Detailed information for compound 225829

Basic information

Technical information
  • TDR Targets ID: 225829
  • Name: 5-[[4-[2-[methyl-(5-methylpyridin-2-yl)amino] ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-di one
  • MW: 371.453 | Formula: C19H21N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccc(cn1)C)C
  • InChi: 1S/C19H21N3O3S/c1-13-3-8-17(20-12-13)22(2)9-10-25-15-6-4-14(5-7-15)11-16-18(23)21-19(24)26-16/h3-8,12,16H,9-11H2,1-2H3,(H,21,23,24)
  • InChiKey: PDOUWTYEQULSSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[4-[2-[methyl-(5-methyl-2-pyridyl)amino]ethoxy]phenyl]methyl]thiazolidine-2,4-dione
  • 5-[4-[2-[methyl-(5-methyl-2-pyridyl)amino]ethoxy]benzyl]thiazolidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Schistosoma mansoni hypothetical protein 0.0171 0.0259 0.0253
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0043 0.0035 0.0112
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0043 0.0035 0.0029
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0043 0.0035 0.0029
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0314 0.0511 0.1967
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0035 0.0136
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0035 0.0136
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0129 0.0186 0.0723
Echinococcus multilocularis geminin 0.0171 0.0259 0.0986
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.0505 0.8584
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0043 0.0035 0.0112
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0043 0.0035 0.0112
Brugia malayi Zinc knuckle family protein 0.0129 0.0186 0.07
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0508
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0129 0.0186 0.0723
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0043 0.0035 0.0112
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0043 0.0035 0.0029
Trypanosoma brucei ingi protein (ORF1) 0.1613 0.2798 0.2791
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma brucei hypothetical protein, conserved 0.1613 0.2798 0.2791
Brugia malayi hypothetical protein 0.0129 0.0186 0.07
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0043 0.0035 0.0029
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0129 0.0186 0.0595
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0015
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0129 0.0186 0.0176
Trypanosoma brucei RNA helicase, putative 0.5704 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0314 0.0511 0.1967
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0043 0.0035 0.0112
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0129 0.0186 0.07
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0043 0.0035 0.0029
Brugia malayi reverse transcriptase 0.0129 0.0186 0.07
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0129 0.0186 0.0176
Brugia malayi Importin beta-1 subunit 0.0029 0.001 0.0013
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0043 0.0035 0.0136
Schistosoma mansoni phosphoglucomutase 0.1484 0.2571 0.2566
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0049 0.0166
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0049 0.0055
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0049 0.0043
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Leishmania major cAMP-specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Echinococcus multilocularis snurportin 1 0.031 0.0505 0.1944
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 1
Schistosoma mansoni importin beta-1 0.0029 0.001 0.0003
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Brugia malayi Zinc knuckle family protein 0.0129 0.0186 0.07
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0043 0.0035 0.0112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0043 0.0035 0.0112
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0043 0.0035 0.0136
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0035 0.0136
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0049 0.019
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0043 0.0035 0.0112
Echinococcus granulosus KRAB A domain containing protein 0.0129 0.0186 0.07
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0043 0.0035 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0357 0.0587 0.2255
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Schistosoma mansoni hypothetical protein 0.0129 0.0186 0.018
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0049 0.0153
Brugia malayi RNase H family protein 0.1484 0.2571 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0049 0.019
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0043 0.0035 0.0508
Echinococcus granulosus geminin 0.0171 0.0259 0.0986
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0049 0.019
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Plasmodium falciparum phosphodiesterase delta, putative 0.0043 0.0035 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0049 0.019
Echinococcus granulosus importin subunit beta 1 0.0029 0.001 0.0013
Echinococcus granulosus RNA directed DNA polymerase 0.0129 0.0186 0.07
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0129 0.0186 0.0595
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0035 0.0136
Plasmodium falciparum phosphodiesterase gamma, putative 0.0043 0.0035 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0232 0.0367 0.0361
Brugia malayi hypothetical protein 0.0129 0.0186 0.07
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0314 0.0511 0.8684
Plasmodium vivax phosphodiesterase gamma, putative 0.0043 0.0035 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.001 0.0013
Trypanosoma cruzi ribonuclease H1, putative 0.1484 0.2571 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Onchocerca volvulus 0.0129 0.0186 0.07
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma brucei protein kinase, putative 0.0051 0.0049 0.0039
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Brugia malayi reverse transcriptase 0.0129 0.0186 0.07
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0043 0.0035 0.0029
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0043 0.0035 0.0029
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0043 0.0035 0.0112
Trichomonas vaginalis reverse transcriptases, putative 0.0129 0.0186 0.0723
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0043 0.0035 0.0112
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0129 0.0186 0.07
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0049 0.0166
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0357 0.0587 0.2266
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0043 0.0035 0.0112
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0043 0.0035 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Schistosoma mansoni hypothetical protein 0.031 0.0505 0.0499
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0035 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Trypanosoma brucei unspecified product 0.1613 0.2798 0.2791
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0043 0.0035 0.0112
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0043 0.0035 0.0025
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0357 0.0587 0.2266
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0035 0.0136
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Trypanosoma brucei ribonuclease H1 0.1484 0.2571 0.2564
