Detailed information for compound 263621

Basic information

Technical information
  • TDR Targets ID: 263621
  • Name: (E)-4-anilino-4-oxobut-2-enoic acid
  • MW: 191.183 | Formula: C10H9NO3
  • H donors: 2 H acceptors: 3 LogP: 0.87 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)/C=C/C(=O)O
  • InChi: 1S/C10H9NO3/c12-9(6-7-10(13)14)11-8-4-2-1-3-5-8/h1-7H,(H,11,12)(H,13,14)/b7-6+
  • InChiKey: WHZLCOICKHIPRL-VOTSOKGWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-4-anilino-4-oxo-but-2-enoic acid
  • (E)-4-anilino-4-oxo-2-butenoic acid
  • (E)-4-oxo-4-phenylazanyl-but-2-enoic acid
  • (E)-4-anilino-4-keto-but-2-enoic acid
  • maleic acid anilide
  • 4-oxo-4-(phenylamino)but-2-enoic acid
  • (E)-4-oxo-4-(phenylamino)but-2-enoic acid
  • (E)-4-keto-4-(phenylamino)but-2-enoic acid
  • 4-keto-4-(phenylamino)but-2-enoic acid
  • 37902-58-2
  • 4437-08-5
  • NSC163935
  • SR-01000645151-1
  • NSC 400304
  • 4-Anilino-4-oxo-2-butenoic acid
  • Fumaranilic acid
  • Maybridge4_003819
  • SBB003637
  • AIDS-160238
  • AIDS160238
  • 4-Oxo-4-(phenylamino)-2-butenoic acid
  • EINECS 253-707-3
  • NSC400304

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni opsin-like receptor 0.0074 0.0572 0.1203
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0198 0.2005 1
Brugia malayi N-myristoyltransferase 2 0.0198 0.2005 0.4303
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0307 0.3273 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0383 0.1135
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0068 0.0502 0.1101
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.0572 0.1203
Echinococcus granulosus g-protein coupled receptor 0.0074 0.0572 0.1203
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.02 0.2027 0.4351
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0572 0.1714
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0038
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0013 0.0028
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0572 0.1203
Echinococcus granulosus orexin receptor type 2 0.0074 0.0572 0.1203
Brugia malayi Choline O-acetyltransferase 0.0203 0.2072 0.4445
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0198 0.2005 0.4287
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0572 0.1714
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0307 0.3273 0.7015
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.0572 0.1203
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.039
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0013 0.0028
Echinococcus granulosus CREB binding protein 0.0069 0.051 0.1069
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.0572 0.1227
Onchocerca volvulus 0.0074 0.0572 1
Loa Loa (eye worm) hypothetical protein 0.0259 0.2713 0.8055
Loa Loa (eye worm) RNA binding protein 0.0066 0.0482 0.1431
Echinococcus granulosus allatostatin A receptor 0.0074 0.0572 0.1203
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Leishmania major carnitine palmitoyltransferase-like protein 0.0052 0.0316 0.1576
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Schistosoma mansoni amine GPCR 0.0074 0.0572 0.1203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Schistosoma mansoni lipoxygenase 0.0058 0.0383 0.0796
Echinococcus multilocularis allatostatin A receptor 0.0074 0.0572 0.1714
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.0572 0.1203
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.0572 0.1203
Onchocerca volvulus 0.0074 0.0572 1
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0052 0.0316 0.093
Echinococcus multilocularis serotonin receptor 0.0074 0.0572 0.1714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0013 0.0028
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0013 0.0028
Onchocerca volvulus 0.0052 0.0316 0.5529
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0013 0.0028
Mycobacterium tuberculosis Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) 0.0887 1 1
Brugia malayi Choline O-acetyltransferase 0.0203 0.2072 0.4445
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.0572 0.1203
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0572 0.1714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi steroid hormone receptor 0.0026 0.0013 0.0028
Onchocerca volvulus 0.0074 0.0572 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.0572 0.1697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0038
Brugia malayi RNA binding protein 0.0066 0.0482 0.1034
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0166 0.1635 0.8153
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0572 0.1714
Trichomonas vaginalis N-myristoyl transferase, putative 0.013 0.1219 0.5974
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.0572 0.1714
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0572 0.1203
Echinococcus granulosus neuropeptide receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0013 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0572 0.1203
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.0572 0.1714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0482 0.1009
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0572 0.1714
Brugia malayi TAZ zinc finger family protein 0.0427 0.466 1
Brugia malayi TAR-binding protein 0.0066 0.0482 0.1034
Onchocerca volvulus 0.0052 0.0316 0.5529
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0572 0.1203
Echinococcus granulosus neuropeptide s receptor 0.0074 0.0572 0.1203
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0427 0.466 1
