Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0043 | 0.1056 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0265 | 0.2242 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0043 | 0.1056 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0265 | 0.2242 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0043 | 0.1056 | 0.5 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0043 | 0.1056 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0043 | 0.1056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1056 | 0.1023 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0265 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1056 | 0.1023 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0043 | 0.1056 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0037 | 0.0349 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.021 | 0.7625 | 0.7616 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.027 | 1 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0043 | 0.1056 | 0.1023 |
Brugia malayi | protein ZK524.3 | 0.0043 | 0.1056 | 0.0812 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0265 | 0.2513 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0265 | 0.2242 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0043 | 0.1056 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0043 | 0.1056 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0265 | 0.2242 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.021 | 0.7625 | 0.7616 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0265 | 0.2242 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0043 | 0.1056 | 0.1023 |
Onchocerca volvulus | 0.0023 | 0.0265 | 0.5 | |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0043 | 0.1056 | 1 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.021 | 0.7625 | 0.7344 |
Treponema pallidum | methionyl-tRNA synthetase | 0.027 | 1 | 1 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.021 | 0.7625 | 0.7344 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0043 | 0.1056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0265 | 0.0229 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0265 | 0.2242 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.027 | 1 | 1 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0043 | 0.1056 | 1 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0043 | 0.1056 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0043 | 0.1056 | 0.5 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.027 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0265 | 0.2242 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0043 | 0.1056 | 1 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.021 | 0.7625 | 0.7344 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0043 | 0.1056 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0265 | 0.0229 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0043 | 0.1056 | 0.5 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0043 | 0.1056 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.027 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0265 | 0.2242 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.027 | 1 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0043 | 0.1056 | 0.0812 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0265 | 0.2513 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0043 | 0.1056 | 0.5 |
Brugia malayi | glycyl-tRNA synthetase | 0.021 | 0.7625 | 0.756 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1056 | 1 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.021 | 0.7625 | 0.756 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0227 | 0.8306 | 0.83 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0043 | 0.1056 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 8 % | Inhibition of Cytochrome P450 19A1 at the concentration of 0.25 uM | ChEMBL. | 3959033 |
Inhibition (binding) | = 8 % | Inhibition of Cytochrome P450 19A1 at the concentration of 0.25 uM | ChEMBL. | 3959033 |
Inhibition (binding) | = 12 % | Inhibition of Cytochrome P450 19A1 at the concentration of 0.75 uM | ChEMBL. | 3959033 |
Inhibition (binding) | = 12 % | Inhibition of Cytochrome P450 19A1 at the concentration of 0.75 uM | ChEMBL. | 3959033 |
Inhibition (binding) | = 18 % | Inhibition of Cytochrome P450 19A1 at the concentration of 1.5 uM | ChEMBL. | 3959033 |
Inhibition (binding) | = 18 % | Inhibition of Cytochrome P450 19A1 at the concentration of 1.5 uM | ChEMBL. | 3959033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.