TDR Targets

Basic information

Technical information

TDR Targets ID: 272586
Name: N-[[6-[2-(diaminomethylideneamino)-1,3-thiazo l-4-yl]pyridin-2-yl]methyl]oxolane-2-carboxam ide
MW: 346.407 | Formula: C15H18N6O2S
H donors: 3 H acceptors: 3 LogP: 0.16 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)Nc1scc(n1)c1cccc(n1)CNC(=O)C1CCCO1
InChi: 1S/C15H18N6O2S/c16-14(17)21-15-20-11(8-24-15)10-4-1-3-9(19-10)7-18-13(22)12-5-2-6-23-12/h1,3-4,8,12H,2,5-7H2,(H,18,22)(H4,16,17,20,21)
InChiKey: HBKLVWVODJOEPK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[[6-(2-guanidinothiazol-4-yl)-2-pyridyl]methyl]tetrahydrofuran-2-carboxamide
N-[[6-(2-guanidino-4-thiazolyl)-2-pyridyl]methyl]-2-tetrahydrofurancarboxamide
N-[[6-[2-[bis(azanyl)methylideneamino]-1,3-thiazol-4-yl]pyridin-2-yl]methyl]oxolane-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0301	0.0476
Echinococcus granulosus	tubulin alpha chain	0.0046	0.0336	0.0531
Echinococcus granulosus	tubulin alpha chain	0.0046	0.0336	0.0531
Echinococcus multilocularis	RUN	0.0062	0.0699	0.1107
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Loa Loa (eye worm)	tubulin beta-1 chain	0.0045	0.0301	0.0301
Plasmodium vivax	tubulin alpha chain, putative	0.0046	0.0336	0.3311
Echinococcus multilocularis	tubulin subunit beta	0.0045	0.0301	0.0476
Schistosoma mansoni	rab6-interacting	0.0062	0.0699	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0039	0.0039
Loa Loa (eye worm)	alpha-tubulin	0.0046	0.0336	0.0336
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0034	0.0047	0.0074
Brugia malayi	hypothetical protein	0.0049	0.0392	0.0392
Echinococcus granulosus	beta tubulin	0.0045	0.0301	0.0476
Loa Loa (eye worm)	BEN-1 protein	0.0045	0.0301	0.0301
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0001	0.0002
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0336	0.0336
Brugia malayi	Tubulin beta-1 chain	0.0045	0.0301	0.0301
Schistosoma mansoni	lipoxygenase	0.0193	0.3734	0.5909
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1011	0.1011
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Loa Loa (eye worm)	tubulin alpha chain	0.0046	0.0336	0.0336
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0001	0.0001
Echinococcus granulosus	tubulin alpha chain	0.0046	0.0336	0.0531
Echinococcus multilocularis	beta tubulin	0.0045	0.0301	0.0476
Loa Loa (eye worm)	BEN-1 protein	0.0045	0.0301	0.0301
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0046	0.0336	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0045	0.0301	0.0301
Brugia malayi	hypothetical protein	0.0062	0.0699	0.0699
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0046	0.0336	0.0531
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0472
Echinococcus multilocularis	tubulin alpha chain	0.0046	0.0336	0.0531
Plasmodium vivax	tubulin alpha chain, putative	0.0046	0.0336	0.3311
Plasmodium vivax	tubulin beta chain, putative	0.0045	0.0301	0.297
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0034	0.0047	0.0074
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0298	0.0298
Plasmodium falciparum	alpha tubulin 1	0.0046	0.0336	0.3311
Echinococcus granulosus	tubulin subunit TubB	0.0046	0.0336	0.0531
Echinococcus granulosus	RUN	0.0062	0.0699	0.1107
Echinococcus multilocularis	tubulin beta 1 chain	0.0045	0.0301	0.0476
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0301	0.0476
Echinococcus multilocularis	tubulin subunit TubB	0.0046	0.0336	0.0531
Plasmodium vivax	multidomain scavenger receptor, putative	0.0062	0.0699	0.6914
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0045	0.0301	0.8837
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0298	0.0472
Echinococcus granulosus	beta tubulin	0.0045	0.0301	0.0476
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.063	0.063
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.1592	0.1592
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Echinococcus multilocularis	tubulin alpha chain	0.0046	0.0336	0.0531
Plasmodium falciparum	tubulin beta chain	0.0045	0.0301	0.297
Echinococcus granulosus	tubulin alpha 1C chain	0.0046	0.0336	0.0531
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Echinococcus multilocularis	tubulin alpha 3 chain	0.0046	0.0336	0.0531
Giardia lamblia	Alpha-tubulin	0.0046	0.0336	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0046	0.0336	0.0531
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.1592	0.1592
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0298	0.0472
Trichomonas vaginalis	tubulin beta chain, putative	0.0046	0.0336	1
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0301	0.0476
Echinococcus multilocularis	tubulin alpha 1C chain	0.0046	0.0336	0.0531
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Loa Loa (eye worm)	hypothetical protein	0.01	0.1592	0.1592
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0046	0.0336	0.0531
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0855	0.0855
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0045	0.0301	0.8837
