Detailed information for compound 252090

Basic information

Technical information
  • TDR Targets ID: 252090
  • Name: 2-amino-1-(azepan-1-yl)-3-methylpentan-1-one
  • MW: 212.332 | Formula: C12H24N2O
  • H donors: 1 H acceptors: 1 LogP: 1.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(C(=O)N1CCCCCC1)N)C
  • InChi: 1S/C12H24N2O/c1-3-10(2)11(13)12(15)14-8-6-4-5-7-9-14/h10-11H,3-9,13H2,1-2H3
  • InChiKey: YRLGNCQASLTTNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-1-(azepan-1-yl)-3-methyl-pentan-1-one
  • 2-amino-1-(1-azepanyl)-3-methyl-1-pentanone
  • 2-azanyl-1-(azepan-1-yl)-3-methyl-pentan-1-one
  • 2-amino-1-(1-azepanyl)-3-methylpentan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis GTP-binding protein rit, putative 0.036 0.44 1
Schistosoma mansoni hypothetical protein 0.0081 0.0882 0.0805
Loa Loa (eye worm) hypothetical protein 0.0028 0.0221 0.0503
Schistosoma mansoni kinase 0.0047 0.0453 0.0373
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.12 1
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0224 0.008
Schistosoma mansoni DNA polymerase eta 0.0044 0.0414 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0309 0.0227
Schistosoma mansoni hypothetical protein 0.0081 0.0882 0.0805
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.3579 1
Giardia lamblia PHD finger protein 15 0.0028 0.0221 0.1311
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0796 0.0718
Echinococcus granulosus ras gtpase 0.036 0.44 0.4343
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.01 0.0016
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0224 0.008
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0675 0.0581
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0224 0.0288
Loa Loa (eye worm) hypothetical protein 0.0096 0.1074 0.2442
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0216 0.0491
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1025 0.233
Echinococcus multilocularis tumor protein p63 0.0394 0.4826 0.4774
Brugia malayi 6-phosphofructokinase 0.0106 0.12 0.2728
Echinococcus granulosus jumonji domain containing protein 0.004 0.0362 0.0264
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0285 0.0187
Onchocerca volvulus 0.0277 0.335 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1622 0.4373
Echinococcus granulosus dna polymerase eta 0.0044 0.0414 0.0317
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0589 0.051
Schistosoma mansoni cpg binding protein 0.003 0.0236 0.0154
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0224 0.724
Entamoeba histolytica Ras family GTPase 0.036 0.44 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0438 0.0786
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0414 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1025 0.2151
Echinococcus multilocularis protein dispatched 1 0.0047 0.0456 0.036
Schistosoma mansoni hypothetical protein 0.004 0.0364 0.0282
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0221 0.0503
Schistosoma mansoni microtubule-associated protein tau 0.0805 1 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.12 0.6396
Echinococcus granulosus peregrin 0.0028 0.0221 0.0123
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4896 0.4845
Echinococcus multilocularis peregrin 0.0028 0.0221 0.0123
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.01 0.0227
Schistosoma mansoni hypothetical protein 0.04 0.4896 0.4853
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.12 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0438 0.0786
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.3579 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.0882 0.0805
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0675 0.1652
Onchocerca volvulus 0.0176 0.2082 0.5955
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0224 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0383 0.0869
Loa Loa (eye worm) hypothetical protein 0.0044 0.0414 0.094
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0675 0.1337
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.01 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0383 0.0285
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.12 0.3304
Entamoeba histolytica ras-1, putative 0.036 0.44 1
Loa Loa (eye worm) hypothetical protein 0.036 0.44 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1025 0.2659
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.12 0.2559
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1025 0.2581
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0385 0.0819
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.12 0.1111
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0383 0.0657
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2928 0.6654
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0224 0.0288
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.12 0.2728
Brugia malayi Pre-SET motif family protein 0.0035 0.0309 0.0702
Schistosoma mansoni apoptosis regulator bax 0.0081 0.0882 0.0805
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0309 0.0211
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1025 0.2151
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.025 0.043
Trypanosoma brucei unspecified product 0.0019 0.01 0.0207
Onchocerca volvulus Alhambra homolog 0.0028 0.0221 0.0017
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1594 0.1509
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0383 0.0869
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.01 0.0207
Echinococcus granulosus cpg binding protein 0.003 0.0236 0.0137
Brugia malayi PHD-finger family protein 0.0028 0.0221 0.0503
Leishmania major DNA polymerase eta, putative 0.0031 0.025 0.043
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0224 0.5
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1074 0.2266
Onchocerca volvulus 0.0058 0.0589 0.1191
Brugia malayi Bromodomain containing protein 0.0028 0.0221 0.0503
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0333 0.0235
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0414 0.109
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1025 0.2659
Trichomonas vaginalis dexras1, putative 0.036 0.44 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.0882 0.0789
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0385 0.0819
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1622 0.4373
Onchocerca volvulus 0.0035 0.0309 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1025 0.2151
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0317 0.0235
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0104 0.0236
Brugia malayi Ras-related protein R-Ras2 0.036 0.44 1
Schistosoma mansoni hypothetical protein 0.004 0.0364 0.0282
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0309 0.0211
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0221 0.0123
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0675 0.1534
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1038 0.0947
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.3579 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1074 0.2442
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1594 0.1509
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.3579 1
Echinococcus multilocularis protein patched 0.0041 0.0383 0.0285
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1074 0.0984
Echinococcus multilocularis cpg binding protein 0.003 0.0236 0.0137
Brugia malayi CXXC zinc finger family protein 0.0028 0.0216 0.0491
Echinococcus multilocularis ras gtpase 0.036 0.44 0.4343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0309 0.0227
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.12 0.6396
Brugia malayi CHE-14 protein 0.0041 0.0383 0.0869
Echinococcus multilocularis dna polymerase eta 0.0044 0.0414 0.0317
Echinococcus multilocularis expressed conserved protein 0.009 0.1001 0.091
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0383 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Plasmodium falciparum phd finger protein, putative 0.0028 0.0221 0.9883
