Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Squalene synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.3861 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.3061 | 0.7389 | 0.7389 |
Entamoeba histolytica | hypothetical protein | 0.0799 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0799 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0799 | 0 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0799 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3061 | 0.7389 | 0.7389 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3061 | 0.7389 | 0.7389 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.3861 | 1 | 1 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0799 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0799 | 0 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.3861 | 1 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0799 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3061 | 0.7389 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Treponema pallidum | pfs protein (pfs) | 0.0799 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0799 | 0 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.3861 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0799 | 0 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0799 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.3861 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0799 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0799 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Chlamydia trachomatis | AMP nucleosidase | 0.0799 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0799 | 0 | 0.5 |
Trypanosoma brucei | uridine phosphorylase | 0.0799 | 0 | 0.5 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0799 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.3861 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | NA 0 mg kg-1 | In vivo oral effective dose of the compound against cholesterol biosynthesis in rats; Inactive at 20 mg/Kg | ChEMBL. | 8576905 |
ED50 (functional) | = 0.42 mg kg-1 | In vivo intravenous effective dose of the compound against cholesterol biosynthesis in rats | ChEMBL. | 8576905 |
IC50 (binding) | = 76 nM | Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]-FPP as radioligand | ChEMBL. | 8576905 |
IC50 (binding) | = 76 nM | Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]-FPP as radioligand | ChEMBL. | 8576905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.