Detailed information for compound 254258

Basic information

Technical information
  • TDR Targets ID: 254258
  • Name: 4-methoxy-2,3-dihydro-1H-inden-1-amine
  • MW: 163.216 | Formula: C10H13NO
  • H donors: 1 H acceptors: 0 LogP: 1.18 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1CCC2N
  • InChi: 1S/C10H13NO/c1-12-10-4-2-3-7-8(10)5-6-9(7)11/h2-4,9H,5-6,11H2,1H3
  • InChiKey: JMXMRMSUOHVHOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methoxyindan-1-amine
  • 4-methoxy-1-indanamine
  • (4-methoxyindan-1-yl)amine
  • 52372-96-0
  • 2,3-Dihydro-4-methoxy-1H-inden-1-amine
  • 1H-Inden-1-amine, 2,3-dihydro-4-methoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0049 0.0086 0.1742
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0009 0.0076
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0009 0.0045
Onchocerca volvulus 0.0013 0.0009 0.0497
Loa Loa (eye worm) MH2 domain-containing protein 0.0093 0.0178 0.3624
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0009 0.2225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0058 0.052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0058 0.0416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0018 0.002 0.328
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0013 0.0009 0.0116
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0138 0.0274 0.5571
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0163 0.0155
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0089 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0013 0.0009 0.019
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0086 0.0764
Echinococcus granulosus Protein Wnt-04 0.0011 0.0003 0.0031
Loa Loa (eye worm) TAR-binding protein 0.0049 0.0086 0.1742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0058 0.052
Echinococcus multilocularis cysteine protease 0.0013 0.0009 0.0045
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0018 0.002 0.0011
Plasmodium vivax vivapain-2 0.0013 0.0009 0.0116
Leishmania major trypanothione reductase 0.0038 0.0061 0.6518
Echinococcus multilocularis inositol monophosphatase 1 0.0029 0.0042 0.0293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0058 0.052
Loa Loa (eye worm) ctsf protein 0.0013 0.0009 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0266 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0009 0.0352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0632 0.1319 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0163 0.0155
Brugia malayi wnt family protein 0.0011 0.0003 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0163 0.0293
Leishmania major cathepsin L-like protease 0.0051 0.0089 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0001 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.007
Echinococcus granulosus cathepsin L cysteine proteinase 0.0013 0.0009 0.0083
Brugia malayi Thioredoxin reductase 0.0038 0.0061 0.124
Schistosoma mansoni microtubule-associated protein tau 0.0538 0.1119 1
Echinococcus granulosus Protein Wnt-5 0.0011 0.0003 0.0031
Plasmodium vivax glutathione reductase, putative 0.0038 0.0061 1
Echinococcus granulosus cathepsin l1 0.0013 0.0009 0.0083
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0009 0.0329
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0026 0.0036 0.0033
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0163 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0036 0.0058 0.1185
Echinococcus granulosus Protein Wnt-111 0.0011 0.0003 0.0031
Onchocerca volvulus 0.0013 0.0009 0.0497
Onchocerca volvulus Cathepsin F homolog 0.0013 0.0009 0.0497
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0009 0.0497
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0009 0.0078
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0029 0.0042 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Leishmania major cathepsin L-like protease 0.0013 0.0009 0.0076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0061 0.0052
Onchocerca volvulus 0.0013 0.0009 0.0497
Brugia malayi RNA recognition motif domain containing protein 0.0049 0.0086 0.1742
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0042 0.1581
Echinococcus granulosus inositol monophosphatase 1 0.0029 0.0042 0.0375
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0018 0.002 0.2092
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0013 0.0009 0.0116
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0018 0.002 0.0011
Brugia malayi wnt family protein 0.0011 0.0003 0.007
Schistosoma mansoni wnt related 0.0011 0.0003 0.0031
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0089 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0029 0.0042 1
Schistosoma mansoni hypothetical protein 0.0132 0.0261 0.2328
Plasmodium vivax vivapain-2 0.0013 0.0009 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0009 0.0329
