TDR Targets

Basic information

Technical information

TDR Targets ID: 256266
Name: 5-[1-(3-carboxy-5-chloro-4-hydroxyphenyl)-4-[ hydroxy-[(9Z,12Z)-octadeca-9,12-dienoxy]phosp horyl]oxybut-1-enyl]-3-chloro-2-hydroxybenzoi c acid
MW: 741.632 | Formula: C36H47Cl2O10P
H donors: 5 H acceptors: 8 LogP: 11.38 Rotable bonds: 24
Rule of 5 violations (Lipinski): 2
SMILES: CCCCC/C=C\C/C=C\CCCCCCCCOP(=O)(OCCC=C(c1cc(Cl)c(c(c1)C(=O)O)O)c1cc(Cl)c(c(c1)C(=O)O)O)O
InChi: 1S/C36H47Cl2O10P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-47-49(45,46)48-21-18-19-28(26-22-29(35(41)42)33(39)31(37)24-26)27-23-30(36(43)44)34(40)32(38)25-27/h6-7,9-10,19,22-25,39-40H,2-5,8,11-18,20-21H2,1H3,(H,41,42)(H,43,44)(H,45,46)/b7-6-,10-9-
InChiKey: YTVOFJMAYQTFPX-HZJYTTRNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[1-(3-carboxy-5-chloro-4-hydroxy-phenyl)-4-[hydroxy-[(9Z,12Z)-octadeca-9,12-dienoxy]phosphoryl]oxy-but-1-enyl]-3-chloro-2-hydroxy-benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	fibroinase	0.0071	0.3757	0.3892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Trypanosoma brucei	ingi protein (ORF1)	0.0045	0.1773	0.1773
Trypanosoma cruzi	ribonuclease H1, putative	0.0041	0.1511	0.1565
Brugia malayi	Cathepsin L-like precursor	0.0049	0.2096	0.2172
Echinococcus granulosus	cathepsin l1	0.0071	0.3757	0.3892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.3757	0.3892
Schistosoma mansoni	cathepsin F (C01 family)	0.0071	0.3757	0.3757
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1812	0.1812
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.1321	0.3517
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0058	0.2751	0.285
Echinococcus granulosus	cathepsin l1	0.0049	0.2096	0.2172
Brugia malayi	cathepsin B-like cysteine proteinase	0.015	0.9653	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.015	0.9653	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2096	0.2172
Brugia malayi	Cathepsin L-like precursor	0.0071	0.3757	0.3892
Plasmodium vivax	vivapain-1	0.0039	0.1321	0.3517
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.015	0.9653	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0022	0.0085	0.0088
Onchocerca volvulus		0.0071	0.3757	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Trypanosoma brucei	RNA helicase, putative	0.0155	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1812	0.1812
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Giardia lamblia	Cathepsin B precursor	0.0058	0.2751	1
Plasmodium vivax	unspecified product	0.0022	0.0085	0.0226
Echinococcus multilocularis	cathepsin L	0.0039	0.1321	0.1369
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.1321	0.1369
Plasmodium vivax	vivapain-2	0.0071	0.3757	1
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.1321	0.3517
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Echinococcus multilocularis	ribonuclease H1	0.0041	0.1511	0.1565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Trypanosoma brucei	ribonuclease H1	0.0041	0.1511	0.1511
Giardia lamblia	Ribonuclease H	0.0041	0.1511	0.5493
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.3757	0.3892
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0085	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0071	0.3757	0.3892
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.3512	0.3638
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Giardia lamblia	Cathepsin B precursor	0.0058	0.2751	1
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0045	0.1773	0.1773
Echinococcus multilocularis	cysteine protease	0.0071	0.3757	0.3892
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1812	0.1812
Echinococcus granulosus	ribonuclease H1	0.0041	0.1511	0.1565
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.1321	0.3517
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Onchocerca volvulus		0.0071	0.3757	1
Brugia malayi	Cathepsin L-like precursor	0.0049	0.2096	0.2172
Brugia malayi	Cathepsin L-like precursor	0.0071	0.3757	0.3892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Plasmodium vivax	unspecified product	0.0039	0.1321	0.3517
Brugia malayi	Cathepsin L-like precursor	0.0071	0.3757	0.3892
Entamoeba histolytica	cysteine protease, putative	0.0071	0.3757	1
Entamoeba histolytica	cysteine proteinase, putative	0.0071	0.3757	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Brugia malayi	RNase H family protein	0.0041	0.1511	0.1565
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Onchocerca volvulus		0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0071	0.3757	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.1321	0.1321
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0039	0.1321	0.1321
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Echinococcus multilocularis	cathepsin L cysteine protease	0.0071	0.3757	0.3892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.2096	0.5579
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0058	0.2751	0.2751
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0058	0.2751	0.7321
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.0085	0.0088
Onchocerca volvulus		0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Brugia malayi	Papain family cysteine protease containing protein	0.0071	0.3757	0.3892
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Loa Loa (eye worm)	cathepsin B	0.0058	0.2751	0.285
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0085	0.0088
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.1321	0.1369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.1321	0.3517
Schistosoma mansoni	cathepsin s	0.0022	0.0085	0.0085
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2096	0.2172
Toxoplasma gondii	cathepsin B	0.0058	0.2751	0.7321
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.1321	0.1369
Echinococcus granulosus	cysteine protease	0.0039	0.1321	0.1369
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.3512	0.3512
Entamoeba histolytica	cysteine proteinase, putative	0.0071	0.3757	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0071	0.3757	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.3512	1
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.3757	0.3892
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Schistosoma mansoni	cathepsin F (C01 family)	0.0071	0.3757	0.3757
Echinococcus multilocularis	cathepsin L cysteine protease	0.0071	0.3757	0.3892
Plasmodium vivax	vivapain-2	0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0071	0.3757	1
Loa Loa (eye worm)	ctsf protein	0.0071	0.3757	0.3892
Trypanosoma cruzi	ribonuclease H1, putative	0.0041	0.1511	0.1565
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0041	0.1511	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Treponema pallidum	ribonuclease H (rnhA)	0.0041	0.1511	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0088
