 0.0024 | 0.0001 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0248 | 0.0072 | 0.0282 |
Echinococcus granulosus | protein kinase C gamma type | 0.0248 | 0.0072 | 0.0404 |
Echinococcus granulosus | NDR protein kinase | 0.0248 | 0.0072 | 0.0404 |
Echinococcus granulosus | unc 13 munc13 | 0.0175 | 0.0023 | 0.0132 |
Brugia malayi | C1-like domain containing protein | 0.0181 | 0.0027 | 0.0022 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0235 | 0.0063 | 0.025 |
Schistosoma mansoni | cell polarity protein | 0.0176 | 0.0024 | 0.0001 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0248 | 0.0072 | 0.0404 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0181 | 0.0027 | 0.0019 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0248 | 0.0072 | 0.0404 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0175 | 0.0023 | 0.0132 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1703 | 0.1035 | 0.5846 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0175 | 0.0023 | 0.0132 |
Entamoeba histolytica | protein kinase, putative | 0.0248 | 0.0072 | 1 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0175 | 0.0023 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0189 | 0.0969 |
Brugia malayi | Hemopexin family protein | 0.0478 | 0.0224 | 0.1262 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0175 | 0.0023 | 0.0132 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0248 | 0.0072 | 0.0404 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0175 | 0.0023 | 0.0132 |
Echinococcus multilocularis | protein kinase c eta type | 0.0175 | 0.0023 | 0.0132 |
Onchocerca volvulus | Protein TFG homolog | 0.0176 | 0.0024 | 0.0002 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Loa Loa (eye worm) | PAR-6 protein | 0.0176 | 0.0024 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0024 | 0.0001 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0248 | 0.0072 | 0.0282 |
Echinococcus granulosus | protein kinase c eta type | 0.0175 | 0.0023 | 0.0132 |
Leishmania major | hypothetical protein, conserved | 0.0176 | 0.0024 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0248 | 0.0072 | 0.0404 |
Brugia malayi | Protein kinase domain containing protein | 0.0181 | 0.0027 | 0.0022 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.2747 | 0.1727 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0248 | 0.0072 | 1 |
Trypanosoma cruzi | PB1 domain containing protein, putative | 0.0176 | 0.0024 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.2814 | 0.1771 | 1 |
Onchocerca volvulus | 0.0181 | 0.0027 | 0.0053 | |
Mycobacterium ulcerans | histidinol dehydrogenase | 1.524 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0248 | 0.0072 | 0.0303 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0175 | 0.0023 | 0.0132 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.0072 | 0.0258 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0425 | 0.0189 | 0.0969 |
Onchocerca volvulus | 0.0425 | 0.0189 | 0.2374 | |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0189 | 0.0969 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0176 | 0.0024 | 0.0033 |
Brugia malayi | Protein kinase c protein 2 | 0.0181 | 0.0027 | 0.0022 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0248 | 0.0072 | 0.0404 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0248 | 0.0072 | 0.0282 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0772 | 0.0419 | 0.2122 |
Schistosoma mansoni | serine/threonine kinase | 0.0248 | 0.0072 | 0.0258 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0453 | 0.0207 | 0.1159 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0423 | 0.0188 | 0.0881 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.0055 | 0.0311 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0248 | 0.0072 | 0.0282 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0175 | 0.0023 | 0.0132 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0248 | 0.0072 | 0.0282 |
Echinococcus granulosus | myotubularin protein 13 | 0.0175 | 0.0023 | 0.0132 |
Loa Loa (eye worm) | zinc finger protein | 0.0176 | 0.0024 | 0.0001 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Onchocerca volvulus | 0.0176 | 0.0024 | 0.0002 | |
Brugia malayi | Protein kinase domain containing protein | 0.0181 | 0.0027 | 0.0023 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0423 | 0.0188 | 0.0964 |
Echinococcus multilocularis | N chimaerin | 0.0175 | 0.0023 | 0.0132 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0175 | 0.0023 | 0.0132 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0248 | 0.0072 | 0.0404 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0423 | 0.0188 | 0.0881 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.0055 | 0.0169 |
Onchocerca volvulus | Matrilysin homolog | 0.0425 | 0.0189 | 0.2374 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 1.524 | 1 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0423 | 0.0188 | 0.1059 |
Schistosoma mansoni | protein kinase C mu | 0.0181 | 0.0027 | 0.0019 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0197 | 0.0038 | 0.0212 |
Brugia malayi | protein kinase C II. | 0.0423 | 0.0188 | 0.1035 |
Echinococcus multilocularis | protein TFG | 0.0176 | 0.0024 | 0.0133 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.2989 | 0.1887 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.125 | 0.0735 | 0.4179 |
Onchocerca volvulus | 0.0478 | 0.0224 | 0.2879 | |
Brugia malayi | Matrixin family protein | 0.0425 | 0.0189 | 0.104 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0175 | 0.0023 | 0.0132 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0175 | 0.0023 | 0.0132 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.0072 | 0.0258 |
Brugia malayi | Protein kinase domain containing protein | 0.0248 | 0.0072 | 0.0303 |
Entamoeba histolytica | protein kinase, putative | 0.0248 | 0.0072 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0248 | 0.0072 | 1 |
Brugia malayi | Matrixin family protein | 0.0425 | 0.0189 | 0.104 |
Schistosoma mansoni | hypothetical protein | 0.0478 | 0.0224 | 0.1074 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0248 | 0.0072 | 0.0282 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0175 | 0.0023 | 0.0132 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0248 | 0.0072 | 0.0282 |
Loa Loa (eye worm) | matrixin family protein | 0.0878 | 0.0489 | 0.2731 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.0063 | 0.0233 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0248 | 0.0072 | 0.0404 |
Entamoeba histolytica | protein kinase, putative | 0.0248 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0218 | 0.114 |
Brugia malayi | Matrixin family protein | 0.0425 | 0.0189 | 0.104 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0248 | 0.0072 | 0.0404 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0181 | 0.0027 | 0.0152 |
Toxoplasma gondii | AGC kinase | 0.0248 | 0.0072 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0197 | 0.0038 | 0.0212 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0181 | 0.0027 | 0.0021 |
Trypanosoma cruzi | PB1 domain containing protein, putative | 0.0176 | 0.0024 | 0.5 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0175 | 0.0023 | 0.0132 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0423 | 0.0188 | 0.1059 |
Brugia malayi | protein kinase C3,putative | 0.2571 | 0.161 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0248 | 0.0072 | 0.0404 |
Echinococcus granulosus | protein TFG | 0.0176 | 0.0024 | 0.0133 |
Echinococcus granulosus | protein kinase c iota type | 0.2814 | 0.1771 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.0072 | 0.0258 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0878 | 0.0489 | 0.6688 |
Brugia malayi | Hr1 repeat family protein | 0.0248 | 0.0072 | 0.0303 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0423 | 0.0188 | 0.1059 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0423 | 0.0188 | 0.0881 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0248 | 0.0072 | 0.0303 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0181 | 0.0027 | 0.0022 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0181 | 0.0027 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0072 | 0.0282 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.0072 | 0.0258 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.007 | 0.0394 |
Brugia malayi | Matrixin family protein | 0.0425 | 0.0189 | 0.104 |
Echinococcus granulosus | N chimaerin | 0.0175 | 0.0023 | 0.0132 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0248 | 0.0072 | 0.0404 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0181 | 0.0027 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 0.0419 | 0.2322 |
Brugia malayi | Protein kinase domain containing protein | 0.0248 | 0.0072 | 0.0303 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.0072 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0248 | 0.0072 | 0.0404 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.