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0009 0.0497
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0042 0.1581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Loa Loa (eye worm) hypothetical protein 0.0098 0.0188 0.3825
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0042 0.4157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.007
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0061 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Loa Loa (eye worm) cysteine protease 0.0013 0.0009 0.019
Leishmania major cathepsin L-like protease 0.0013 0.0009 0.0076
Brugia malayi Wnt-2 protein precursor 0.0011 0.0003 0.007
Echinococcus multilocularis geminin 0.0132 0.0261 0.1955
Leishmania major cathepsin L-like protease 0.0013 0.0009 0.0076
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0018 0.002 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0058 0.0416
Loa Loa (eye worm) Wnt2 protein 0.0011 0.0003 0.007
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0018 0.002 0.0011
Entamoeba histolytica cysteine protease, putative 0.0013 0.0009 0.2225
Plasmodium falciparum thioredoxin reductase 0.0038 0.0061 1
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0089 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0061 0.124
Brugia malayi Zinc finger, C2H2 type family protein 0.0241 0.0491 1
Loa Loa (eye worm) wnt-4 protein 0.0011 0.0003 0.007
Leishmania major cathepsin L-like protease 0.0051 0.0089 1
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.002 0.1363
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0183 0.0175
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0061 0.0544
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.2336 0.4922 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0047 0.0079 0.8832
Schistosoma mansoni inositol monophosphatase 0.0029 0.0042 0.0375
Echinococcus granulosus tar DNA binding protein 0.0049 0.0086 0.0764
Onchocerca volvulus 0.0065 0.0118 0.6292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.007
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0026 0.0036 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Toxoplasma gondii thioredoxin reductase 0.0038 0.0061 1
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0086 0.0764
Trypanosoma cruzi major cysteine proteinase, putative 0.004 0.0066 0.712
Leishmania major phosphopantetheinyl transferase-like protein 0.0018 0.002 0.1363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Mycobacterium tuberculosis Probable reductase 0.0086 0.0163 0.0155
Loa Loa (eye worm) hypothetical protein 0.0138 0.0274 0.5571
Echinococcus granulosus L aminoadipate semialdehyde 0.0065 0.0118 0.1056
Onchocerca volvulus Huntingtin homolog 0.0098 0.0188 1
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0009 0.019
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0042 0.4157
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0061 0.6518
Brugia malayi Cathepsin L-like precursor 0.0013 0.0009 0.019
Onchocerca volvulus 0.0013 0.0009 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0086 0.0764
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0018 0.002 1
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0009 0.0083
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0009 0.0083
Schistosoma mansoni wnt-5 0.0011 0.0003 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0009 0.0352
Brugia malayi wnt family protein 0.0011 0.0003 0.007
Schistosoma mansoni wnt related 0.0011 0.0003 0.0031
Toxoplasma gondii cathepsin CPL 0.0013 0.0009 0.0116
Echinococcus multilocularis L aminoadipate semialdehyde 0.0065 0.0118 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0061 1
Leishmania major cathepsin L-like protease 0.0013 0.0009 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0058 0.052
Onchocerca volvulus 0.0013 0.0009 0.0497
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0009 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0089 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0163 0.0155
Brugia malayi Cathepsin L-like precursor 0.0013 0.0009 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0036 0.0058 0.1185
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0009 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Plasmodium falciparum glutathione reductase 0.0038 0.0061 1
Echinococcus granulosus geminin 0.0132 0.0261 0.2328
Echinococcus multilocularis zinc finger transcription factor gli2 0.0241 0.0491 0.3708
Echinococcus multilocularis tar DNA binding protein 0.0049 0.0086 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0058 0.052
Echinococcus multilocularis cysteine protease 0.0013 0.0009 0.0045
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0009 0.0045
