Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 mmHg | Maximum fall in blood pressure in groups of four sodium-depleted rats,after per oral administration; Not tested | ChEMBL. | 9046346 |
IC50 (binding) | = 6.92 | Antagonist activity at AT1 receptor in Rattus norvegicus (rat) liver | ChEMBL. | No reference |
IC50 (binding) | = 120 nM | In vitro binding affinity for rat liver angiotensin II receptor type 1, determined by displacement of the specially bound [3H]-AII radioligand | ChEMBL. | 9046346 |
IC50 (binding) | = 120 nM | In vitro binding affinity for rat liver angiotensin II receptor type 1, determined by displacement of the specially bound [3H]-AII radioligand | ChEMBL. | 9046346 |
IC50 (binding) | = 120 nM | Antagonist activity at AT1 receptor in Rattus norvegicus (rat) liver | ChEMBL. | No reference |
Inhibition (functional) | = 61.2 % | Percent peak inhibition of pressor response induced by exogenously administered AII at 1 mg/kg in 2 or more pithed rats. | ChEMBL. | 9046346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.