Echinococcus granulosus CREB binding protein 0.0069 0.051 0.1069
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0315 0.3368 1
Schistosoma mansoni opsin-like receptor 0.0074 0.0572 0.1203
Onchocerca volvulus 0.0074 0.0572 1
Brugia malayi nuclear receptor NHR-88 0.0026 0.0013 0.0028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0482 0.1431
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0572 0.1714
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.0572 0.1203
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0052 0.0316 0.0678
Onchocerca volvulus 0.0074 0.0572 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0572 0.1203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Trypanosoma cruzi N-myristoyl transferase, putative 0.0198 0.2005 1
Schistosoma mansoni choline o-acyltransferase 0.0203 0.2072 0.443
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi follicle stimulating hormone receptor 0.0315 0.3368 0.7228
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus serotonin receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0572 0.1697
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0572 0.1203
Brugia malayi Dopamine receptor 0.0074 0.0572 0.1227
Leishmania major N-myristoyl transferase, putative 0.0198 0.2005 1
Trypanosoma brucei N-myristoyltransferase 0.0198 0.2005 1
Schistosoma mansoni myosin xvIII 0.0074 0.0572 0.1203
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0572 0.1203
Echinococcus multilocularis CREB binding protein 0.0295 0.3131 0.9564
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0198 0.2005 1
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0572 0.1714
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0013 0.0028
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.0572 0.1714
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0572 0.1203
Echinococcus granulosus histone acetyltransferase KAT2B 0.0105 0.0933 0.198
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0052 0.0316 0.0939
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus hypothetical protein 0.0074 0.0572 0.1203
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Schistosoma mansoni neuropeptide receptor 0.0074 0.0572 0.1203
Schistosoma mansoni hypothetical protein 0.0074 0.0572 0.1203
Schistosoma mansoni CREB-binding protein 2 0.0427 0.466 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.0572 0.1714
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.0572 0.1714
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0572 0.1714
Brugia malayi Serotonin receptor 0.0074 0.0572 0.1227
Brugia malayi G protein-coupled receptor 0.0074 0.0572 0.1227
Onchocerca volvulus 0.0074 0.0572 1
Brugia malayi larval opioid receptor 0.0074 0.0572 0.1227
Schistosoma mansoni histamine h1 receptor 0.0074 0.0572 0.1203
Brugia malayi neuropeptide F receptor 0.0074 0.0572 0.1227
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0038
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0198 0.2005 0.6111
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0572 0.1714
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0572 0.1714
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.02 0.2027 0.4335
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.0572 0.1714
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0572 0.1203
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0013 0.0224
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0105 0.0933 1
Brugia malayi ORL1-like opioid receptor 0.0074 0.0572 0.1227
Schistosoma mansoni amine GPCR 0.0074 0.0572 0.1203
Entamoeba histolytica acetyltransferase, GNAT family 0.0091 0.0767 0.3823
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0013 0.0028
Loa Loa (eye worm) CBP-B 0.0298 0.3173 0.9421
Onchocerca volvulus 0.0074 0.0572 1
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus multilocularis orexin receptor type 2 0.0074 0.0572 0.1714
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0572 0.1203
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0482 0.1009
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.0572 0.1227
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0572 0.1203
Echinococcus multilocularis CREB binding protein 0.0069 0.051 0.1524
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0572 0.1203
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0572 0.1714
Schistosoma mansoni neuropeptide receptor 0.0074 0.0572 0.1203
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus neuropeptide receptor 0.0074 0.0572 0.1203
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0572 0.1203
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.0572 0.1203
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0105 0.0933 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0482 0.1009
Echinococcus multilocularis choline O acetyltransferase 0.0203 0.2072 0.6314
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0052 0.0316 0.0678
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.0572 0.1227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.0572 0.1203
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.0572 0.1714
Brugia malayi neuropeptide F receptor 0.0074 0.0572 0.1227
Loa Loa (eye worm) hypothetical protein 0.0203 0.2072 0.615
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0068 0.0502 0.1053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0572 0.1714
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0572 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0013 0.0028
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0013 0.0224