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Brugia malayi	hypothetical protein	0.0062	0.0699	0.0699
Echinococcus granulosus	alpha tubulin	0.0046	0.0336	0.0531
Echinococcus granulosus	tubulin beta 1 chain	0.0045	0.0301	0.0476
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Echinococcus granulosus	Tubulin alpha 1 chain	0.0046	0.0336	0.0531
Toxoplasma gondii	beta tubulin	0.0045	0.0301	0.297
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0472
Toxoplasma gondii	alpha tubulin TUBA1	0.0046	0.0336	0.3311
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Schistosoma mansoni	hypothetical protein	0.0069	0.0855	0.1353
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0046	0.0336	1
Brugia malayi	beta-tubulin, identical	0.0045	0.0301	0.0301
Trichomonas vaginalis	tubulin beta chain, putative	0.0046	0.0336	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0046	0.0336	0.0531
Trypanosoma brucei	alpha tubulin	0.0046	0.0336	0.3311
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Schistosoma mansoni	rab6-interacting	0.0062	0.0699	0.1107
Trypanosoma brucei	beta tubulin	0.0045	0.0301	0.297
Schistosoma mansoni	tubulin subunit alpha	0.0046	0.0336	0.0531
Trypanosoma brucei	beta tubulin	0.0045	0.0301	0.297
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Echinococcus granulosus	geminin	0.0177	0.3366	0.5326
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0298	0.0298
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0298	0.0472
Brugia malayi	tubulin alpha chain - mouse	0.0046	0.0336	0.0336
Echinococcus granulosus	peroxisome assembly protein 26	0.0046	0.0336	0.0531
Schistosoma mansoni	loxhd1	0.0062	0.0699	0.1107
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Schistosoma mansoni	tubulin subunit alpha	0.0046	0.0336	0.0531
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.1592	0.1592
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0001	0.0002
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0301	0.0476
Trichomonas vaginalis	tubulin beta chain, putative	0.0046	0.0336	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0046	0.0336	0.3311
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0033	0.0039	0.0039
Toxoplasma gondii	beta-1 tubulin, putative	0.0045	0.0301	0.297
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Brugia malayi	Tubulin alpha-2 chain	0.0046	0.0336	0.0336
Schistosoma mansoni	alpha tubulin	0.0046	0.0336	0.0531
Trichomonas vaginalis	tubulin beta chain, putative	0.0045	0.0301	0.8837
Trypanosoma cruzi	beta tubulin, putative	0.0045	0.0301	0.297
Echinococcus granulosus	tubulin beta 4A class IVa	0.0045	0.0301	0.0476
Trichomonas vaginalis	tubulin alpha chain, putative	0.0045	0.0301	0.8837
Echinococcus granulosus	tubulin alpha chain	0.0046	0.0336	0.0531
Plasmodium falciparum	ataxin-2 like protein, putative	0.0075	0.1011	1
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0301	0.0476
Brugia malayi	Cytochrome P450 family protein	0.0059	0.063	0.063
Schistosoma mansoni	hypothetical protein	0.0034	0.0047	0.0074
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Plasmodium vivax	ataxin-2 like protein, putative	0.0075	0.1011	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0855	0.0855
Schistosoma mansoni	hypothetical protein	0.0177	0.3366	0.5326
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Trichomonas vaginalis	tubulin, putative	0.0045	0.0301	0.8837
Plasmodium falciparum	LCCL domain-containing protein	0.0062	0.0699	0.6914
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0046	0.0336	0.0336
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Entamoeba histolytica	tubulin alpha-1 chain	0.0046	0.0336	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0298	0.0472
Plasmodium falciparum	ataxin-2 like protein, putative	0.0075	0.1011	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0699	0.0699
Treponema pallidum	ATP-binding protein (ylxH-1)	0.0449	0.9689	0.5
Trypanosoma brucei	PAB1-binding protein , putative	0.0075	0.1011	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0062	0.0699	0.1107
Giardia lamblia	Alpha-tubulin	0.0046	0.0336	1
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Brugia malayi	Doublecortin family protein	0.0062	0.0699	0.0699
Trichomonas vaginalis	tubulin beta chain, putative	0.0046	0.0336	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0046	0.0336	0.0531
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0045	0.0301	0.0476
Loa Loa (eye worm)	alpha-tubulin	0.0046	0.0336	0.0336
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0001	0.0002
Echinococcus multilocularis	tubulin alpha chain	0.0046	0.0336	0.0531
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0472
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0046	0.0336	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0062	0.0699	0.1107
Schistosoma mansoni	lipoxygenase	0.0304	0.632	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0062	0.0699	0.1107