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.1484 0.2571 0.5
Mycobacterium tuberculosis Possible maturase 0.0129 0.0186 0.5
Loa Loa (eye worm) hypothetical protein 0.0357 0.0587 1
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.1613 0.2798 0.2791
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0129 0.0186 0.07
Giardia lamblia Reverse transcriptase/endonuclease 0.0129 0.0186 0.0595
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.0072
Brugia malayi RNA, U transporter 1 0.0083 0.0104 0.0381
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0508
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Trichomonas vaginalis ribonuclease H1, putative 0.1484 0.2571 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0049 0.019
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0049 0.019
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Echinococcus granulosus ribonuclease H1 0.1484 0.2571 1
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0129 0.0186 0.018
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0129 0.0186 0.0595
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0049 0.019
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0129 0.0186 0.07
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0043 0.0035 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0187 0.0181
Schistosoma mansoni protein kinase 0.0129 0.0186 0.018
Schistosoma mansoni phosphoglucomutase 0.1484 0.2571 0.2566
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0043 0.0035 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0043 0.0035 0.0112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0357 0.0587 0.2266
Schistosoma mansoni hypothetical protein 0.0171 0.0259 0.0253
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0006 0.0015
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0357 0.0587 0.0581
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0049 0.0166
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0129 0.0186 0.0595
Trypanosoma cruzi hypothetical protein, conserved 0.0129 0.0186 0.0723
Loa Loa (eye worm) PDE1B protein 0.0043 0.0035 0.0508
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0043 0.0035 0.0112
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0035 0.0136
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1276 0.2205 0.22
Brugia malayi hypothetical protein 0.0129 0.0186 0.07
Entamoeba histolytica hypothetical protein 0.0024 0 0.5
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 1
Brugia malayi RNase H family protein 0.1484 0.2571 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0357 0.0587 0.2178
Treponema pallidum ribonuclease H (rnhA) 0.1484 0.2571 0.5
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0043 0.0035 0.0025
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0508
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0049 0.019
Toxoplasma gondii ribonuclease HI protein 0.1484 0.2571 1
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0129 0.0186 0.07
Echinococcus granulosus snurportin 1 0.031 0.0505 0.1944
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0049 0.019
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0049 0.0039
Trypanosoma brucei ingi protein (ORF1) 0.1613 0.2798 0.2791
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Trypanosoma cruzi ribonuclease H1, putative 0.1484 0.2571 1
Brugia malayi RNase H family protein 0.1484 0.2571 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0035 0.0136
Echinococcus multilocularis RNA directed DNA polymerase 0.0129 0.0186 0.07
Brugia malayi hypothetical protein 0.0129 0.0186 0.07
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0043 0.0035 0.0029
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0129 0.0186 0.0176
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0043 0.0035 0.0112
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0043 0.0035 0.0112
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0129 0.0186 0.07
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0314 0.0511 0.1967
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0043 0.0035 0.0029
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0043 0.0035 0.0112
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0025
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0129 0.0186 0.07
Echinococcus multilocularis ribonuclease H1 0.1484 0.2571 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Leishmania major hypothetical protein, conserved 0.0043 0.0035 0.0136
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0043 0.0035 0.0029
Giardia lamblia Ribonuclease H 0.1484 0.2571 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0136
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0035 0.0025
Schistosoma mansoni hypothetical protein 0.0129 0.0186 0.018
Brugia malayi reverse transcriptase 0.0129 0.0186 0.07
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0035 0.0025
Leishmania major ribonuclease H1, putative 0.1484 0.2571 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0043 0.0035 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0357 0.0587 0.2266
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0006 0.0015
Onchocerca volvulus Ribonuclease H1 homolog 0.1484 0.2571 1
Trichomonas vaginalis reverse transcriptases, putative 0.0129 0.0186 0.0723
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0043 0.0035 0.0025
Schistosoma mansoni phosphoglucomutase 0.1484 0.2571 0.2566
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0049 0.0166
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0043 0.0035 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0035 0.0136
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0043 0.0035 0.0136
Brugia malayi MAP kinase sur-1 0.0051 0.0049 0.0166
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Brugia malayi Pao retrotransposon peptidase family protein 0.0129 0.0186 0.07
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0049 0.0747
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0035 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0049 0.019
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0035 0.0136
Leishmania major hypothetical protein, conserved 0.0043 0.0035 0.0136
Onchocerca volvulus 0.0129 0.0186 0.07

Activities

Activity type Activity value Assay description Source Reference
Reduction (functional) = 18 % Percent reduction in area under glucose tolerance curve (AUC) was determined at 30 micromol/kg dose of diet in mice ChEMBL. 7966158
Reduction (functional) = 18 % Percent reduction in area under glucose tolerance curve (AUC) was determined at 30 micromol/kg dose of diet in mice ChEMBL. 7966158
Reduction (functional) = 19 % Percent reduction in area under glucose tolerance curve at 100 uM/kg dose in diet of mice. ChEMBL. 7966158
Reduction (functional) = 19 % Percent reduction in area under glucose tolerance curve at 100 uM/kg dose in diet of mice. ChEMBL. 7966158
Reduction (functional) = 35 % Percent reduction in area under glucose tolerance curve at 300 uM/kg dose in diet of mice. ChEMBL. 7966158
Reduction (functional) = 35 % Percent reduction in area under glucose tolerance curve at 300 uM/kg dose in diet of mice. ChEMBL. 7966158

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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