Trichomonas vaginalis N-myristoyl transferase, putative 0.0198 0.2005 1
Onchocerca volvulus 0.0074 0.0572 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.0572 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0572 0.1203
Onchocerca volvulus 0.0052 0.0316 0.5529
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) acetyltransferase 0.0307 0.3273 0.9718
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0105 0.0933 0.2868
Schistosoma mansoni neuropeptide receptor 0.0074 0.0572 0.1203
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0068 0.0502 0.2504
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0572 0.1714
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.0572 0.1714
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus histone acetyltransferase KAT2B 0.0278 0.2934 0.6285
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.02 0.2027 0.4335
Brugia malayi GnHR receptor homolog 0.0074 0.0572 0.1227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.0572 0.1714
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0572 0.1203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Onchocerca volvulus 0.0074 0.0572 1
Schistosoma mansoni hypothetical protein 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0166 0.1635 0.7807
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.0572 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.0572 0.1697
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Loa Loa (eye worm) choline O-acetyltransferase 0.0203 0.2072 0.615
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi Melatonin receptor type 1A 0.0074 0.0572 0.1227
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0572 0.1714
Echinococcus granulosus g protein coupled receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Schistosoma mansoni opsin-like receptor 0.0074 0.0572 0.1203
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0166 0.1635 0.3508
Onchocerca volvulus 0.0074 0.0572 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.0572 0.1227
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.0572 0.1203
Leishmania major carnitine/choline acetyltransferase, putative 0.0052 0.0316 0.1576
Brugia malayi G-protein coupled receptor 0.0074 0.0572 0.1227
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.0572 0.1714
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0482 0.1439
Brugia malayi putative neuropeptide receptor 0.0074 0.0572 0.1227
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0482 0.1009
Brugia malayi nuclear hormone receptor 0.0026 0.0013 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0013 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) hypothetical protein 0.0197 0.1997 0.5928
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.0572 0.1203
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0572 0.1203
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0572 0.1697
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Schistosoma mansoni amine GPCR 0.0074 0.0572 0.1203
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0052 0.0316 0.0653
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.0572 0.1203
Schistosoma mansoni biogenic amine receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0482 0.1431
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0013 0.0224
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.0572 0.1714
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0572 0.1697
Brugia malayi G-protein coupled receptor 0.0074 0.0572 0.1227
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0038
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.02 0.2027 0.6179
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.0572 0.1714
Onchocerca volvulus 0.0074 0.0572 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0259 0.2713 0.5822
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Onchocerca volvulus 0.0074 0.0572 1
Onchocerca volvulus 0.0074 0.0572 1
Schistosoma mansoni adenoreceptor 0.0074 0.0572 0.1203
Echinococcus multilocularis CREB binding protein 0.0069 0.051 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0013 0.0028
Brugia malayi sulfakinin receptor protein 0.0074 0.0572 0.1227
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.0572 0.1714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus g protein coupled receptor 0.0074 0.0572 0.1203
Brugia malayi ecdysteroid receptor 0.0026 0.0013 0.0028
Onchocerca volvulus 0.0074 0.0572 1
Echinococcus granulosus somatostatin receptor 0.0074 0.0572 0.1203
Schistosoma mansoni N-myristoyltransferase 0.0198 0.2005 0.4287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0013 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0013 0.0028
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0572 0.1203
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0572 0.1203
Schistosoma mansoni hypothetical protein 0.0074 0.0572 0.1203
Echinococcus granulosus choline O acetyltransferase 0.0203 0.2072 0.443
Schistosoma mansoni amine GPCR 0.0074 0.0572 0.1203
Echinococcus multilocularis somatostatin receptor 0.0074 0.0572 0.1714
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0068 0.0502 0.1501
Echinococcus granulosus CREB binding protein 0.0427 0.466 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.0572 0.1227
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Onchocerca volvulus 0.0074 0.0572 1
Loa Loa (eye worm) PDE1B protein 0.02 0.2027 0.6019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Schistosoma mansoni choline o-acyltransferase 0.0052 0.0316 0.0653
