TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 306.443 | Formula: C18H30N2O2
H donors: 0 H acceptors: 1 LogP: 3.03 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOCCN(c1c(C)cccc1C)C(=O)CN(CC)CC
InChi: 1S/C18H30N2O2/c1-6-19(7-2)14-17(21)20(12-13-22-8-3)18-15(4)10-9-11-16(18)5/h9-11H,6-8,12-14H2,1-5H3
InChiKey: DYRGMUPZSJGPRT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0475	0.0668	0.066
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0142	0.2127
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0013	0.0008	0.0123
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0013	0.0008	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0138	0.2066
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0072	0.0093	0.1391
Plasmodium vivax	protein kinase Crk2	0.0052	0.0064	0.0056
Echinococcus granulosus	cyclins	0.0017	0.0014	0.0216
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0475	0.0668	0.066
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0052	0.0064	0.0958
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0475	0.0668	1
Echinococcus multilocularis	cyclins	0.0017	0.0014	0.0216
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.7007	1	1
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.7007	1	1
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.7007	1	1
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0106	0.0141	0.2012
Loa Loa (eye worm)	RNA binding protein	0.0063	0.008	0.1193
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0017	0.0014	0.0094
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.0299	0.0417	0.6241
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0064	0.0846
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Mycobacterium tuberculosis	Probable oxidoreductase	0.0475	0.0668	0.066
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0064	0.0958
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0475	0.0668	0.066
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0417	0.6241
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.7007	1	1
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.0299	0.0417	0.6241
Loa Loa (eye worm)	oxidoreductase	0.0475	0.0668	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.7007	1	1
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0475	0.0668	1
Trypanosoma brucei	oxidoreductase-like protein	0.0475	0.0668	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0014	0.0216
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0107	0.0142	0.2127
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0064	0.0759
Schistosoma mansoni	cyclin B	0.0017	0.0014	0.0216
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0475	0.0668	0.066
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0475	0.0668	0.066
Echinococcus multilocularis	cyclins	0.0017	0.0014	0.0216
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0093	0.1391
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0475	0.0668	1
Brugia malayi	Amidase family protein	0.0013	0.0008	0.0123
Plasmodium falciparum	protein kinase 5	0.0052	0.0064	0.0056
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0064	0.0958
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0195	0.2927
Plasmodium vivax	serine/threonine kinase-1, putative	0.0072	0.0093	0.0085
Onchocerca volvulus		0.0475	0.0668	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0045	0.0037
Echinococcus multilocularis	cyclins	0.0017	0.0014	0.0216
Trypanosoma brucei	cdc2-related kinase 3	0.0052	0.0064	0.0846
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0014	0.0216
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0072	0.0093	0.1284
Echinococcus granulosus	cyclin dependent kinase	0.0052	0.0064	0.0958
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0106	0.0141	0.2012
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.005	0.0042
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0052	0.0064	0.0958
Echinococcus multilocularis	cyclin dependent kinase 5	0.0052	0.0064	0.0958
Trypanosoma cruzi	cyclin, putative	0.0017	0.0014	0.0094
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Loa Loa (eye worm)	cyclin domain-containing protein	0.0017	0.0014	0.0216
Echinococcus multilocularis	cyclins	0.0017	0.0014	0.0216
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.005	0.0042
Brugia malayi	hypothetical protein	0.0143	0.0194	0.2908
Schistosoma mansoni	fatty-acid amide hydrolase	0.0013	0.0008	0.0123
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0475	0.0668	1
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0072	0.0093	0.1391
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Echinococcus multilocularis	cyclin B	0.0017	0.0014	0.0216
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0475	0.0668	1
Leishmania major	pteridine reductase 1	0.0475	0.0668	1
Trichomonas vaginalis	hypothetical protein	0.7007	1	1
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0013	0.0008	0.0123
Giardia lamblia	Kinase, CMGC CLK	0.0072	0.0093	1
Echinococcus granulosus	dual specificity protein kinase clk2	0.0072	0.0093	0.1391
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0072	0.0093	0.1284
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0064	0.0958
Brugia malayi	putative amidase	0.0013	0.0008	0.0123
Echinococcus granulosus	tar DNA binding protein	0.0063	0.008	0.1193
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.7007	1	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0064	0.0958
Mycobacterium tuberculosis	Possible oxidoreductase	0.0475	0.0668	0.066
Mycobacterium ulcerans	oxidoreductase	0.0475	0.0668	0.066
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Echinococcus granulosus	hypothetical protein	0.007	0.009	0.1347
