Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0176 | 1 | 0.5 |
Onchocerca volvulus | 0.0176 | 1 | 0.5 | |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0176 | 1 | 0.5 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | cdc25c, putative | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0176 | 1 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0176 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 1 | 1 |
Onchocerca volvulus | 0.0176 | 1 | 0.5 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0176 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0176 | 1 | 0.5 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0176 | 1 | 0.5 |
Onchocerca volvulus | 0.0176 | 1 | 0.5 | |
Onchocerca volvulus | 0.0176 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 8.8 mg kg-1 | Intraperitoneal effective dose of the compound required for inhibition of apomorphine-induced climbing in mice | ChEMBL. | 8831770 |
ED50 (functional) | = 27.4 mg kg-1 | Intraperitoneal effective dose of the compound required for inhibition of apomorphine-induced stereotypy in rat | ChEMBL. | 8831770 |
IC50 (binding) | = 0.045 uM | Binding affinity towards serotonin 5-HT2 receptor was determined in rat cortex using [3H]-spiperone as ligand | ChEMBL. | 8831770 |
IC50 (binding) | = 0.045 uM | Binding affinity towards serotonin 5-HT2 receptor was determined in rat cortex using [3H]-spiperone as ligand | ChEMBL. | 8831770 |
IC50 (binding) | = 0.467 uM | Binding affinity of the compound towards Dopamine receptor D2 was determined in rat striatum using [3H]- spiperone as radioligand | ChEMBL. | 8831770 |
IC50 (binding) | = 0.467 uM | Binding affinity of the compound towards Dopamine receptor D2 was determined in rat striatum using [3H]- spiperone as radioligand | ChEMBL. | 8831770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.