Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein geranylgeranyltransferase type I, beta subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | protein farnesyltransferase beta subunit | protein geranylgeranyltransferase type I, beta subunit | 377 aa | 361 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.024 | 0.0632 | 1 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.024 | 0.0632 | 0.1067 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.024 | 0.0632 | 0.1067 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 0.0187 | 0.5 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.024 | 0.0632 | 0.0775 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 0.0187 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.2539 | 0.2539 |
Echinococcus granulosus | integrin alpha 3 | 0.0617 | 0.4159 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0247 | 0.0698 | 0.1679 |
Schistosoma mansoni | integrin alpha | 0.0804 | 0.5918 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0361 | 0.1759 | 0.4231 |
Echinococcus multilocularis | integrin alpha ps | 0.0361 | 0.1759 | 0.4231 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.024 | 0.0632 | 0.1519 |
Schistosoma mansoni | integrin beta subunit | 0.0197 | 0.0223 | 0.0377 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 0.0187 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.4298 | 0.4298 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.024 | 0.0632 | 0.1519 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 0.0187 | 0.0317 |
Echinococcus multilocularis | integrin alpha 3 | 0.0617 | 0.4159 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0361 | 0.1759 | 0.4231 |
Echinococcus granulosus | integrin beta 2 | 0.0247 | 0.0698 | 0.1679 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.014 |
Loa Loa (eye worm) | integrin beta-2 | 0.0334 | 0.151 | 0.151 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.0187 | 0.0187 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 0.0187 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0608 | 0.4082 | 0.4082 |
Schistosoma mansoni | integrin alpha-ps | 0.0188 | 0.014 | 0.0236 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0608 | 0.4082 | 0.6796 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0804 | 0.5918 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.024 | 0.0632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.024 | 0.0632 | 0.0632 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0334 | 0.151 | 0.2307 |
Schistosoma mansoni | integrin alpha-ps | 0.0361 | 0.1759 | 0.2973 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 0.0187 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38 nM | Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase. | ChEMBL. | 11392531 |
IC50 (binding) | = 38 nM | Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase. | ChEMBL. | 11392531 |
IC50 (binding) | = 920 nM | Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-transferase type I. | ChEMBL. | 11392531 |
IC50 (binding) | = 920 nM | Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-transferase type I. | ChEMBL. | 11392531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.