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0017	0.0014	0.0216
Onchocerca volvulus		0.0475	0.0668	1
Echinococcus granulosus	cyclin B	0.0017	0.0014	0.0216
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0475	0.0668	1
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0475	0.0668	1
Schistosoma mansoni	cyclins	0.0017	0.0014	0.0216
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.008	0.1193
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0475	0.0668	0.066
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0017	0.0014	0.0216
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0064	0.0846
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Schistosoma mansoni	dihydropteridine reductase	0.0475	0.0668	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Leishmania major	oxidoreductase-like protein	0.0475	0.0668	1
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0475	0.0668	0.066
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.005	0.0036
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0064	0.6317
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0475	0.0668	0.066
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.019	0.284
Schistosoma mansoni	cyclin B3	0.0017	0.0014	0.0216
Schistosoma mansoni	serine/threonine protein kinase	0.0106	0.0141	0.211
Echinococcus granulosus	cyclins	0.0017	0.0014	0.0216
Echinococcus multilocularis	ankyrin repeat protein	0.0325	0.0454	0.6806
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0064	0.0958
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0106	0.0141	0.2012
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0475	0.0668	1
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0093	0.1391
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0107	0.0142	0.2127
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0064	0.0958
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0072	0.0093	0.1284
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0013	0.0008	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Echinococcus granulosus	cyclins	0.0017	0.0014	0.0216
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0216
Echinococcus multilocularis	calcium activated potassium channel	0.0009	0.0002	0.0033
Leishmania major	protein kinase, putative	0.0072	0.0093	0.1284
Echinococcus granulosus	cyclin b3	0.0017	0.0014	0.0216
Echinococcus multilocularis	cyclins	0.0017	0.0014	0.0216
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0475	0.0668	0.066
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0072	0.0093	0.1284
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Brugia malayi	Protein kinase domain containing protein	0.0106	0.0141	0.211
Echinococcus granulosus	cyclin dependent kinase 5	0.0052	0.0064	0.0958
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Echinococcus multilocularis	cyclin b3	0.0017	0.0014	0.0216
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0106	0.0141	0.211
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.005	0.0753
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0475	0.0668	0.066
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.008	0.1193
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0475	0.0668	1
Echinococcus granulosus	cyclin dependent kinase 1	0.0052	0.0064	0.0958
Echinococcus multilocularis	transient receptor potential cation channel	0.0007	0.0000000097456	0.00000014595
Plasmodium falciparum	protein serine/threonine kinase-1	0.0072	0.0093	0.0085
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0072	0.0093	0.1284
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0475	0.0668	1
Echinococcus multilocularis		0.007	0.009	0.1347
Entamoeba histolytica	hypothetical protein	0.0106	0.0141	0.1936
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0064	0.005
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0475	0.0668	0.066
Echinococcus granulosus	transient receptor potential cation channel	0.0007	0.0000000097456	0.00000014595
Trypanosoma cruzi	cyclin 6, putative	0.0017	0.0014	0.0094
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0195	0.2927
Loa Loa (eye worm)	hypothetical protein	0.0475	0.0668	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0064	0.0846
Echinococcus multilocularis	cyclin dependent kinase	0.0052	0.0064	0.0958
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.008	0.1193
Brugia malayi	cell division control protein 2 homolog	0.0052	0.0064	0.0958
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0195	0.2927
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0475	0.0668	0.066
Schistosoma mansoni	fatty-acid amide hydrolase	0.0107	0.0142	0.2127
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0475	0.0668	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.005	0.0042
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0475	0.0668	0.066
Loa Loa (eye worm)	hypothetical protein	0.007	0.009	0.1347
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0106	0.0141	0.2012
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0072	0.0093	0.1284
Echinococcus granulosus	cyclin B3 1	0.0017	0.0014	0.0216
Plasmodium falciparum	cyclin	0.0017	0.0014	0.0006
Echinococcus multilocularis	transient receptor potential cation channel	0.0332	0.0465	0.6958
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.008	0.1193
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0013	0.0008	0.0123
Loa Loa (eye worm)	amidase	0.0013	0.0008	0.0123
Echinococcus multilocularis	cyclins	0.0017	0.0014	0.0216
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0045	0.393
Chlamydia trachomatis	oxoacy-ACP reductase	0.0475	0.0668	0.066
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0475	0.0668	0.066