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.2751	0.2751
Toxoplasma gondii	cathepsin CPL	0.0071	0.3757	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0088
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0039	0.1321	0.1369
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.015	0.9653	0.9653
Onchocerca volvulus		0.0071	0.3757	1
Schistosoma mansoni	phosphoglucomutase	0.0041	0.1511	0.1511
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.1321	0.3517
Toxoplasma gondii	ribonuclease HI protein	0.0041	0.1511	0.4021
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Leishmania major	ribonuclease H1, putative	0.0041	0.1511	0.4021
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.015	0.9653	0.9653
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.2096	0.5579
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.015	0.9653	0.9653
Onchocerca volvulus		0.0071	0.3757	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0039	0.1321	0.1369
Echinococcus granulosus	cathepsin b	0.015	0.9653	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.2096	0.5579
Trypanosoma brucei	hypothetical protein, conserved	0.0045	0.1773	0.1773
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1812	0.1877
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Brugia malayi	Cathepsin L-like precursor	0.0071	0.3757	0.3892
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0058	0.2751	0.7321
Echinococcus multilocularis	cathepsin b	0.015	0.9653	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Echinococcus multilocularis	cysteine protease	0.0071	0.3757	0.3892
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0039	0.1321	0.1321
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0085	0.0088
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.3757	0.3892
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1812	0.1877
Brugia malayi	Cathepsin L-like precursor	0.0071	0.3757	0.3892
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Schistosoma mansoni	phosphoglucomutase	0.0041	0.1511	0.1511
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Onchocerca volvulus	Cathepsin F homolog	0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Plasmodium vivax	vivapain-3	0.0039	0.1321	0.3517
Onchocerca volvulus		0.0049	0.2096	0.2606
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0071	0.3757	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1812	0.1877
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.3512	0.9347
Echinococcus granulosus	cathepsin L	0.0039	0.1321	0.1369
Leishmania major	cysteine peptidase A (CPA)	0.0071	0.3757	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.3512	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.3512	0.9347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2096	0.2172
Entamoeba histolytica	cysteine proteinase 1, putative	0.0039	0.1321	0.3517
Onchocerca volvulus		0.0071	0.3757	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.3512	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0049	0.2096	0.2172
Brugia malayi	cathepsin L-like precursor	0.0049	0.2096	0.2172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0071	0.3757	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0039	0.1321	0.3517
Onchocerca volvulus	Cathepsin L homolog	0.0071	0.3757	1
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.1321	0.1369
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.3512	0.3638
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0071	0.3757	0.3892
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0088
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Entamoeba histolytica	cysteine proteinase 2	0.0039	0.1321	0.3517
Schistosoma mansoni	phosphoglucomutase	0.0041	0.1511	0.1511
Brugia malayi	Cathepsin L-like precursor	0.0071	0.3757	0.3892
Echinococcus multilocularis	cathepsin b	0.015	0.9653	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0039	0.1321	0.1369
Brugia malayi	RNase H family protein	0.0041	0.1511	0.1565
Giardia lamblia	Cathepsin B precursor	0.0058	0.2751	1
Trypanosoma brucei	unspecified product	0.0045	0.1773	0.1773
Entamoeba histolytica	cysteine protease, putative	0.0039	0.1321	0.3517
Trypanosoma cruzi	cysteine protease, putative	0.0039	0.1321	0.1369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.1321	0.1321
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0071	0.3757	0.3892
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.1321	0.3517
Onchocerca volvulus	Cathepsin L homolog	0.0071	0.3757	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.3757	0.3892
Trypanosoma cruzi	cruzipain precursor, putative	0.0071	0.3757	0.3892
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.3757	0.3757
Brugia malayi	RNase H family protein	0.0041	0.1511	0.1565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Trypanosoma brucei	ingi protein (ORF1)	0.0045	0.1773	0.1773
Loa Loa (eye worm)	hypothetical protein	0.015	0.9653	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1812	0.1877
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1812	0.1877
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.1321	0.1321
Brugia malayi	cathepsin F-like cysteine proteinase	0.0022	0.0085	0.0088
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0071	0.3757	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1812	0.1877
Loa Loa (eye worm)	cysteine protease	0.0071	0.3757	0.3892
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.2096	0.2096
Leishmania major	cathepsin L-like protease	0.0071	0.3757	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0071	0.3757	0.3892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0071	0.3757	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.3512	0.3512
Trichomonas vaginalis	ribonuclease H1, putative	0.0041	0.1511	0.4021
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0071	0.3757	0.3892
Echinococcus granulosus	cathepsin b	0.015	0.9653	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0071	0.3757	0.3892
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.3512	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0049	0.2096	0.2172

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 51.8 uM	Effective concentration of the compound against HIV-1RF induced cytopathicity in CEM-SS cells	ChEMBL.	8558520
EC50 (functional)	= 51.8 uM	Effective concentration of the compound against HIV-1RF induced cytopathicity in CEM-SS cells	ChEMBL.	8558520
IC50 (functional)	= 86 uM	Cytotoxic concentration of the compound against mock-infected CEM-SS cells	ChEMBL.	8558520
IC50 (functional)	= 86 uM	Cytotoxic concentration of the compound against mock-infected CEM-SS cells	ChEMBL.	8558520

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11803123

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 256266