Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0115 | 0.4002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0611 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.0107 | 0.362 | 0.5 |
Plasmodium falciparum | MO15-related protein kinase | 0.0115 | 0.4002 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.0611 | 0.5 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0611 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0611 | 0.0611 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative Kd (binding) | = 31 | Mouse ribonucleotide reductase (mRR) activity was determined by relative dissociation constant which was assayed for binding activity to mR1 | ChEMBL. | 11844661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.