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1093 0.1018
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0675 0.0596
Brugia malayi Ras protein let-60 0.036 0.44 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.025 0.0869
Schistosoma mansoni cpg binding protein 0.003 0.0236 0.0154
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0675 0.1652
Schistosoma mansoni hypothetical protein 0.004 0.0364 0.0282
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0224 0.724
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.12 0.3162
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.12 0.2559
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0414 0.094
Trichomonas vaginalis rheb, putative 0.036 0.44 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.0882 0.0789
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.12 0.1126
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.01 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Loa Loa (eye worm) hypothetical protein 0.0058 0.0589 0.1339
Leishmania major DNA polymerase eta, putative 0.0044 0.0414 0.0901
Toxoplasma gondii hypothetical protein 0.0048 0.0462 0.7362
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.0882 0.0789
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0675 0.0581
Brugia malayi phosphofructokinase 0.0106 0.12 0.2728
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0317 0.0219
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0309 0.2675
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1025 0.2151
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0224 1
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.0882 0.2004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0224 0.0288
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0333 0.0235
Entamoeba histolytica Ras family GTPase 0.036 0.44 1
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.12 0.2559
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.182 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0548 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1025 0.2151
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1074 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1025 0.2151
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0224 0.1339
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0224 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0675 0.1652
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1622 0.449
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1038 0.0947
Brugia malayi jmjC domain containing protein 0.0093 0.1038 0.2359
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.0882 0.0789
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1025 0.2151
Echinococcus multilocularis microtubule associated protein 2 0.0805 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0478 0.1086
Trichomonas vaginalis ras-dva small GTPase, putative 0.036 0.44 1
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.12 0.1111
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.01 0.0207
Echinococcus granulosus tumor protein p63 0.0394 0.4826 0.4774
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1025 0.0949
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.12 0.2728
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1025 0.2151
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0224 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1025 0.233
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0603 0.1371
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.12 0.3162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0628 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0309 0.0227
Trichomonas vaginalis rap1 and, putative 0.036 0.44 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0309 0.0211
Trypanosoma brucei polo-like protein kinase 0.0092 0.1025 0.2811
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0385 0.0819
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0297 0.0199
Schistosoma mansoni cpg binding protein 0.0028 0.0216 0.0133
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1025 0.0934
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0675 0.1825
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1025 0.2659
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0383 0.0285
Loa Loa (eye worm) hypothetical protein 0.0051 0.05 0.1135
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0317 0.0235
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.12 0.2559
Schistosoma mansoni hypothetical protein 0.0081 0.0882 0.0805
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0221 0.7155
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.12 0.1126
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.12 0.2559
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0385 0.101
Loa Loa (eye worm) phosphofructokinase 0.0106 0.12 0.2728
Brugia malayi hypothetical protein 0.0176 0.2082 0.4733
Loa Loa (eye worm) Ras protein let-60 0.036 0.44 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0362 0.0264
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.05 0.1148
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0224 0.0288
Loa Loa (eye worm) hypothetical protein 0.0081 0.0882 0.2004
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.0882 0.2004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0224 1
Trichomonas vaginalis set domain proteins, putative 0.0277 0.335 0.7559
Schistosoma mansoni hypothetical protein 0.004 0.0364 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0309 0.0227
Loa Loa (eye worm) hypothetical protein 0.0035 0.0309 0.0702
Brugia malayi 6-phosphofructokinase 0.0106 0.12 0.2728
Brugia malayi jmjC domain containing protein 0.0036 0.0317 0.0721
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0317 0.0721
Echinococcus granulosus expressed conserved protein 0.009 0.1001 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Brugia malayi Pre-SET motif family protein 0.0243 0.2928 0.6654
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0224 0.0288
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0675 0.1534
Plasmodium vivax SET domain protein, putative 0.0035 0.0309 1
Giardia lamblia Kinase, PLK 0.0092 0.1025 1
Echinococcus granulosus dnaJ subfamily B 0.04 0.4896 0.4845
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0221 0.0139
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1025 0.0934
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0224 0.008
Schistosoma mansoni hypothetical protein 0.0028 0.0221 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0207
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.12 0.2559
Mycobacterium ulcerans hypothetical protein 0.0155 0.182 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0221 0.0123
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.01 0.0207
Loa Loa (eye worm) hypothetical protein 0.0176 0.2082 0.4733
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0224 0.0288
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.9842 0.984
Trichomonas vaginalis ral, putative 0.036 0.44 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.12 0.2559
Schistosoma mansoni patched 1 0.0041 0.0383 0.0301

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 228 uM Inhibitory activity of compound against Dipeptidyl-peptidase II (DPP II) ChEMBL. 14584950
IC50 (binding) = 228 uM Inhibitory activity of compound against Dipeptidyl-peptidase II (DPP II) ChEMBL. 14584950
IC50 (binding) = 374 uM Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) ChEMBL. 14584950
IC50 (binding) = 374 uM Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) ChEMBL. 14584950
Selectivity index (binding) = 2 Selectivity index of compound was determined as value for DPP IV divided by value for DPP II ChEMBL. 14584950

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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