Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0219 | 0.1103 | 0.1103 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0205 | 0.0894 | 0.0894 |
Schistosoma mansoni | hypothetical protein | 0.0219 | 0.1103 | 0.1103 |
Toxoplasma gondii | peptidase family M13 protein | 0.0841 | 1 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0841 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0621 | 0.6858 | 0.655 |
Echinococcus multilocularis | aminopeptidase N | 0.0377 | 0.3359 | 0.3359 |
Loa Loa (eye worm) | hypothetical protein | 0.0621 | 0.6858 | 0.655 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0841 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.7067 | 0.678 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0424 | 0.4036 | 0.4036 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0205 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.3925 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.7067 | 0.678 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0424 | 0.4036 | 0.4036 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0492 | 0.4999 | 0.4999 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0205 | 0.0894 | 0.0894 |
Onchocerca volvulus | 0.0417 | 0.3925 | 1 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0424 | 0.4036 | 0.4036 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0621 | 0.6858 | 0.655 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0424 | 0.4036 | 0.4036 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0205 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.249 | 0.1753 |
Schistosoma mansoni | hypothetical protein | 0.0219 | 0.1103 | 0.1103 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0618 | 0.681 | 0.6497 |
Schistosoma mansoni | hypothetical protein | 0.0219 | 0.1103 | 0.1103 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0424 | 0.4036 | 0.4036 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0841 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0205 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0621 | 0.6858 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 1 | 1 |
Schistosoma mansoni | neprilysin | 0.0219 | 0.1103 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.7067 | 0.678 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0618 | 0.681 | 0.6497 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0841 | 1 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0492 | 0.4999 | 0.4999 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 1 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0841 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0219 | 0.1103 | 0.1103 |
Brugia malayi | Peptidase family M1 containing protein | 0.0377 | 0.3359 | 0.2707 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0492 | 0.4999 | 0.4509 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1526 | 0.0694 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0492 | 0.4999 | 0.4999 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.031 | 0.2395 | 0.1649 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.7067 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.7067 | 0.678 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0205 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0621 | 0.6858 | 0.655 |
Schistosoma mansoni | hypothetical protein | 0.0219 | 0.1103 | 0.1103 |
Echinococcus granulosus | aminopeptidase N | 0.0377 | 0.3359 | 0.3359 |
Brugia malayi | hypothetical protein | 0.0209 | 0.0956 | 0.0069 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0219 | 0.1103 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0621 | 0.6858 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0841 | 1 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0841 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.7067 | 0.678 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I (functional) | = 15 % | Percent inhibition was determined for in vivo ionophore induced rat pleurisy at a dose of 3 mg/kg | ChEMBL. | 10691695 |
IC50 (functional) | = 20 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
IC50 (functional) | = 20 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.