Plasmodium falciparum	enoyl-acyl carrier reductase	0.7007	1	1
Schistosoma mansoni	amidase	0.0107	0.0142	0.2127
Echinococcus multilocularis	cyclin B3 1	0.0017	0.0014	0.0216
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0107	0.0142	0.2127
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0017	0.0014	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0216
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Echinococcus granulosus	cyclins	0.0017	0.0014	0.0216
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.008	0.1193
Trypanosoma brucei	cdc2-related kinase 1	0.0052	0.0064	0.0846
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0475	0.0668	0.066
Echinococcus granulosus	cyclins	0.0017	0.0014	0.0216
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0052	0.0064	0.0056
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0475	0.0668	0.066
Leishmania major	protein kinase, putative	0.0072	0.0093	0.1284
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0014	0.0216
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0064	0.005
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0194	0.2908
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0475	0.0668	0.066
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0052	0.0064	0.0846
Echinococcus granulosus	ankyrin repeat protein	0.0325	0.0454	0.6806
Entamoeba histolytica	protein kinase domain containing protein	0.0106	0.0141	0.1936
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0475	0.0668	1
Echinococcus multilocularis	dual specificity	0.0106	0.0141	0.211
Brugia malayi	TAR-binding protein	0.0063	0.008	0.1193
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0093	0.1391
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.008	0.1193
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0052	0.0064	0.0846
Mycobacterium tuberculosis	Possible oxidoreductase	0.0475	0.0668	0.066
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.008	0.1193
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Mycobacterium ulcerans	short chain dehydrogenase	0.0475	0.0668	0.066
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0325	0.0454	0.6806
Echinococcus multilocularis	cyclins	0.0017	0.0014	0.0216
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0045	0.0472
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0064	0.6317
Entamoeba histolytica	protein kinase, putative	0.0106	0.0141	0.1936
Brugia malayi	RNA binding protein	0.0063	0.008	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0138	0.2066
Brugia malayi	Amidase family protein	0.0013	0.0008	0.0123
Brugia malayi	amidase	0.0107	0.0142	0.2127
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0475	0.0668	0.066
Trichomonas vaginalis	CMGC family protein kinase	0.0072	0.0093	0.0079
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0475	0.0668	1
Echinococcus granulosus	calcium activated potassium channel	0.0009	0.0002	0.0033
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0475	0.0668	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.008	0.1193
Trypanosoma cruzi	cyclin, putative	0.0017	0.0014	0.0094
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0064	0.0846
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0064	0.0759
Loa Loa (eye worm)	hypothetical protein	0.005	0.0061	0.0914
Trypanosoma brucei	mitotic cyclin 6	0.0017	0.0014	0.0094
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.008	0.1193
Echinococcus granulosus	dual specificity	0.0106	0.0141	0.211
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0064	0.005
Loa Loa (eye worm)	amidase	0.0013	0.0008	0.0123
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0475	0.0668	0.066
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0195	0.2927
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0013	0.0008	0.0123
Echinococcus granulosus	cyclin dependent kinase 5 activator 1	0.0299	0.0417	0.6241
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.005	0.0036
Echinococcus granulosus	transient receptor potential cation channel	0.0332	0.0464	0.6948
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0064	0.0958
Trypanosoma brucei	pteridine reductase 1	0.0475	0.0668	1
Leishmania major	cyclin	0.0017	0.0014	0.0094
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0475	0.0668	0.066
Entamoeba histolytica	protein kinase, putative	0.0106	0.0141	0.1936
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0072	0.0093	0.0084
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0107	0.0142	0.2127
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0475	0.0668	1
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0475	0.0668	0.066
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0194	0.2908

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 0.06 mM kg-1	Antiarrhythmic activity of the compound was tested against arrhythmogenic effects of chloroform in mice after sc administration.	ChEMBL.	7205876
ED50 (functional)	= 0.06 mM kg-1	Antiarrhythmic activity of the compound was tested against arrhythmogenic effects of chloroform in mice after sc administration.	ChEMBL.	7205876
ED50 (functional)	= 0.08 mM kg-1	Acute CNS toxicity of the compound was tested against arrhythmogenic effects of chloroform in mice after sc administration.	ChEMBL.	7205876
ED50 (functional)	= 0.08 mM kg-1	Acute CNS toxicity of the compound was tested against arrhythmogenic effects of chloroform in mice after sc administration.	ChEMBL.	7205876
Therapeutic index (ADMET)	= 1.3	Therapeutic index is defined as the ratio of ED50(ataxia)/ED50(protection)	ChEMBL.	7205876

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL152877

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 263582