Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0404 | 0.2348 | 0.2348 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1267 | 0.7674 | 1 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.002 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.1645 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.002 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1567 | 0.195 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.0141 | 0.007 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 0.5043 | 0.5043 |
Brugia malayi | RNA binding protein | 0.0126 | 0.0634 | 0.0634 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1211 | 0.7324 | 0.7324 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.0858 | 0.1014 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0141 | 0.0141 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.0141 | 0.007 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0141 | 0.0141 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1645 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0404 | 0.2348 | 0.2348 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Schistosoma mansoni | tyrosinase precursor | 0.0404 | 0.2348 | 0.2979 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1211 | 0.7324 | 0.7324 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1645 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1645 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.0141 | 0.007 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.018 | 0.0121 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Onchocerca volvulus | 0.0046 | 0.0141 | 0.0193 | |
Brugia malayi | hypothetical protein | 0.0026 | 0.002 | 0.002 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.0634 | 0.0634 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.018 | 0.018 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0179 | 0.0967 | 0.1158 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0404 | 0.2348 | 0.2348 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.0858 | 0.1014 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1211 | 0.7324 | 0.9539 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0833 | 0.4995 | 0.6469 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.0634 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.2348 | 0.2348 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0162 | 0.0858 | 0.1014 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.0141 | 0.007 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.018 | 0.0121 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0404 | 0.2348 | 0.2348 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.0634 | 0.072 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.0634 | 0.0634 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0141 | 0.007 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.0634 | 0.0634 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1267 | 0.7674 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0088 | 0.0088 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.0141 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0404 | 0.2348 | 0.2348 |
Brugia malayi | ShTK domain containing protein | 0.0404 | 0.2348 | 0.2348 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.0141 | 0.007 |
Schistosoma mansoni | tyrosinase precursor | 0.0404 | 0.2348 | 0.2979 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1211 | 0.7324 | 0.9539 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0404 | 0.2348 | 0.2348 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0404 | 0.2348 | 0.2348 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1211 | 0.7324 | 0.9539 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.0141 | 0.0141 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.018 | 0.0121 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1267 | 0.7674 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0404 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.0634 | 0.0634 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.0634 | 0.0634 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0141 | 0.007 |
Echinococcus granulosus | geminin | 0.0162 | 0.0858 | 0.1014 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.002 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.002 | 0.002 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.018 | 0.018 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1211 | 0.7324 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0179 | 0.0967 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0141 | 0.0141 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.018 | 0.0121 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.018 | 0.0121 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.74 | Susceptibility to hog kidney dehydropeptidase-I. | ChEMBL. | 10201828 |
MIC (functional) | = 0.062 ug ml-1 | Antibacterial activity of the compound against Methicillin sensitive Staphylococcus aureus-/+ HSA Fr. V | ChEMBL. | 10201828 |
MIC (functional) | = 0.062 ug ml-1 | Effect of 43 mg/mL of Human Serum Albumin, Fraction V (HSA Fr. V) on antimicrobial activity was assessed against MSSA strain MB 2985 | ChEMBL. | 10201828 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity against PRSP. | ChEMBL. | 10201828 |
MIC (functional) | = 8 ug ml-1 | In vitro antibacterial activity against MRSA. | ChEMBL. | 10201828 |
MIC (functional) | = 12.1 ug ml-1 | In vitro antibacterial activity against MRCNS. | ChEMBL. | 10201828 |
MIC (functional) | = 16 ug ml-1 | In vitro antibacterial activity against MDREFm. | ChEMBL. | 10201828 |
MIC (functional) | = 32 ug ml-1 | In vitro antibacterial activity against VREFs. | ChEMBL. | 10201828 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.