Brugia malayi TAR-binding protein 0.0049 0.0086 0.1742
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0009 0.019
Brugia malayi hypothetical protein 0.0098 0.0188 0.3825
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0049 0.0086 0.1742
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0065 0.0118 0.1056
Loa Loa (eye worm) transcription factor SMAD2 0.0093 0.0178 0.3624
Loa Loa (eye worm) fibroinase 0.0013 0.0009 0.019
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0086 0.0764
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0183 0.0334
Brugia malayi RNA binding protein 0.0049 0.0086 0.1742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0042 0.4157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Onchocerca volvulus 0.0013 0.0009 0.0497
Schistosoma mansoni hypothetical protein 0.0132 0.0261 0.2328
Schistosoma mansoni wnt related 0.0011 0.0003 0.0031
Brugia malayi Cathepsin L-like precursor 0.0013 0.0009 0.019
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0001 0.0028
Trypanosoma brucei trypanothione reductase 0.0038 0.0061 0.6518
Leishmania major cathepsin L-like protease 0.0013 0.0009 0.0076
Brugia malayi MH2 domain containing protein 0.0093 0.0178 0.3624
Loa Loa (eye worm) hypothetical protein 0.0065 0.0118 0.2407
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0009 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Loa Loa (eye worm) zinc finger protein 0.0241 0.0491 1
Onchocerca volvulus 0.0013 0.0009 0.0497
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0065 0.0118 0.2407
Brugia malayi glutathione reductase 0.0038 0.0061 0.124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.007
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0086 0.0764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Loa Loa (eye worm) CWN-2 protein 0.0011 0.0003 0.007
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0029 0.0042 0.0033
Brugia malayi Inositol-1 0.0029 0.0042 0.0855
Loa Loa (eye worm) hypothetical protein 0.0098 0.0188 0.3825
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0009 0.2225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0042 0.4157
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0183 0.0175
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0009 0.0078
Brugia malayi Cathepsin L-like precursor 0.0013 0.0009 0.019
Leishmania major cysteine peptidase A (CPA) 0.0013 0.0009 0.0076
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0018 0.002 0.2092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Onchocerca volvulus Huntingtin homolog 0.0098 0.0188 1
Schistosoma mansoni inositol monophosphatase 0.0029 0.0042 0.0375
Schistosoma mansoni wnt related 0.0011 0.0003 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Brugia malayi Cathepsin L-like precursor 0.0013 0.0009 0.019
Brugia malayi Wnt-4 protein precursor 0.0011 0.0003 0.007
Brugia malayi wnt family protein 0.0011 0.0003 0.007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0009 0.0045
Loa Loa (eye worm) inositol-1 0.0029 0.0042 0.0855
Brugia malayi Cathepsin L-like precursor 0.0013 0.0009 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0163 0.0155
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0029 0.0042 0.6377
Trichomonas vaginalis inositol monophosphatase, putative 0.0029 0.0042 0.1581
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0183 0.0175
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0089 1
Echinococcus granulosus protein Wnt 2 0.0011 0.0003 0.0031
Echinococcus multilocularis microtubule associated protein 2 0.0538 0.1119 0.8485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0009 0.0352
Echinococcus granulosus protein Wnt 1 0.0011 0.0003 0.0031
Echinococcus granulosus microtubule associated protein 2 0.0538 0.1119 1
Leishmania major cathepsin L-like protease 0.0051 0.0089 1
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.4737 1 1
Echinococcus granulosus Protein Wnt-11b 0.0011 0.0003 0.0031
Plasmodium falciparum cysteine proteinase falcipain 3 0.0013 0.0009 0.0116
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0018 0.002 0.2092
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0061 0.124
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0009 0.004
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0018 0.002 0.2092
Echinococcus granulosus zinc finger transcription factor gli2 0.0241 0.0491 0.4388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0009 0.0352
Entamoeba histolytica hypothetical protein 0.0018 0.002 0.4678
Echinococcus granulosus cathepsin l cysteine peptidase 0.0013 0.0009 0.0083

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0 Inhibition of Monoamine oxidase (MAO); Inactive ChEMBL. 3959029

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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