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) N-myristoyltransferase 2 0.0198 0.2005 0.5954
Brugia malayi AKH receptor 0.0074 0.0572 0.1227
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0482 0.1009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0572 0.1203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0013 0.0038
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0572 0.1714
Loa Loa (eye worm) hypothetical protein 0.0166 0.1635 0.4854
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0198 0.2005 1
Brugia malayi RE15519p 0.0074 0.0572 0.1227
Brugia malayi acetyltransferase, GNAT family protein 0.0307 0.3273 0.7024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0013 0.0038
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0166 0.1635 0.7807
Trichomonas vaginalis bromodomain-containing protein, putative 0.0105 0.0933 0.4513
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0572 0.1714
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0068 0.0502 0.1101
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.0572 0.1697
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.0572 0.1203
Onchocerca volvulus 0.0074 0.0572 1
Echinococcus multilocularis CREB binding protein 0.0069 0.051 0.1524
Onchocerca volvulus 0.0074 0.0572 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0572 0.1203
Schistosoma mansoni biogenic amine receptor 0.0074 0.0572 0.1203
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0013 0.0028
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0166 0.1635 0.349
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.0572 0.1227
Trypanosoma brucei N-myristoyl transferase, putative 0.0198 0.2005 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0572 0.1203
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0068 0.0502 0.1101
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.0572 0.1714
Echinococcus multilocularis serotonin receptor 0.0074 0.0572 0.1714
Brugia malayi Serotonin receptor 0.0074 0.0572 0.1227
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.0572 0.1697
Trypanosoma cruzi N-myristoyl transferase, putative 0.0198 0.2005 1
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.0572 0.1714
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0166 0.1635 0.4975
Brugia malayi Dopamine receptor protein 1 0.0074 0.0572 0.1227
Onchocerca volvulus 0.0026 0.0013 0.0224
Echinococcus multilocularis sex peptide receptor 0.0074 0.0572 0.1714
Brugia malayi Dopamine receptor protein 2 0.0074 0.0572 0.1227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Echinococcus granulosus fmrfamide receptor 0.0074 0.0572 0.1203
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.0572 0.1203
Mycobacterium ulcerans naphthoate synthase 0.0887 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0482 0.1034
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0272 0.2864 0.8744
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0013 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0572 0.1203
Schistosoma mansoni hypothetical protein 0.0074 0.0572 0.1203
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Brugia malayi hypothetical protein 0.0074 0.0572 0.1227
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0572 0.1714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus g protein coupled receptor 0.0074 0.0572 0.1203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0572 0.1203
Onchocerca volvulus 0.0052 0.0316 0.5529
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.0572 0.1227
Echinococcus granulosus CREB binding protein 0.0266 0.2795 0.5986
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0482 0.1009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0383 0.0796
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.0572 0.1203
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.0572 0.1203
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.0572 0.1697
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0272 0.2864 0.6134
Schistosoma mansoni amine GPCR 0.0074 0.0572 0.1203
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0572 0.1203
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.0572 0.1203
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0013 0.0028
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.0572 0.1697
Loa Loa (eye worm) hypothetical protein 0.0074 0.0572 0.1697
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0572 0.1203
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0572 0.1203
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0105 0.0933 0.4513
Schistosoma mansoni biogenic amine receptor 0.0074 0.0572 0.1203
Giardia lamblia CDC72 0.0198 0.2005 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.0572 0.1203
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0052 0.0316 0.0939
Schistosoma mansoni neuropeptide receptor 0.0074 0.0572 0.1203
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0572 0.1714
Echinococcus granulosus sex peptide receptor 0.0074 0.0572 0.1203
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.0572 0.1227

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.000182 M Inhibition of pig kidney aldose reductase (ALR2) ChEMBL. 14667216
IC50 (binding) = 0.000182 M Inhibition of pig kidney aldose reductase (ALR2) ChEMBL. 14667216
IC50 (functional) > 500 uM Cytotoxicity against mouse L1210 cells ChEMBL. 20149656
IC50 (functional) > 500 uM Cytotoxicity against human CEM cells ChEMBL. 20149656

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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