Toxoplasma gondii	LsmAD domain-containing protein	0.0075	0.1011	1
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Loa Loa (eye worm)	tubulin alpha 2	0.0033	0.0039	0.0039
Trichomonas vaginalis	tubulin beta chain, putative	0.0046	0.0336	1
Schistosoma mansoni	hypothetical protein	0.0177	0.3366	0.5326
Trypanosoma brucei	alpha tubulin	0.0046	0.0336	0.3311
Brugia malayi	alpha-tubulin	0.0046	0.0336	0.0336
Brugia malayi	Tubulin alpha-2 chain	0.0046	0.0336	0.0336
Echinococcus multilocularis	beta tubulin	0.0045	0.0301	0.0476
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Echinococcus multilocularis	peroxisome assembly protein 26	0.0046	0.0336	0.0531
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0304	0.632	1
Echinococcus multilocularis	geminin	0.0177	0.3366	0.5326
Onchocerca volvulus		0.0462	1	1
Schistosoma mansoni	hypothetical protein	0.0062	0.0699	0.1107
Schistosoma mansoni	alpha tubulin	0.0046	0.0336	0.0531
Brugia malayi	tubulin alpha-2 chain	0.0046	0.0336	0.0336
Trichomonas vaginalis	tubulin gamma chain, putative	0.0045	0.0301	0.8837
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0001	0.0001
Trypanosoma brucei	alpha tubulin	0.0046	0.0336	0.3311
Leishmania major	alpha tubulin	0.0046	0.0336	0.3311
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0001	0.0002
Trichomonas vaginalis	tubulin beta chain, putative	0.0046	0.0336	1
Schistosoma mansoni	alpha tubulin	0.0046	0.0336	0.0531
Echinococcus granulosus	tubulin alpha 1C chain	0.0046	0.0336	0.0531
Echinococcus granulosus	tubulin subunit beta	0.0045	0.0301	0.0476
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Echinococcus granulosus	tubulin alpha chain	0.0046	0.0336	0.0531
Echinococcus multilocularis	Polycystic kidney disease protein	0.0062	0.0699	0.1107
Loa Loa (eye worm)	tubulin alpha chain	0.0046	0.0336	0.0336
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Brugia malayi	Tubulin alpha chain	0.0046	0.0336	0.0336
Schistosoma mansoni	polycystin 1-related	0.0062	0.0699	0.1107
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0001	0.0001
Trypanosoma cruzi	alpha tubulin, putative	0.0046	0.0336	0.3311
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0032	0.0001	0.5
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0301	0.0476
Loa Loa (eye worm)	tubulin beta chain	0.0045	0.0301	0.0301
Loa Loa (eye worm)	doublecortin family protein	0.0062	0.0699	0.0699
Trypanosoma cruzi	PAB1-binding protein , putative	0.0075	0.1011	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0075	0.1011	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0062	0.0699	0.1107
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0001	0.0002
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0046	0.0336	0.0531
Trypanosoma brucei	beta tubulin	0.0045	0.0301	0.297
Loa Loa (eye worm)	hypothetical protein	0.0462	1	1
Echinococcus multilocularis	hypothetical protein	0.0046	0.0336	0.0531
Leishmania major	beta tubulin	0.0045	0.0301	0.297
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0699	0.0699
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0301	0.0476
Loa Loa (eye worm)	tubulin alpha 2	0.0033	0.0039	0.0039
Leishmania major	hypothetical protein, conserved	0.0075	0.1011	1
Schistosoma mansoni	tubulin subunit alpha	0.0046	0.0336	0.0531
Brugia malayi	hypothetical protein	0.0075	0.1011	0.1011
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0062	0.0699	0.1107
Echinococcus multilocularis	tubulin alpha 1C chain	0.0046	0.0336	0.0531
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0001	0.0002
Echinococcus multilocularis	tubulin alpha chain	0.0046	0.0336	0.0531
Echinococcus multilocularis	tubulin alpha 3 chain	0.0046	0.0336	0.0531
Echinococcus granulosus	tubulin alpha 3 chain	0.0046	0.0336	0.0531
Loa Loa (eye worm)	tubulin beta-2A chain	0.0045	0.0301	0.0301
Echinococcus multilocularis	tubulin alpha chain	0.0046	0.0336	0.0531
Trypanosoma brucei	alpha tubulin	0.0046	0.0336	0.3311
Toxoplasma gondii	beta-tubulin, putative	0.0045	0.0301	0.297
Loa Loa (eye worm)	beta-tubulin	0.0045	0.0301	0.0301
Trypanosoma brucei	beta tubulin	0.0045	0.0301	0.297
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0304	0.632	1
Plasmodium falciparum	alpha tubulin 2	0.0046	0.0336	0.3311
Entamoeba histolytica	tubulin alpha chain, putative	0.0046	0.0336	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 6 %	Inhibition of histamine stimulated gastric acid secretion in lumen perfused anaesthetized rats after 1 mg/kg intravenous dose	ChEMBL.	7904648
Inhibition (functional)	= 7 %	H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium at 1x10E-6 g/mL.	ChEMBL.	7904648
Inhibition (functional)	= 7 %	H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium at 1x10E-6 g/mL.	ChEMBL.	7904648
Inhibition (functional)	< 66 %	Inhibition of aspirin induced gastric lesions in rats after peroral dose of 32 mg/kg	ChEMBL.	7904648

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL346550
PubChem: 10360256

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 272586