Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.003 | 0.4361 | 0.4361 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.3948 | 0.3948 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0032 | 0.4752 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0032 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0009 | 0.0042 | 0.0056 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0028 | 0.3948 | 0.3889 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0021 | 0.2547 | 0.3708 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.003 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.002 | 0.2228 | 0.2981 |
Loa Loa (eye worm) | fatty acid synthase | 0.003 | 0.4277 | 0.4318 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.001 | 0.0229 | 0.0306 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0029 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0029 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0025 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | thioesterase | 0.0025 | 0.3311 | 0.443 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0045 | 0.7476 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.003 | 0.4361 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.002 | 0.2149 | 0.2574 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0045 | 0.7476 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0009 | 0.0042 | 0.0056 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.002 | 0.2228 | 0.2941 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0025 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0032 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.003 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0028 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0045 | 0.7476 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0032 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.003 | 0.4361 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0024 | 0.3131 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0024 | 0.3131 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.003 | 0.4361 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0025 | 0.3311 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.002 | 0.2228 | 0.2981 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0032 | 0.4752 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0054 | 0.9416 | 1 |
Onchocerca volvulus | 0.0052 | 0.9025 | 0.9285 | |
Mycobacterium ulcerans | polyketide synthase | 0.003 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0012 | 0.061 | 0.0817 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0025 | 0.3311 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0017 | 0.1644 | 0.2199 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.003 | 0.4361 | 0.5834 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0032 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0022 | 0.2588 | 0.3461 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0032 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.003 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0032 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0045 | 0.7476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.8643 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0032 | 0.4752 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.003 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0032 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.003 | 0.4361 | 0.5834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.