Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Trypanosoma brucei | uridine phosphorylase | 0.0493 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.2382 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0493 | 0 | 0.5 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0493 | 0 | 0.5 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.2382 | 1 | 1 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.1353 | 0.1831 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0493 | 0 | 0.5 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0493 | 0 | 0.5 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0493 | 0 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.2382 | 1 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.2382 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1888 | 0.7389 | 0.7389 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.2382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1888 | 0.7389 | 1 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.1353 | 0.1353 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0493 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0493 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0493 | 0 | 0.5 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0493 | 0 | 0.5 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0493 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1888 | 0.7389 | 0.7389 |
Treponema pallidum | pfs protein (pfs) | 0.0493 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0493 | 0 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0493 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0493 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.0493 | 0 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.1888 | 0.7389 | 0.7389 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0493 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.2382 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.11 uM | In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 | ChEMBL. | 2981324 |
IC50 (binding) | = 0.11 uM | In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 | ChEMBL. | 2981324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.