Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measured after 30 mins | ChEMBL. | 24900454 | |
IC50 (binding) | = 14 nM | Inhibition of rat acetylcholinesterase (AChE) | ChEMBL. | 9767635 |
IC50 (binding) | = 14 nM | Inhibition of rat acetylcholinesterase (AChE) | ChEMBL. | 9767635 |
IC50 (binding) | = 14 nM | Inhibition of AChE | ChEMBL. | 20053484 |
IC50 (binding) | = 14 nM | Inhibition of acetylcholinesterase (unknown origin) | ChEMBL. | No reference |
IC50 (binding) | = 8.68 uM | Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 mins | ChEMBL. | 24900454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.